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Journals / Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi / 2026 / Volume: 13 Issue: 2

Comparison of Prediction Formulas for CPAP Titration in Patients with Sleep Apnoea Syndrome

Uyku Apne Sendromlu Hastalarda CPAP Titrasyonu İçin Tahmin Formüllerinin Karşılaştırılması

Furkan Sarıdaş(BURSA ULUDAĞ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-5945-2317
Aylin Bican Demir(BURSA ULUDAĞ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-6739-8605
Pages
—
Publication Date
2026-08-27
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Overall, the Loredo formula demonstrated superior accuracy in predicting CPAP titration pressures, suggesting that it may be a reliable alternative to manual titration methods in clinical practice.

📌 3 Key Takeaways

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Objective & Hypothesis:Continuous Positive Airway Pressure (CPAP) therapy has revolutionized the treatment of Obstructive Sleep Apnea Syndrome (OSAS), first reported in 1981.
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Key Findings & Data:This study aims to compare the effectiveness of three widely used prediction formulas—Hoffstein, Loredo et al., and Hukins—against manually titrated CPAP pressure values in patients diagnosed with OSAS.
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Conclusion & Impact:Overall, the Loredo formula demonstrated superior accuracy in predicting CPAP titration pressures, suggesting that it may be a reliable alternative to manual titration methods in clinical practice.
🔬Design:Research Article
📍Scope:2010 Verileri
⚙️Variables:CPAP titration · OSAS · Prediction formulas

Abstract

Continuous Positive Airway Pressure (CPAP) therapy has revolutionized the treatment of Obstructive Sleep Apnea Syndrome (OSAS), first reported in 1981. Manual CPAP titration can lead to a number of constraints and loss of time and labor for the patient and relatives, the healthcare worker, and the healthcare system. Therefore, the use of predictive forecasting formulas has a positive benefit. This study aims to compare the effectiveness of three widely used prediction formulas—Hoffstein, Loredo et al., and Hukins—against manually titrated CPAP pressure values in patients diagnosed with OSAS. The study included 69 patients first diagnosed with OSAS in our center's polysomnography (PSG) laboratory between 2010 and 2024 and underwent CPAP titration during a whole-night sleep study. Three predictive formulas were compared, and their agreement with manual titration was evaluated. The comparison of predicted pressures revealed that the Loredo formula provided the closest estimates to manual titration pressures, showing the least systematic difference (-0.07101) and absolute percentage error (11.11%). In contrast, the Hoffstein formula exhibited the highest systematic difference (-2.4174), while the Hukins formula had moderate predictive validity. Overall, the Loredo formula demonstrated superior accuracy in predicting CPAP titration pressures, suggesting that it may be a reliable alternative to manual titration methods in clinical practice. Future research should focus on validating these formulas across larger and more diverse populations to enhance their applicability in routine clinical settings.

Özet

Sürekli Pozitif Hava Yolu Basıncı (CPAP) tedavisi, ilk kez 1981 yılında bildirilen Obstrüktif Uyku Apne Sendromu (OSAS) tedavisinde devrim yaratmıştır. Manuel CPAP titrasyonu, hasta ve yakınları, sağlık çalışanı ve sağlık sistemi için bir dizi kısıtlamaya ve zaman ve iş gücü kaybına yol açabilir. Bu nedenle, öngörücü tahmin formüllerinin kullanılmasının olumlu bir yararı vardır. Bu çalışmanın amacı, OSAS tanılı hastalarda manuel olarak titre edilen CPAP basınç değerlerine karşı yaygın olarak kullanılan üç tahmin formülünün (Hoffstein, Loredo ve ark. ve Hukins) etkinliğini karşılaştırmaktır. Çalışmaya 2010-2024 yılları arasında merkezimizin polisomnografi (PSG) laboratuvarında ilk kez OUAS tanısı alan ve tüm gece uyku çalışması sırasında CPAP titrasyonu yapılan 69 hasta dahil edildi. Üç prediktif formül karşılaştırıldı ve manuel titrasyon ile uyumları değerlendirildi. Tahmini basınçların karşılaştırılması, Loredo formülünün manuel titrasyon basınçlarına en yakın tahminleri sağladığını, en az sistematik farkı (-0.07101) ve mutlak yüzde hatayı (%11.11) gösterdiğini ortaya koydu. Buna karşılık, Hoffstein formülü en yüksek sistematik farkı (-2.4174) sergilerken, Hukins formülü orta düzeyde tahmin geçerliliğine sahipti. Genel olarak, Loredo formülü CPAP titrasyon basınçlarını tahmin etmede üstün doğruluk göstermiştir ve klinik uygulamada manuel titrasyon yöntemlerine güvenilir bir alternatif olarak hizmet edebileceğini düşündürmektedir. Gelecekteki araştırmalar, rutin klinik ortamlarda uygulanabilirliklerini artırmak için bu formülleri daha geniş ve daha çeşitli popülasyonlarda doğrulamaya odaklanmalıdır.

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Cite This Article

Sarıdaş, F., Demir, A. B. (2026). Comparison of Prediction Formulas for CPAP Titration in Patients with Sleep Apnoea Syndrome. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, Volume: 13 Issue: 2. https://doi.org/10.47572/muskutd.1642988

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