Journals / Bakırköy Tıp Dergisi / 2006 / Cilt: 2 - Sayı: 4

Determination of symptoms related to gastroosephageal reflux in patients with obesity and investigation of antireflux treatment

Obezite tanısı konulan hastalarda gastroözofageal reflü hastalığı semptomlarının belirlenmesi ve antireflü tedavinin irdelenmesi

Pages
130–133
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It was concluded that obese persons who lost weight exhibited fewer symptoms.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of the study was to determine the correlation between body mass index and reflux symptoms, and also to investigate the effect of obesity on gastroesophageal reflux disease and its treatment.
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Key Findings & Data:Material and Methods: Group 1 was comprised of 19 patients (9 female) of normal weight and having a body mass index of 24 kg/m2.
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Conclusion & Impact:It was concluded that obese persons who lost weight exhibited fewer symptoms.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Vücut kitle indeksi · Obezite · Gastroözefageal reflü

Abstract

Objective: The aim of the study was to determine the correlation between body mass index and reflux symptoms, and also to investigate the effect of obesity on gastroesophageal reflux disease and its treatment. Material and Methods: Group 1 was comprised of 19 patients (9 female) of normal weight and having a body mass index of 24 kg/m2. Group 2 was comprised of 32 preobese patients (26 female) having a body mass index of 24-30 kg/m2 and Group 3 was comprised of 23 obese patients (12 female) having a body mass index of 30 kg/m2. Those who were observed as having gastroesephageal reflux symptoms were treated with a combination of proton pump inhibitors, motility regulators and H2 receptor blocking drugs for one month. Results: In the investigation it was understood that in the case of an increase in body mass index, cough and regurgitation problems increase (r=0.102, p0.01 and r=0.114, p0.01, respectively). Incidence of gastroesephageal reflux in Group 3 (91%) was significantly higher than in Group 1 (42%, r=0.114, p0.01), and though not significant still higher in Group 2 (69%, r=0.248, p0.06). The successful treatment of patients in Group 1 was significantly higher than in comparison with the other two groups. In comparison with other patients, within one month period a significant reduction was observed in symptoms of 6 patients (4 patients in Group 2 and 3 patients in Group 3) who lost 3-5 kg. Conclusion: Prevalence of gastroesefageal reflux disease was found to be higher in obese persons and the incidence and severity of symptoms was found to increase depending on body mass index. It was concluded that obese persons who lost weight exhibited fewer symptoms.

Özet

Amaç: Çalışmamızda vücut kitle oranı ile reflü semptomlarının ilişkisinin belirlenmesi, obezitenin bu hastalığa ve antireflü tedaviye etkisinin irdelenmesi amaçlandı. Gereç ve Yöntem: Grup 1’de vücut kitle oranı 24 kg/m2 olan normal kilolu toplam 19 (9’u kadın) hasta, Grup 2’de vücut kitle oranı 24-30 kg/m2 olan preobez toplam 32 (26’sı kadın) ve Grup 3’de ise vücut kitle oranı 30 kg/m2 olan toplam 23 (12’si kadın) obezite tanılı hasta çalışmaya alındı. Gastroözofageal reflü hastalığı kriterlerine uyanlara 1 aylık proton pompa inhibitörü, motilite düzenleyici ilaçlar ve H2 reseptör blokeri ilaçlar kombine olarak başlandı. Bulgular: Yapılan sorgulamada vücut kitle oranı arttıkça regürjitasyon ve kuru öksürük yakınmalarının anlamlı olarak arttığı (sırasıyla, r=0.102, p0.01 ve r=0.114, p0.01) tespit edildi. Grup 3 hastalarda gastroözofageal reşü hastalığı sıklığının (%91) Grup 1 hastalardan anlamlı olarak fazla olduğu (%42, r=0.114, p0.01), Grup 2 hastalarda ise anlamlı olmasa da fazla olduğu (%69, r=0.248, p0.06) saptandı. Tedavinin sonunda Grup 1 hastalarda tedavi başarısının diğer gruplardan anlamlı olarak fazla olduğu saptandı. Bir aylık süre içerisinde ortalama 3-5 kg kaybeden 6 hastanın ( Grup 2’de 4, Grup 3’de 2) diğer hastalara oranla semptomlarında anlamlı olarak azalma olduğu gözlendi. Sonuç: Gastroözofageal reflü hastalığının obez hastalarda sıklığının yüksek olduğu ve vücut kitle oranı ile semptomların sıklığı ve şiddetinde artma olduğu saptandı. Obez hastalarda kilo vermenin semptomlarda azalma yapacağı kanısına varıldı.

