Journals / Marmara Medical Journal / 2026 / Volume: 30 Issue: 2

The role of magnetic resonance diffusion tensor imaging in differentiation of benign from malignant focal renal lesions

Fokal renal lezyonlarının benign ve malign ayırımında manyetik rezonans difüzyon tensör görüntülemenin rolü

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Publication Date
2017-05-14
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Malignant renal lesions have low ADCs and high Fa values, whereas benign renal lesions have high ADCs and low Fa values.

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Objective & Hypothesis:Objectives: To determine the diagnostic performance of apparent diffusion coefficient (ADC) and fractional anisotropy (Fa) measurements in differentiation of malignant from benign focal renal lesions.
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Key Findings & Data:Material and Methods: Twenty-one patients (9 women and 12 men ; mean age 54,1 years) with 25 focal renal lesions diagnosed by different imaging modalities such as computed tomography (CT) and ultrasound (US) and examined with magnetic resonance diffusion tensor imaging (DTI) were included in the study.
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Conclusion & Impact:Malignant renal lesions have low ADCs and high Fa values, whereas benign renal lesions have high ADCs and low Fa values.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Magnetic resonance · Diffusion tensor · Renal lesion

Abstract

Objectives: To determine the diagnostic performance of apparent diffusion coefficient (ADC) and fractional anisotropy (Fa) measurements in differentiation of malignant from benign focal renal lesions. Material and Methods: Twenty-one patients (9 women and 12 men ; mean age 54,1 years) with 25 focal renal lesions diagnosed by different imaging modalities such as computed tomography (CT) and ultrasound (US) and examined with magnetic resonance diffusion tensor imaging (DTI) were included in the study. There were 6 solid renal cell carcinomas (RCC), 1 cystic RCC, 1 angiomyolipoma (AML) and 17 cystic lesions ( 16 Bosniak type I cysts, 1 Bosniak type II cyst). ADC and Fa measurements were performed by two radiologists, in consensus. The differences in ADC and Fa values of malignant and benign renal lesions were compared using ANOVA and Tukey tests. A ROC analysis was applied; sensitivities and specificities were calculated. Results: The mean ADC and Fa values of malignant lesions were 1.29±0.4 mm2/sec and 0.34±0.1, respectively. The mean ADC and Fa values of benign lesions were 2.6±0.7 mm2/sec and 0.19±0.12, respectively. The differences were significant (P<0.05). The Az values for discriminating malignant lesions from benign ones for ADC and Fa value were 0.95 and 0.83, respectively.&nbsp;The sensitivity-specificity of ADC and Fa were 100%-83.3%, and 100%-77.8%, respectively. Conclusion: There are statistically 2l significant differences between ADC and Fa values of malignant and benign focal renal lesions. Malignant renal lesions have low ADCs and high Fa values, whereas benign renal lesions have high ADCs and low Fa values.

Özet

Amaç: Fokal böbrek lezyonlarının benign, malign ayırımında görünüşteki difüzyon katsayısı (apparent diffusion coefficient - ADC) ve fraksiyonel anizotropi (Fa) ölçümlerinin diagnostik performanslarının belirlenmesi. Gereç ve Yöntem: Çalışmamıza, bilgisayarlı tomografi (BT) ve ultrason (US) gibi değişik görüntüleme modaliteleri ile tanı konulan ve manyetik rezonans diffüzyon tensör görüntülemesi (DTI) yapılmış 21 hastada (9 kadın and 12 erkek ; ortalama yaş 54,1 ), 25 fokal renal lezyon dahil edildi. Lezyonlar 6 solid renal hücreli karsinom (RCC), 1 kistik RCC, 1 anjiomyolipom (AML) ve 17 kistik lezyondan ( 16 Bosniak tip I kist, 1 Bosniak tip II kist) oluşmaktaydı. ADC ve Fa ölçümleri iki radyolog tarafından, konsensusa varılarak yapıldı. Malign ve benign lezyonlara ait ADC ve Fa değerleri ANOVA ve Tukey testleri kullanılarak karşılaştırıldı. ROC analizi kullanıldı; sensitivite ve spesifite hesaplandı. Bulgular: Malign lezyonların ortalama ADC ve Fa değerleri sırasıyla 1.29±0.4 mm2/sn ve 0.34±0.1 ölçüldü. Benign lezyonların ortalama ADC ve Fa değerleri sırasıyla 2.6±0.7 mm2/sn ve 0.19±0.12 ölçüldü. Aralarındaki fark istatistiksel olarak anlamlı idi (P<0.05). Malign lezyonları, benign lezyonlardan ayırmada ADC ve Fa ölçümlerinin, Az değerleri sırasıyla 0.95 ve 0.83 bulundu. ADC ve Fa ölçümlerinin sensitivite ve spesifite değerleri sırasıyla 100%-83.3% ve 100%-77.8% bulundu. Sonuç: Malign ve benign fokal renal lezyonların ADC ve Fa ölçümleri değerleri arasında istatistiksel anlamlı farklar mevcuttur. Malign renal lezyonlarda düşük ADC ve yüksek Fa değerleri izlenirken, benign renal lezyonlarda yüksek ADC ve düşük Fa değerleri izlenir.

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Cite This Article

Erturk, S. M., Uzunoglu, F. Y., Mahmutoglu, A. S., Ugurlar, O. Y., Ozdıl, G., Ozel, A., Kırdar, O., Basak, M. (2017). The role of magnetic resonance diffusion tensor imaging in differentiation of benign from malignant focal renal lesions. Marmara Medical Journal, Volume: 30 Issue: 2. https://doi.org/10.5472/marumj.344825

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