Journals / Bakırköy Tıp Dergisi / 2007 / Cilt: 3 - Sayı: 3

Ebstein-Barr virus as a rare cause of acute hepatitis: Case report

Akut hepatitin nadir sebeplerinden biri Epstein barr virus: Olgu sunumu

Pages
115–117
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We report here 25 years old patient with fever, sore throat, and 12-15 fold elevation in liver function tests and EBV was determined as the cause of viral hepatitis.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Most common cause of acute hepatitis are viral agents.
📊
Key Findings & Data:Hepatotropic virus constitute more than 95% of this group.
💡
Conclusion & Impact:We report here 25 years old patient with fever, sore throat, and 12-15 fold elevation in liver function tests and EBV was determined as the cause of viral hepatitis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Akut hastalık · Erişkin · Herpesvirüs 4

Abstract

Most common cause of acute hepatitis are viral agents. Hepatotropic virus constitute more than 95% of this group. A rare cause of acute hepatitis is Epstein Barr virus (EBV). The main disease caused by EBV is Infectious mononucleosis characterized by sore throat, fever, and adenopathy triad. Gastrointestinal manifestations are frequently present (80%), but often unrecognized. These manifestations include mild elevation (3-5 fold) in liver function tests in 5-10% cases, abdominal pain, and hepatosplenomegaly. However, little number of cases with serious hepatitis, fulminant liver failure, and splenic rupture related with EBV were also reported. We report here 25 years old patient with fever, sore throat, and 12-15 fold elevation in liver function tests and EBV was determined as the cause of viral hepatitis.

Özet

Akut hepatitlerin büyük kısmından viral etkenler sorumludur. Viral nedenlerin de %95’inden fazlasını hepatotrop virüsler oluşturur. Epstein Barr virus (EBV) akut hepatitin nadir sebeplerinden biridir ve sıklıkla ateş, boğaz ağrısı, adenopati triadı ile karakterize Enfeksiyoz mononükleoz (EM) nedenidir. Gastrointestinal sistem anifestasyonları sık olup (>%80) çoğu fark edilmez, %5-10 oranında orta derecede transaminaz (3-5 kat) yüksekliği, karın ağrısı, hepatosplenomegali olabilir. Ancak az sayıda EBV’ye bağlı ciddi hepatit, fulminan karaciğer yetersizliği ve dalak rüptürü vakaları bildirilmiştir. Bu yazıda ateş, boğaz ağrısı şikayetiyle başvuran, karaciğer enzimlerinde 12-15 kat yükseklik bulunan ve akut hepatit nedeni olarak nadir sebeplerden EBV saptanan 25 yaşındaki olguyu tartıştık.

🔖

Cite This Article

KARAMAN, Ö., USLAN, İ., ÇÖLBAY, M., ACARTÜRK, G., YÜKSEL, Ş., DANALIOĞLU, A. (2007). Ebstein-Barr virus as a rare cause of acute hepatitis: Case report. Bakırköy Tıp Dergisi, Cilt: 3 - Sayı: 3, 115–117. https://ajindex.com/articles/131597

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (19)

  1. Markin RS. Manifestations of Epstein-Barr virus-associated disorders in liver. Liver. 1994;14:1-13
  2. Cohen JI. Epstein-Barr virus infection. N Engl J Med 2000; 343: 481-492
  3. Macsween KF, Crawford DH. Epstein–Barr virus-recent advances. Lancet Infect Dis 2003; 3: 131–140
  4. Shaw NJ, Evans JH. Liver failure and Epstein-Barr virus infection. Arch Dis Child 1988; 63: 432-433
  5. Jenson HB. Epstein-Barr virus. In: Behrman RE, Kliegman RM, Jenson HB (Eds). Nelson’s Textbook of Pediatrics (16th ed). Philadelphia: WB Saunders, 2000: s. 977-981
  6. White NJ, Juel-Jensen BE. Infectious mononucleosis hepatitis. Semin Liver Dis 1984; 4: 301–306
  7. Tsuchiya S. Diagnosis of Epstein–Barr virus-associated diseases. Crit Rev Oncol Hematol 2002; 44: 227–238
  8. Wang DM, Zheng PJ. Severe hepatitis associated with Epstein–Barr virus in childhood. Chin Med J (England) 1988; 101: 454-455
  9. Hinedi TB, Koff RS. Cholestatic hepatitis induced by Epstein–Barr virus infection in an adult. Dig Dis Sci 2003; 48: 539-541
  10. Kimura H, Nagasaka T, Hoshino Y, et al. Severe hepatitis caused by Epstein–Barr virus without infection of hepatocytes. Hum Pathol 2001; 32: 757–762
  11. Arslan N, Akman H, Sayan M, Öztürk Y, Büyükgebiz B. Epstein-Barr virus enfeksiyonuna ikincil gelişen hepatik yetmezlik: Bir vaka takdimi. Çocuk Sağlığı ve Hastalıkları Dergisi 2003; 46: 47-49
  12. Epstein MA, Achong BG, Barr YM. Virus particles in cultured lymphoblasts from Burkitt’s lymphoma. Lancet 1964; 15: 702-703
  13. Henle G, Henle W, Diehl V. Relation of Burkitt’s tumor-associated herpes-type virus to infectious mononucleosis. Proc Natl Acad Sci U S A 1968; 59: 94-101
  14. Lehane DE. A seroepidemiologic study of infectious mononucleosis: the development of EB virus antibody in a military population. JAMA 1970; 212: 2240-2242
  15. Johannsen EC, Schooley RT, Kaye KM. Epstein-Barr virus (infectious mononucleosis). In: Mandell GM, Bennett JE, Dolin R (Eds). Principles and Practices of Infectious Diseases. 6th ed. Philadelphia, Churchill-Livingstone, 2005, p. 1801–1820
  16. Mason WR Jr, Adams EK. Infectious mononucleosis: an analysis of 100 cases with particular attention to diagnosis, liver function tests, and treatment of selected cases with prednisone. Am J Med Sci 1958; 236: 447-459
  17. Hoagland RJ. Infectious mononucleosis. Am J Med 1952; 13:158-171
  18. Finkel M, Parker GW, Fanselau HA. The hepatitis of infectious mononucleosis: experience with 235 cases. Mil Med 1964; 129: 533-538
  19. Hinedi