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Cite This Article

TANRIVERDİ, Ö. (2006). Determination of symptoms related to gastroosephageal reflux in patients with obesity and investigation of antireflux treatment. Bakırköy Tıp Dergisi, Cilt: 2 - Sayı: 4, 130–133. https://ajindex.com/articles/131709

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References (13)

  1. Ronkainen J, Aro P, Storskrubb T et all. High prevalence of gastroesophageal reflux symptoms and esophagitis with or without symptoms in the general adult Swedish population: a Kalixanda study report. Scand J Gastroenterol 2005; 40: 275- 285
  2. Baehr PH, McDonald GB. Esophageal infections: risk factors, presentations, diagnosis and treatment. Gastroenterol 1994; 106: 509-532. 3. de Oliveira SS, dos Santos Ida S, da Silva JF, Machado EC. Gastrooesophageal reflux disease: prevalence and associated factors. Arq Gastroenterol 2005; 42: 116-121 4. Barak N, Ehrenpreis ED, Harrison JR, Sitrin MD. Gastrooesophageal reflux disease in obesity: pathopyhsiological and therapeutic considerations. Obes Rev 2002; 3: 9-15
  3. Fisher BL, Pennathur A, Mutnick JL, Little AG. Obesity correlates with gastroesophageal reflux. Dig Dis Sci 1999; 44: 2290-2294
  4. Halsted CH. Obesity: effects on the liver and gastrointestinal system. Curr Opin Clin Nutr Metab Care 1999; 2: 425-429
  5. Hampel H, Abraham NS, El-Serag HB. Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications. Ann Intern Med 2005; 143: 199- 211
  6. Nilsson M, Lagergren J. The relation between body mass and gastro-oesophageal reflux. Best Pract Res Clin Gastroenterol 2004; 18: 1117-1123
  7. Csendes A, Burdiles P, Rojas J, Burgos A, Henriquez A. Pathological gastroesophageal reflux in patients with severe, morbid and hyperobesity. Rev Med Chil 2001; 129: 1038-1043
  8. Pellegrini M, Marzocca G. Reflux-like dyspepsia in obese patients. Recenti Prog Med 2002; 93: 681
  9. Lagergren J, Bergstrom R, Nyren O. No relation between body mass and gastro-oesophageal reflux symptoms in a Swedish population based study. Gut 2000; 47: 26- 29
  10. Kjellin A, Ramel S, Rossner S, Thor K. Gastroesophageal reflux in obese patients is not reduced by weight reduction. Scand J Gastroenterol 1996; 31: 1047- 1051
  11. Korn O, Puentes J, Sagastume H, Burdiles P, Csendes A. Gastroesophageal reflux and obesity. Rev Med Chil 1997; 125: 671-675
  12. Fraser-Moodie CA, Norton B, Gornall C, Magnago S, Weale AR, Holmes GK. Weight loss has an independent beneficial effect on symptoms of gastro-oesophageal reflux in patients who are overweight. Scand J Gastroenterol 1999; 34: 337-340
  13. Mathus-Vliegen EM, Tygat GN. Gastro-oesophageal reflux in obese subjects: influence of overweight, weight loss and chronic gastric balloon distension. Scand J Gastroenterol 2002; 37: 1246- 1252.