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Journals / Meandros Medical And Dental Journal / 2026 / Volume: 23 Issue: 1

Effect of Pediatric Toothpastes Based on 500 to 1450 ppm Sodium Fluoride and Amine Fluoride with Different Detergents on Oxidative Stress and Cell Viability

Firdevs Kahvecioğlu(SELCUK UNIVERSITY)
Hayriye Esra Ülker(SELCUK UNIVERSITY)
Gül Tosun(SELCUK UNIVERSITY)
Mutlu Özcan
Pages
—
Publication Date
2022-03-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Pediatric toothpastes containing sodium fluoride with sodium lauryl sulfate presented more cytotoxic effect.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: This study evaluated the effect of sodium fluoride and amine fluoride pediatric toothpastes with different detergents on oxidative stress and cell viability.
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Key Findings & Data:L929 fibroblast cells were exposed to toothpaste extracts at 37 °C for 2 min.
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Conclusion & Impact:Conclusion: Pediatric toothpastes containing sodium fluoride with sodium lauryl sulfate presented more cytotoxic effect.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Cytotoxicity · pediatric dentistry · reactive oxygen species

Abstract

Objective: This study evaluated the effect of sodium fluoride and amine fluoride pediatric toothpastes with different detergents on oxidative stress and cell viability. Materials and Methods: Pediatric toothpastes containing sodium fluoride (Sensodyne Pronamel-SP; Ipana Kids-IK; Signal Kids-SK; Oral B-OB) and amine fluoride (Elmex-EL; Elmex Junior-EJ) were obtained. While SP, IK, EL contained cocamidopropyl betaine detergent, SK, OB sodium lauryl sulfate and EJ had olaflur detergents. Toothpaste samples were diluted with medium at different predetermined concentrations. L929 fibroblast cells were exposed to toothpaste extracts at 37 °C for 2 min. Cell viability was tested using methyl tetrazolium test, while the formation of reactive oxygen species (ROS) was detected using flow cytometry. Results: The decreasing concentration ratio from 1:1 to 1:32 decreased the cytotoxicity (p 0.05). All toothpastes tested increased the number of ROS in L929 cells (p<0.05). Conclusion: Pediatric toothpastes containing sodium fluoride with sodium lauryl sulfate presented more cytotoxic effect.

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Cite This Article

Kahvecioğlu, F., Ülker, H. E., Tosun, G., Özcan, M. (2022). Effect of Pediatric Toothpastes Based on 500 to 1450 ppm Sodium Fluoride and Amine Fluoride with Different Detergents on Oxidative Stress and Cell Viability. Meandros Medical And Dental Journal, Volume: 23 Issue: 1. https://doi.org/10.4274/meandros.galenos.2021.65982

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