Journals / Bakırköy Tıp Dergisi / 2013 / Cilt: 9 - Sayı: 4

Intrahepatic cholestasis of pregnancy: Evaluation of maternal & fetal outcomes of 33 pregnancies

İntrahepatik gebelik kolestazı: 33 vakanın maternal ve fetal sonuçlarının değerlendirilmesi

Pages
171–175
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Treatment and pregnancy management should be planned due to patient’s condition with close antenatal fetal and maternal monitoring.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To evaluate maternal-fetal outcomes of the pregnancies complicated by intrahepatic cholestasis and to discuss the pregnancy management.
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Key Findings & Data:Material and Methods: Medical records of 33 patients diagnosed as intrahepatic cholestasis of pregnancy between January 2006 and December 2009 were retrospectively evaluated in this study.
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Conclusion & Impact:Treatment and pregnancy management should be planned due to patient’s condition with close antenatal fetal and maternal monitoring.
🔬Design:Research Article
📍Scope:2006 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: To evaluate maternal-fetal outcomes of the pregnancies complicated by intrahepatic cholestasis and to discuss the pregnancy management. Material and Methods: Medical records of 33 patients diagnosed as intrahepatic cholestasis of pregnancy between January 2006 and December 2009 were retrospectively evaluated in this study. Results: The mean age, gestational age, exposure time, the gestational age on delivery time of 33 patients (31 single & 2 twin pregnancies) followed at Perinatology Clinic were 26±5.48 years, 34.4±3.5 weeks, 24.2±19.4 days, 36.1±3.1 weeks, respectively. Sixteen patients (48.5%) delivered with cesarean section. Among these patients, cesarean delivery was performed with a diagnosis of fetal distress in 6 patients (37.5%) and 3 of these neonates were followed at neonatal intensive care unit (NICU). The mean birth weight was 2788.6±609.3 gr and the admission rate of NICU was 77.7% with a diagnosis of prematurity in 9 patients (27.3%). Apgar scores were lower than 7 in 8 patients (24%) at 1 minute and lower than 7 in 4 patients (12%) at 5 minutes, no stillbirths were determined. Conclusion: Intrahepatic cholestasis of pregnancy is important with its fetal risks rather than maternal effects. Treatment and pregnancy management should be planned due to patient’s condition with close antenatal fetal and maternal monitoring.

Özet

Amaç: İntrahepatik kolestaz tanısıyla takip edilmiş olan hastaların maternal-fetal sonuçlarının değerlendirilmesi ve gebelik yönetiminin tartışılması. Gereç ve Yöntem: Ocak 2006 ile Aralık 2009 yılları arasında kliniğimizde intrahepatik kolestaz tanısıyla takip edilmiş olan 33 hastanın tıbbi kayıtları retrospektif olarak değerlendirildi. Bulgular: İntrahepatik kolestaz tanısıyla Perinatoloji Kliniği’nde takip edilen 33 hastanın (31 tekil, 2 ikiz) ortalama yaşları 26±5.48, tanı sırasındaki ortalama gestasyonel yaşları 34.4±3.5 hafta, hastalığa maruz kalma süresi 24.2±19.4 gün, doğumdaki ortalama gestasyonel yaşları 36.1±3.1 hafta olarak saptandı. On altı hasta (%48.5) sezaryen ile doğurtuldu. Altı hastada (%37.5) fetal distress tanısıyla sezaryen gerçekleştirildi, bu hastaların 3’ü yenidoğan yoğun bakım ünitesinde izlendi. Ortalama doğum kilosu 2788.6±609.3 gr idi. Yenidoğan yoğun bakım ünitesine kabul oranı prematürite (%77.7) sebebiyle 9 hastada (%27.3) gerçekleşti. Sekiz hastanın (%24) 1. dakika Apgar skorları 7’nin altında iken, 5. dakika Apgar skoru 4 hastada (%12) 7’nin altında izlendi, yenidoğan ölü doğum saptanmadı. Sonuç: Gebelik intrahepatik kolestazı maternal etkilerinin aksine taşıdığı fetal riskler açısından önemlidir. Yakın antenatal fetal ve maternal izlem ile, tedavi ve doğum süreci hastaya göre planlanmalıdır.

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Cite This Article

KIYKAÇ, Ş. A., KARCAALTINCABA, D., KANDEMİR, Ö., YALVAÇ, S. (2013). Intrahepatic cholestasis of pregnancy: Evaluation of maternal & fetal outcomes of 33 pregnancies. Bakırköy Tıp Dergisi, Cilt: 9 - Sayı: 4, 171–175. https://ajindex.com/articles/129131

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