Journals / Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi / 2026 / Volume: 13 Issue: 1

Hypertensive Disorders and Perinatal Outcomes According to Age Groups at Advanced Maternal Age

İleri Anne Yaşında Yaş Gruplarına Göre Hipertansif Bozukluklar ve Perinatal Sonuçlar

İsmail Bağlar(UNIVERSITY OF HEALTH SCIENCES, İSTANBUL KARTAL DR. LÜTFİ KIRDAR HEALTH RESEARCH CENTER, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY)0009-0008-0619-7111
Fatih Şanlıkan(UNIVERSITY OF HEALTH SCIENCES, İSTANBUL KARTAL DR. LÜTFİ KIRDAR HEALTH RESEARCH CENTER, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY)0000-0002-3166-7129
Esra Keles(UNIVERSITY OF HEALTH SCIENCES, İSTANBUL KARTAL DR. LÜTFİ KIRDAR HEALTH RESEARCH CENTER, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY)0000-0001-8099-8883
Uğur Kemal Öztürk(UNIVERSITY OF HEALTH SCIENCES, İSTANBUL KARTAL DR. LÜTFİ KIRDAR HEALTH RESEARCH CENTER, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY)0000-0003-0720-2919
Emre Mat(UNIVERSITY OF HEALTH SCIENCES, İSTANBUL KARTAL DR. LÜTFİ KIRDAR HEALTH RESEARCH CENTER, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY)0000-0002-3965-543X
Ahmet Özkul(UNIVERSITY OF HEALTH SCIENCES, İSTANBUL KARTAL DR. LÜTFİ KIRDAR HEALTH RESEARCH CENTER, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY)0009-0007-5116-3079
Pages
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Publication Date
2026-04-29
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Therefore, close antenatal monitoring, risk assessment, and implementation of appropriate prophylactic measures in advanced maternal age pregnancies are critical to reducing maternal and perinatal complications.

📌 3 Key Takeaways

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Objective & Hypothesis:The aim of this study was to conduct a comparative analysis of hypertensive disorders, pregnancy complications, and perinatal outcomes in advanced maternal age pregnancies.
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Key Findings & Data:The study was conducted using a retrospective cohort design, including 4203 pregnant women of advanced maternal age who delivered between 2010 and 2024.
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Conclusion & Impact:Therefore, close antenatal monitoring, risk assessment, and implementation of appropriate prophylactic measures in advanced maternal age pregnancies are critical to reducing maternal and perinatal complications.
🔬Design:Research Article
📍Scope:2010 Verileri
⚙️Variables:Advanced Maternal Age · Hypertensive Disorders · Perinatal Outcomes

Abstract

The aim of this study was to conduct a comparative analysis of hypertensive disorders, pregnancy complications, and perinatal outcomes in advanced maternal age pregnancies. The study was conducted using a retrospective cohort design, including 4203 pregnant women of advanced maternal age who delivered between 2010 and 2024. Patients were divided into three age groups: 35–39 years (n=3501), 40–44 years (n=608), and ≥45 years (n=94). Demographic characteristics, hypertensive disorders, pregnancy complications and perinatal outcomes were examined. Data were obtained retrospectively from the electronic record system and used in intergroup comparisons. The prevalence of hypertensive disorders increased significantly with age: 9.8% in the 35–39 age group, 16.7% in the 40–44 age group, and 27.6% in the ≥45 age group (p<0.001). Preeclampsia and superimposed hypertension were particularly prevalent. Preeclampsia was significantly higher in the ≥45 age group. From a perinatal perspective, the rates of preterm birth (12.4%, 18.5%, and 27.7%), IUGR (6.1%, 9.8%, and 15.9%), and SGA (7.2%, 10.3%, and 18.1%) gradually increased with age. Mean birth weight decreased from 3150 g to 2890 g, and the NICU admission rate increased from 9.3% to 22.3%. Perinatal mortality was also highest in the ≥45 age group at 3.1%. Hypertensive disorders and perinatal complications increase with age in pregnancies of advanced maternal age. The ≥45 age group, in particular, should be considered high-risk. Therefore, close antenatal monitoring, risk assessment, and implementation of appropriate prophylactic measures in advanced maternal age pregnancies are critical to reducing maternal and perinatal complications.

Özet

Bu çalışmanın amacı, ileri anne yaşı gebeliklerinde hipertansif bozukluklar, gebelik komplikasyonları ve perinatal sonuçların karşılaştırmalı analizini yapmaktır. Çalışma, 2010-2024 yılları arasında doğum yapan ileri anne yaşındaki 4.203 gebeyi içeren retrospektif kohort tasarımında yürütülmüştür. Hastalar üç yaş grubuna ayrılmıştır: 35-39 yaş (n=3501), 40-44 yaş (n=608) ve ≥45 yaş (n=94). Demografik özellikler, hipertansif bozukluklar, gebelik komplikasyonları ve perinatal sonuçlar incelenmiştir. Veriler elektronik kayıt sisteminden retrospektif olarak elde edilmiştir. Hipertansif bozuklukların yaygınlığı yaşla birlikte önemli ölçüde arttı: 35-39 yaş grubunda %9.8, 40-44 yaş grubunda %16.7 ve ≥45 yaş grubunda %27.6 (p<0.001). Preeklampsi ve üst üste binen hipertansiyon özellikle yaygındı. Preeklampsi ≥45 yaş grubunda önemli ölçüde daha yüksekti. Perinatal açıdan, preterm doğum (%12.4, %18.5 ve %27.7), IUGR (%6.1, %9.8 ve %15.9) ve SGA (%7.2, %10.3 ve %18.1) oranları yaşla birlikte kademeli olarak arttı. Ortalama doğum ağırlığı 3150 g'dan 2890 g'a düştü ve NICU'ya yatış oranı %9.3'ten %22.3'e yükseldi. Perinatal mortalite de %3.1 ile ≥45 yaş grubunda en yüksekti. Hipertansif bozukluklar ve perinatal komplikasyonlar, ileri anne yaşı olan gebeliklerde yaşla birlikte artmaktadır. Özellikle ≥45 yaş grubu yüksek riskli grup olarak değerlendirilmelidir. Bu nedenle, ileri anne yaşı olan gebeliklerde yakın antenatal takip, risk değerlendirmesi ve uygun profilaktik önlemlerin uygulanması, maternal ve perinatal komplikasyonları azaltmada kritik öneme sahiptir.

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Cite This Article

Bağlar, İ., Şanlıkan, F., Keles, E., Öztürk, U. K., Mat, E., Özkul, A. (2026). Hypertensive Disorders and Perinatal Outcomes According to Age Groups at Advanced Maternal Age. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, Volume: 13 Issue: 1. https://doi.org/10.47572/muskutd.1774358

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