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Journals / Marmara Medical Journal / 2026 / Volume: 33 Issue: 2

The role of diffusion tensor imaging for the assessment of liver fibrosis and inflammation in chronic viral hepatitis: A preliminary study

Ozge Yapıcı Ugurlar(ŞİŞLİ ETFAL TRAINING AND RESEARCH HOSPITAL)
Mehmet Sait Bugdaycı(ŞİŞLİ ETFAL TRAINING AND RESEARCH HOSPITAL)
Abdullah Soydan Mahmutoglu(ŞİŞLİ ETFAL TRAINING AND RESEARCH HOSPITAL)
Canan Alkım(ŞİŞLİ ETFAL TRAINING AND RESEARCH HOSPITAL)
Banu Yılmaz Ozguven(ŞİŞLİ ETFAL TRAINING AND RESEARCH HOSPITAL)
Alper Ozel(ŞİŞLİ ETFAL TRAINING AND RESEARCH HOSPITAL)
Muzaffer Basak(ŞİŞLİ ETFAL TRAINING AND RESEARCH HOSPITAL)
Yasin Aykut(ŞİŞLİ ETFAL TRAINING AND RESEARCH HOSPITAL)
Huseyin Ozkurt(ŞİŞLİ ETFAL TRAINING AND RESEARCH HOSPITAL)
Sukru Mehmet Erturk(ŞİŞLİ ETFAL TRAINING AND RESEARCH HOSPITAL)
Pages
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Publication Date
2020-05-31
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Diffusion tensor imaging may play a role in the evaluation of fibrosis and HAI scores in patients with liver fibrosis.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: To evaluate the role of magnetic resonance (MR) diffusion tensor imaging (DTI) in the assessment of liver fibrosis and inflammation in chronic viral hepatitis by measuring apparent diffusion coefficient (ADC) and fractional anisotropy (Fa) values.
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Key Findings & Data:Material and Methods: Twenty-seven patients (5 women and 22 men;mean age39.8±11.3) with hepatic fibrosis were included in our study.
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Conclusion & Impact:Conclusion: Diffusion tensor imaging may play a role in the evaluation of fibrosis and HAI scores in patients with liver fibrosis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Hepatitis · Liver fibrosis · Diffusion tensor imaging

Abstract

Objective: To evaluate the role of magnetic resonance (MR) diffusion tensor imaging (DTI) in the assessment of liver fibrosis and inflammation in chronic viral hepatitis by measuring apparent diffusion coefficient (ADC) and fractional anisotropy (Fa) values. Material and Methods: Twenty-seven patients (5 women and 22 men;mean age39.8±11.3) with hepatic fibrosis were included in our study. The relationship between ADC, Fa values and histological activity index (HAI) score were evaluated using Spearman’s correlation coefficient. Patients were subgrouped as group A (fibrosis score 1) and group B (fibrosis score 3). The mean ADC and Fa values of groups A and B were compared using Student’s t-test. To evaluate the use of ADC and Fa values in distinguishing group A from group B, ROC analysis was applied; sensitivities and specificities were calculated. Results: Fa values correlated with HAI scores significantly (r=0.397, p<0.05) The difference was significant between the mean ADC values (group A:1.46± 0.191x103mm2/s; group B:1.105± 0.141x10-3 mm2/s; p<0.001) and Fa values (group A: 0.473±0.091; group B: 0.643± 0.007; p<0.001) between the groups. For distinguishing group A from group B, ADC had a sensitivity of 81.8% and a specificity of 93.8%. The sensitivity and specificity of Fa were 90.9% and 100%, respectively. Conclusion: Diffusion tensor imaging may play a role in the evaluation of fibrosis and HAI scores in patients with liver fibrosis.

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Cite This Article

Ugurlar, O. Y., Bugdaycı, M. S., Mahmutoglu, A. S., Alkım, C., Ozguven, B. Y., Ozel, A., Basak, M., Aykut, Y., Ozkurt, H., Erturk, S. M. (2020). The role of diffusion tensor imaging for the assessment of liver fibrosis and inflammation in chronic viral hepatitis: A preliminary study. Marmara Medical Journal, Volume: 33 Issue: 2. https://doi.org/10.5472/marumj.741724

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