Plasma Calprotectin Values in Acute Pancreatitis

Objective & Hypothesis:Plasma calprotectin values in acute pancreatitisObjective: To investigate the usefulness of the plasma calprotectin values for diagnosis of acute pancreatitis.

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Key Findings & Data:Material and Methods: 84 patients who have been diagnosed as acute pancreatitis (AP) were included in this prospective study.

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Conclusion & Impact:Further studies are needed with larger number of patients who were classified according to the severity of AP

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Plasma calprotectin values in acute pancreatitisObjective: To investigate the usefulness of the plasma calprotectin values for diagnosis of acute pancreatitis. Material and Methods: 84 patients who have been diagnosed as acute pancreatitis (AP) were included in this prospective study. Control group (CG) included 30 patients with elective surgery for inguinal hernia or pilonidal sinus. Male to female ratio was 36/48 with a mean age of 44 for AP group and male to female ratio was 20/10 with a mean age of 31 for control group. Blood samples were taken to EDTA coated tube and then aliquots of serum were stored at -80°C for assaying. Serum Cal was determined using Cal ELISA Kit.Results: Cal values were significantly higher in AP cases than in control group (p=0.001), value range from 32 to 490 ng/ml. There was a statistically positive significant relationship between cal and WBC values (r=0.423 p=0.0001), between cal and CRP values (r=0.282 p=0.012), between cal and amylase values (r=0.675 p=0.0001), between cal and lipase values (r=0.595 p=0.0001).Conclusions: Plasma calprotectin levels increase nonspecifically with AP. Further studies are needed with larger number of patients who were classified according to the severity of AP

Özet

Amaç: Plasma calprotectin değerinin akut pankreatit tanısında kullanılabilirliğini araştırmak. Gereç ve Yöntem: Bu prospektif çalışmaya akut pankreatit tanılı 84 hasta dahil edildi. Erkek/kadın oranı 36/48, ortlama yaş 44 ' idi. Kontrol grubuna kasık fıtığı ve pilonidal sinüs operasyonu olacak 30 hasta dahil edildi. Erkek/kadın oranı 20/10, ortalama yaş 31 idi . Kan örnekleri EDTA'lı tüpe alınıp plazmaları ayrıldıktan sonra -80°C'de saklandı. Plasma cal değeri ELISA yöntemi ile çalışıldı.Bulgular: Cal değerleri 32 ile 490 ng/ml arasında değişken ve AP vakalarında kontrol grubuna oranla belirgin bir şekilde yüksekti (p=0.001). Cal ve WBC değerleri (r=0.423 p=0.0001), cal ve CRP değerleri (r=0.282 p=0.012), cal ve amilaz değerleri (r=0.675 p=0.0001), cal ve lipaz değerleri (r=0.595 p=0.0001) arasında istatistiksel olarak anlamlı, pozitif bir ilişki vardı.Sonuç: Plasma calprotectin seviyesi akut pankreatitte nonspesifik olarak artmaktadır. Pankreatitin şiddetini değerlendirmede sınıflandırılmış hasta grupları üzerinde çalışmalara ihtiyaç vardır

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Cite This Article

ÇİKOT, M., GEDİKBAŞI, A., KÖNEŞ, O., KARABULUT, M., KOCATAŞ, A., AKARSU, C., TEMİZGÖNÜL, K. B., KAPAN, S., ALIŞ, H. (2016). Plasma Calprotectin Values in Acute Pancreatitis. Bakırköy Tıp Dergisi, Cilt: 12 - Sayı: 1, 11–15. https://ajindex.com/articles/128497

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