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Journals / Bakırköy Tıp Dergisi / 2009 / Cilt: 5 - Sayı: 3

Heat shock proteins (HSP) and progesterone (pr) receptors in ovarian cancer

Over kanserinde sıcak şok proteinleri (HSP) ve progesteron reseptörleri (PR)

SİBEL AKYOL
Pages
83–91
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The same HSP can, according to cancer type, lead to positive or negative prognoses.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Heat shock proteins (HSP), are structures thought to have functions similar to those of strong cytokines, which govern interactions between proteins, maintain balance in these interactions and modify their structure.
📊
Key Findings & Data:HSP’s identify immune system disease cells intracellularly by developing memory storages and red flags and extracellularly by sending danger signals.
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Conclusion & Impact:The same HSP can, according to cancer type, lead to positive or negative prognoses.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Progesteron · Isı-şok proteinleri · İmmün baskılama

Abstract

Heat shock proteins (HSP), are structures thought to have functions similar to those of strong cytokines, which govern interactions between proteins, maintain balance in these interactions and modify their structure. HSP’s identify immune system disease cells intracellularly by developing memory storages and red flags and extracellularly by sending danger signals. HSP’s are classified into two groups according to molecular weight. The small HSP’s, denoted as HSP 27, 60, 70 and 90 have been found to bind to various types of malignant tumors. Interactions with HSP activation factor (AF) have been found to cause steroid hormone receptors i.e. progesterone receptors (PR) to form complexes with HSP’s especially those containing HSP90. Any breakdown in the relationship between progesterone receptors (PR) and HSP, by impairing gene activation affects the formation of malignant growths. The role of HSP’s in cancer is still a mystery. The same HSP can, according to cancer type, lead to positive or negative prognoses.

Özet

Sıcak şok proteinleri (Heat Shock Protein, HSP), proteinlerin birbiriyle etkileşimini sağlayan, iç etkileşimde denge rolü oynayan, protein yapılarını modifiye eden, güçlü sitokin benzeri fonksiyonları olduğu düşünülen yapılardır. İmmun sistemin hastalıklı hücreleri tanıyabilmesi için, HSP’le intraselüler (hafıza depoları ve red flag hücreleri oluşturarak) ve ekstraselüler (danger signal vererek) immun cevaplar oluştururlar. HSP’ler molekül ağırlıklarına göre gruplara ayrılırlar. Küçük HSP’ler olarak adlandırılan HSP 27,60, 70 ve 90 ile malign tümörlerin değişik tipleri arasında bağlantılar gösterilmiştir. HSP’nin aktivasyon faktörleri (AF) ile etkileşiminde, steroid hormon reseptörleri (progesteron reseptörü, PR) özellikle HSP90 içeren, HSP’lerle kompleks oluştururlar. Progesteron reseptörleri (PR) ile HSP fonksiyonları arasındaki ilişkinin bozulması, gen aktivasyonunu bozarak malign yapıların oluşumuna etki eder. Kanserde HSP ler hala sır niteliğindedir. Kanser çeşidine göre aynı HSP’nin etkisi kötü prognoz veya iyi prognoz şeklinde gelişmektedir. HSP tayini, kanserin teşhisi, tedavisi ve önlenmesinde büyük fayda sağlayacaktır.

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Cite This Article

AKYOL, S. (2009). Heat shock proteins (HSP) and progesterone (pr) receptors in ovarian cancer. Bakırköy Tıp Dergisi, Cilt: 5 - Sayı: 3, 83–91. https://ajindex.com/articles/132918

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