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Journals / Online Türk Sağlık Bilimleri Dergisi / 2024 / Cilt: 9 Sayı: 3

Diagnostic Value of Neutrophil/Lymphocyte Ratio in Distinguishing Peripheral and Central Vertigo in Patients with Dizziness

Baş Dönmesi Olan Hastalarda Periferik ve Santral Vertigonun Ayırt Edilmesinde Nötrofil/Lenfosit Oranının Tanısal Değeri

İskender Sertbaş(Trabzon Fatih Devlet Hastanesi)0000-0001-9948-3716
Mustafa Çiçek(Sağlık Bilimleri Üniversitesi Trabzon Kanuni Eğitim ve Araştırma Hastanesi)0000-0003-4307-3261
Metin Yadigaroğlu(SAMSUN UNIVERSITY)0000-0003-1771-5523
Sinan Paslı(KARADENIZ TECHNICAL UNIVERSITY)0000-0003-0052-2258
Selman Yeniocak(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL HASEKİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, ACİL TIP ANABİLİM DALI)0000-0002-1124-396X
Abdulkadir Gündüz(KARADENİZ TEKNİK ÜNİVERSİTESİ)0000-0001-8591-9769
Pages
240–245
Publication Date
2024-09-16
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Higher NLR values suggest central vertigo.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Neutrophil/lymphocyte ratio (NLR) is an inexpensive parameter that gives an idea about systemic inflammatory response and cellular immune response.
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Key Findings & Data:Materials and Methods: Patients presenting with acute vertigo at the emergency clinic were included between January 2017 and December 2018.
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Conclusion & Impact:Higher NLR values suggest central vertigo.
🔬Design:Review & Systematic Survey
📍Scope:2017 Verileri
⚙️Variables:Acil servis · ayırıcı tanı · baş dönmesi

Abstract

Objective: Neutrophil/lymphocyte ratio (NLR) is an inexpensive parameter that gives an idea about systemic inflammatory response and cellular immune response. This study aims to investigate the value of NLR in distinguishing peripheral and central vertigo. Materials and Methods: Patients presenting with acute vertigo at the emergency clinic were included between January 2017 and December 2018. Hemogram, brain computerized tomography, and diffusion magnetic resonance imaging data were reviewed to categorize patients into peripheral and central vertigo groups. Laboratory parameters were compared between these groups. Results: Neutrophil, lymphocyte, and C-reactive protein levels were higher in patients with central vertigo than those with peripheral vertigo (p=0.003, p=0.003, p=0.022, respectively). Moreover, the NLR value was significantly elevated in central vertigo cases (median: 3.99) in contrast to peripheral vertigo cases (median: 2.32) (p <0.001). Conclusions: The NLR is a valuable marker for distinguishing peripheral and central vertigo in emergency department patients with dizziness. Higher NLR values suggest central vertigo.

Özet

Amaç: Nötrofil/lenfosit oranı (NLR), sistemik inflamatuar yanıt ve hücresel bağışıklık yanıtı hakkında fikir veren düşük maliyetli bir parametredir. Bu çalışmanın amacı, NLR'nin periferik ve merkezi vertigo arasındaki farkı ayırt etmedeki değerini araştırmaktır. Materyal ve Metot: Ocak 2017 ile Aralık 2018 tarihleri arasında acil klinikte akut vertigo ile başvuran hastalar çalışmaya dahil edildi. Hastaları periferik ve merkezi vertigo gruplarına ayırmak için hemogram, beyin bilgisayarlı tomografi ve difüzyon manyetik rezonans görüntüleme verileri incelendi. Laboratuvar parametreleri bu gruplar arasında karşılaştırıldı. Bulgular: Nötrofil, lenfosit ve C-reaktif protein düzeyleri, periferik vertigo hastalarına kıyasla merkezi vertigo hastalarında daha yüksek bulundu (sırasıyla p=0,03, p=0,003, p=0,022). Ayrıca, NLR değeri merkezi vertigo vakalarında (ortalama: 3,99), periferik vertigo vakalarına kıyasla (ortalama: 2,32) anlamlı derecede yüksekti (p <0,001). Sonuç: NLR, vertigo semptomlarıyla acil servise başvuran hastalarda periferik ve merkezi vertigo arasındaki farkı ayırt etmede değerli bir belirleyicidir. Yüksek NLR değerleri merkezi vertigoyu düşündürmektedir.

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Cite This Article

Sertbaş, İ., Çiçek, M., Yadigaroğlu, M., Paslı, S., Yeniocak, S., Gündüz, A., *, M. Y. (2024). Diagnostic Value of Neutrophil/Lymphocyte Ratio in Distinguishing Peripheral and Central Vertigo in Patients with Dizziness. Online Türk Sağlık Bilimleri Dergisi, Cilt: 9 Sayı: 3, 240–245. https://doi.org/10.26453/otjhs.1461279

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References (27)

