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Journals / Bakırköy Tıp Dergisi / 2016 / Cilt: 12 - Sayı: 2

Toxic hepatitis associated with amoxicillin-clavulanic acid in a chronic viral hepatitis B patient: a case report

Kronik Viral Hepatit B Tanısı Olan Hastada Amoksisilin-Klavulonik Asit Kullanımına Bağlı Gelişen Toksik Hepatit: Olgu Sunumu

Pervin Özkan KURTGÖZ
Havva TÜNAY
Fatma KURBAN
Serkan KURTGÖZ
Kasım DEMİR
Gürsel ACARTÜRK
Pages
92–95
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

When ACA was discontinued, the patient's symptomps improved and her liver enzyme levels reduced to near to the normal range.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Amoxicillin-clavulanic acid (ACA) related hepatotoxicity is among the most common causes of drug-related hepatotoxicity.
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Key Findings & Data:Symptoms usually begin 1-4 weeks after ingestion and heal within 8 weeks.
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Conclusion & Impact:When ACA was discontinued, the patient's symptomps improved and her liver enzyme levels reduced to near to the normal range.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Amoxicillin-clavulanic acid (ACA) related hepatotoxicity is among the most common causes of drug-related hepatotoxicity. Cholestatic liver injury is the most common type. Symptoms usually begin 1-4 weeks after ingestion and heal within 8 weeks. Rarely develop fulminant hepatitis and death. In this study, we present a case of a 62-year-old woman who had chronic viral hepatitis B and developed toxic hepatitis after receiving ACA treatment. When ACA was discontinued, the patient's symptomps improved and her liver enzyme levels reduced to near to the normal range.

Özet

Amoksisilin klavulonik asit (AKA) ilişkili hepatotoksisite, ilaç ilişkili hepatotoksisitenin en sık sebepleri arasındadır. Karaciğer hasarı en sık kolestatik tiptedir. Semptomlar genelde ilaç alımından 1-4 hafta sonra başlar ve 8 hafta içinde iyileşir. Nadiren fulminan hepatit ve ölüm gelişir. Bu çalışmada kronik hepatit B tanısı olan ve AKA tedavisi sonrası toksik hepatit gelişen 62 yaşında bayan bir hasta sunuldu. AKA tedavisi kesildiğinde hastanın semptomları geriledi, karaciğer enzimleri normal seviyelere yakın düzeldi.

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Cite This Article

KURTGÖZ, P. Ö., TÜNAY, H., KURBAN, F., KURTGÖZ, S., DEMİR, K., ACARTÜRK, G. (2016). Toxic hepatitis associated with amoxicillin-clavulanic acid in a chronic viral hepatitis B patient: a case report. Bakırköy Tıp Dergisi, Cilt: 12 - Sayı: 2, 92–95. https://ajindex.com/articles/128721

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