Journals / Bakırköy Tıp Dergisi / 2017 / Cilt: 13 - Sayı: 4

Quantitative Analysis of Lead and Nickel in Benign Meningioma and Glioblastoma Multiforme

İyi huylu meningiom ve glioblastoma multiformede kurşun ve nikel düzeylerinin kantitatif analizi

Pages
190–194
DOI
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We consider that our findings carry valuable data for new researches and can contribute to worthwhile information on pathogenesis of meningioma and glioblastoma multiforme.

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Objective & Hypothesis:Quantitative analysis of lead and nickel in benign meningioma and glioblastoma multiformeObjective: The aim of this study was to compare lead (Pb) and nickel (Ni) levels in tissue samples of benign meningiomas and glioblastoma multiformes.
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Key Findings & Data:Material and Methods: This study was performed in pathologically diagnosed benign meningioma and glioblastoma multiforme specimens (20 specimens in each group and a total of 40 specimens) obtained from operations.
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Conclusion & Impact:We consider that our findings carry valuable data for new researches and can contribute to worthwhile information on pathogenesis of meningioma and glioblastoma multiforme.
🔬Design:Research Article
📍Scope:20 specimens
⚙️Variables:Domain Parameters

Abstract

Quantitative analysis of lead and nickel in benign meningioma and glioblastoma multiformeObjective: The aim of this study was to compare lead (Pb) and nickel (Ni) levels in tissue samples of benign meningiomas and glioblastoma multiformes. Material and Methods: This study was performed in pathologically diagnosed benign meningioma and glioblastoma multiforme specimens (20 specimens in each group and a total of 40 specimens) obtained from operations. Measurements of trace elements were performed with Shimadzu AA 680 atomic absorption spectrophotometer. p<0.05 was considered as statistically significant. Results: The level of lead in benign meningioma specimens was similar to that in glioblastoma multiforme specimens (p=0.817). The level of nickel in benign meningioma specimens were statistically higher than that in glioblastoma multiforme specimens (p=0.003).Conclusion: The high Nickel content of benign meningiomas compared to that of glioblastoma multiformes and the possible correlation of nickel with meningioma formation should be further evaluated. We consider that our findings carry valuable data for new researches and can contribute to worthwhile information on pathogenesis of meningioma and glioblastoma multiforme.

Özet

Amaç: Bu çalışmanın amacı, iyi huylu meningiomlar ve glioblastoma multiforme doku örnekleri içerisindeki kurşun ve nikel seviyelerini karşılaştırmaktır. Gereç ve Yöntemler: Bu çalışma, patolojik olarak iyi huylu olarak teşhis edilmiş ve cerrahi operasyonla elde edilmiş meningiom ve glioblastoma multiforme örnekleri üzerinde gerçekleştirilmiştir (her gruptan 20 örnek). Eser elementlerin ölçümü Shimadzu AA 680 atomik absorpsiyon spektrometresi ile gerçekleştirilmiştir. Değerlendirme, her gruptaki kurşun ve nikel seviyseindeki değişimle, p<0.05 istatistiksel anlamlılık içerisinde yapılmıştır.Bulgular: İyi huylu meningiom örneklerindeki kurşun seviyesi glioblastoma multiforme örnekleriyle benzerdir (p=0.817). Nikel seviyesi ise iyi huylu meningiomlarda, glioblastoma multiforme örneklerine göre istatistiksel olarak yüksektir (p=0.003).Sonuç: Glioblastoma multiformelerler ile karşılaştırıldığında iyi huylu meningiomlardaki yüksek nikel içeriği ve nikelin meningiom oluşumundaki muhtemel korelasyonu araştırılmalıdır. Bulgularımızın yeni çalışmalar için değerli bir veri olduğunu ve meningiom ve glioblastoma multiforme patojenezi hakkında önemli bilgi katkısında bulunacağı kanaatindeyiz.

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Cite This Article

ADİLAY, H. U., GÜNAL, M., TANRIVERDİ, O., GÜLER, A. K., GÜÇLÜ, B., DEMİRGİL, B. (2017). Quantitative Analysis of Lead and Nickel in Benign Meningioma and Glioblastoma Multiforme. Bakırköy Tıp Dergisi, Cilt: 13 - Sayı: 4, 190–194. https://ajindex.com/articles/128291

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