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Journals / Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi / 2026 / Volume: 13 Issue: 1

The Effect of Preoperative Low Albumin Level on Postoperative Outcomes After Pancreaticoduodenectomy

Preoperatif Düşük Albüminin Pankreatikoduodenektomi Sonrası Postoperatif Sonuçlara Etkisi

Akile Zengin(ESKİŞEHİR OSMANGAZİ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0003-0981-8901
Ahmet Murat Sendil(ESKISEHIR OSMANGAZI UNIVERSITY, SCHOOL OF MEDICINE)0000-0001-6307-5390
Yusuf Murat Bag(Ankara Eğitim ve Araştırma Hastanesi)0000-0002-0159-9356
Yavuz Selim Angın(ESKISEHIR OSMANGAZI UNIVERSITY, SCHOOL OF MEDICINE)0000-0001-5315-8360
Murat Ulaş(ESKISEHIR OSMANGAZI UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-3507-8647
Mehmet Kılıç(ESKISEHIR OSMANGAZI UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-4511-1527
Pages
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Publication Date
2026-04-29
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

So, lower albumin level (≤37.8 g/L) is associated with increased postoperative serious complications in PD for periampullar cancer.

📌 3 Key Takeaways

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Objective & Hypothesis:The preoperative identification of patients who are at high risk for serious postoperative outcomes after pancreaticoduodenectomy is important for their management.
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Key Findings & Data:Our aim was to investigate the factors affecting the serious complications after pancreaticoduodenectomy (PD). 92 patients who were operated for periampullar region tumor were retrospectively analyzed between November 2017 and July 2024.
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Conclusion & Impact:So, lower albumin level (≤37.8 g/L) is associated with increased postoperative serious complications in PD for periampullar cancer.
🔬Design:Research Article
📍Scope:2017 Verileri
⚙️Variables:CALLY · Hypoalbuminemia · Inflammatory burden index

Abstract

The preoperative identification of patients who are at high risk for serious postoperative outcomes after pancreaticoduodenectomy is important for their management. Our aim was to investigate the factors affecting the serious complications after pancreaticoduodenectomy (PD). 92 patients who were operated for periampullar region tumor were retrospectively analyzed between November 2017 and July 2024. Patients were divided into two groups (patients without serious complication (woSC) and patients with serious complication (wSC)) and these groups were compared with demographic data, laboratory results, pathological findings, perioperative findings, and 30-day mortality rate. Risk factors affecting postoperative serious complications were determined. Logistic regression analyses were performed to identify the risk factors of postoperative serious complication. Twenty-four (26%) patients developed serious complications after PD. The albumin levels were significantly lower in the wSC group compared with the woSC group (p=0.035). The albumin was found to be an independent factor in multivariate analysis. Receiver operating characteristic (ROC) curve analysis showed that 37.8 g/L was the optimal cut-off value for postoperative serious complication in PD. So, lower albumin level (≤37.8 g/L) is associated with increased postoperative serious complications in PD for periampullar cancer.

Özet

Pankreatikoduodenektomi (PD) sonrası ciddi postoperatif komplikasyon riski yüksek olan hastaların preoperatif olarak belirlenmesi, optimal yönetim için önemlidir. Bu çalışma, PD sonrası ciddi komplikasyonları etkileyen preoperatif faktörleri araştırmayı amaçlamaktadır. Periampüller bölge tümörü nedeniyle Kasım 2017 – Temmuz 2024 tarihleri arasında opere edilen 92 hasta retrospektif olarak incelendi. Hastalar ciddi komplikasyon yaşamayanlar (woSC) ve ciddi komplikasyon yaşayanlar (wSC) olmak üzere iki gruba ayrıldı. Gruplar demografik veriler, laboratuvar sonuçları, patolojik bulgular, perioperatif parametreler ve 30 günlük mortalite oranı açısından karşılaştırıldı. Postoperatif ciddi komplikasyonlar için risk faktörleri belirlendi. Postoperatif ciddi komplikasyonların risk faktörlerini belirlemek için lojistik regresyon analizi yapıldı. PD sonrası 24 hasta (%26) ciddi komplikasyon yaşadı. wSC grubunda albumin seviyeleri woSC grubuna göre anlamlı olarak daha düşüktü (p = 0.035) ve multivaryat analizde bağımsız bir risk faktörü olarak belirlendi. ROC analizi, ciddi postoperatif komplikasyonları öngörmede optimal kesme değerin 37.8 g/L olduğunu gösterdi. Sonuç olarak preoperatif düşük albumin seviyesi (≤37.8 g/L), periampuller kanser nedeniyle yapılan PD sonrası ciddi postoperatif komplikasyon riskinin artması ile ilişkilidir.

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Cite This Article

Zengin, A., Sendil, A. M., Bag, Y. M., Angın, Y. S., Ulaş, M., Kılıç, M. (2026). The Effect of Preoperative Low Albumin Level on Postoperative Outcomes After Pancreaticoduodenectomy. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, Volume: 13 Issue: 1. https://doi.org/10.47572/muskutd.1816313

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