  1. Bayındır T, Kalcıoğlu MT. Peripheral vertigo. Journal of Turgut Ozal Medical Center. 2010;17:155-163.
  2. Fu Y, Liu Q, Anrather J, Shi FD. Immune interventions in stroke. Nat Rev Neurol 2015;11:524-535.
  3. Delémont C, Rutschmann O. Vertiges: tout tourne-t-il autour de la clinique? [Vertigo: it all revolves around the physical exam]. Rev Med Suisse. 2007;3(121):1826-1828.
  4. Tamhane UU, Aneja S, Montgomery D, Rogers EK, Eagle KA, Gurm HS. Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol. 2008;102:653-657.
  5. Talley NJ. Therapeutic options in nonulcer dyspepsia. J Clin Gastroenterol. 2001;32:286–293.
  6. Fu Y, Liu Q, Anrather J, Shi FD. Immune interventions in stroke. Nat Rev Neurol. 2015;11:524-535.
  7. Wang J. Preclinical and clinical research on inflammation after intracerebral hemorrhage. Prog Neurobiol. 2010;92:463-477.
  8. Temirbekov D, Sakallı E. Effects of peripheral vertigo on ınflammatory and ımmunologic laboratory markers. Ear, Nose & Throat Journal. 2020;99(7):470-474. doi:10.1177/0145561320920149
  9. Ozbay I, Kahraman C, Balikci HH, et al. Neutrophil-to-lymphocyte ratio in patients with peripheral vertigo: a prospective controlled clinical study. Am J Otolaryngol. 2014;35(6):699-702. doi:10.1016/j.amjoto.2014.08.004
  10. Lee SH, Yun SJ, Ryu S, et al. Utility of neutrophil-to-lymphocyte ratio (NLR) as a predictor of acute infarction in new-onset acute vertigo patients without neurologic and computed tomography abnormalities. J Emerg Med. 2018;54:607-614.
  11. Celikbilek A, Ismailogullari S, Zararsiz G. Neutrophil to lymphocyte ratio predicts poor prognosis in ischemic cerebrovascular disease. J Clin Lab Anal. 2014;28:27-31.
  12. Tokgoz S, Kayrak M, Akpinar Z, Seyithanoğlu A, Güney F, Yürüten B. Neutrophil lymphocyte ratio as a predictor of stroke. J Stroke Cerebrovasc Dis. 2013;22:1169-1174.
  13. Zhu RT, Van Rompaey V, Ward BK, Van de Berg R, Van de Heyning P, Sharon JD. the interrelations between different causes of dizziness: A conceptual framework for understanding vestibular disorders. Ann Otol Rhinol Laryngol. 2019;128(9):869-878. doi:10.1177/0003489419845014
  14. Hackenberg B, O'Brien K, Döge J, et al. Vertigo and its burden of disease-results from a population-based cohort study. Laryngoscope Investig Otolaryngol. 2023;8(6):1624-1630. doi:10.1002/lio2.1169
  15. Von Brevern M, Radtke A, Lezius F, et al. Epidemiology of benign paroxysmal positional vertigo: a population-based study. J Neurol Neurosurg Psychiatry. 2007;78:710-715.
  16. Lempert T, Neuhauser H. Epidemiology of vertigo, migraine and vestibular migraine. J Neurol. 2009;256(3):333-8. doi:10.1007/s00415-009-0149-2
  17. Gambacorta V, Ricci G, D'Orazio A, et al. Evaluation of cochlear symptoms in migraine patients without vestibular migraine and/or ménière's disease. Audiol Res. 2023;6;13(6):967-977. doi:10.3390/audiolres13060084
  18. Narita S, Kurose M, Kobayashi K, Himi T. Study on 242 inpatients reporting vertigo and dizziness. Nippon Jibiinkoka Gakkai Kaiho. 2003;106:21-27.
  19. Chawla N, Olshaker JS. Diagnosis and management of dizziness and vertigo. Med Clin North Am. 2006;90:291-304.
  20. Goldman B. Chapter- 231: Vertigo and dizziness. In: Tintinalli JE, Stapczynski JS, Ma OJ, Cline DM, Cydulka RK, Meckler GD eds. Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 6th Ed. America: The McGraw-Hill Companies; 2010.
  21. Tun NN, Arunagirinathan G, Munshi SK, Pappachan JM. Diabetes mellitus and stroke: A clinical update. World J Diabetes. 2017;8(6):235-248. doi:10.4239/wjd.v8.i6.235
  22. Steenerson KK. Acute vestibular syndrome. Continuum (Minneap Minn). 2021;1;27(2):402-419. doi:10.1212/CON.0000000000000958
  23. StatPearls. Vestibular Dysfunction. https://www.ncbi.nlm.nih.gov/books/NBK558926/. Accessed June, 2024.
  24. Swain K.S. Management of vertigo made easy. New Delhi, India: Jaypee Brothers Medical Publishers. 2016;29.
  25. Gibson WPR. Meniere's Disease. Adv Otorhinolaryngol. 2019;82:77-86. doi:10.1159/000490274
  26. Wang F, Hu S, Ding Y, et al. Neutrophil-to-lymphocyte ratio and 30-day mortality in patients with acute intracerebral hemorrhage. J Stroke Cerebrovasc Dis. 2016;25:182-187.
  27. Wang Z, Gong Q, Guo C, Luo Y, Chen L. Neutrophil-to-lymphocyte ratio predicts hematoma growth in intracerebral hemorrhage. J Int Med Res. 2019;47:2970-2975.