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Journals / TSK Koruyucu Hekimlik Bülteni / 2014 / Cilt: 13 - Sayı: 1

Anti-cyclic Citrullinated Peptide Antibody (Anti-CCP) and Diagnostic Value for Rheumatoid Arthritis

Anti-siklik Sitrüllinlenmiş Peptid/Protein (Anti-CCP) ve Romatoid Artrit Tanısındaki Değeri

Mehmet AĞILLI
Şafak EKİNCİ
Fevzi Nuri AYDIN
İrfan ŞENER
Adem PARLAK
Halil YAMAN
Pages
83–88
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Due to the prescence of ACPA was included to 2010 RA diagnostic criteria, in a manner of speaking, importance of anti-CCP was registered

📌 3 Key Takeaways

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Objective & Hypothesis:Rheumatoid arthritis (RA) is an inflammatory multisystem disease of unknown etiology characterized by chronic destructive synovitis.
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Key Findings & Data:It's prevalence is about 1% all over the world.
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Conclusion & Impact:Due to the prescence of ACPA was included to 2010 RA diagnostic criteria, in a manner of speaking, importance of anti-CCP was registered
🔬Design:Research Article
📍Scope:2010 Verileri
⚙️Variables:Domain Parameters

Abstract

Rheumatoid arthritis (RA) is an inflammatory multisystem disease of unknown etiology characterized by chronic destructive synovitis. It's prevalence is about 1% all over the world. Serologic markers are also important beside some clinical situations upon RA diagnosis. Today, the most commonly used laboratory test is rheumatoid factor (RF) in patients with suspected RA. RF is sensitive but not a specific biomarker for diagnosing RA. Early diagnosis of RA is essential to prevent of progressive joint damage. In recent years, anticyclic citrullinated peptide/protein antibody (anti-CCP) attracts the attention as a remarkable biomarker for early diagnosis. Anti-CCP which is a family of anti-citrullinated protein antibodies (ACPA) family, showed quite satisfactory specificity in the diagnosis of RA. Due to the prescence of ACPA was included to 2010 RA diagnostic criteria, in a manner of speaking, importance of anti-CCP was registered

Özet

Romatoid artrit (RA); etyolojisi belli olmayan, kronik eroziv sinovit ile karakterize, inflamatuvar multisistemik bir hastalıktır. Dünya genelinde prevelansı %1 civarındadır. RA tanısında bir takım klinik durumlar ile beraber serolojik belirteçlerin de önemi büyüktür. Günümüzde RA şüphesi olan hastalarda en yaygın kullanılan laboratuvar testi romatoid faktör (RF)'dür. RF, RA tanısında duyarlı ancak özgül olmayan bir parametredir. RA'nın erken tanısı, ilerleyici eklem hasarının önüne geçilebilmesi açısından önemli yer teşkil etmektedir. Antisiklik sitrulin peptid/protein (anti-CCP) son yıllarda erken tanı amacıyla kullanılan dikkate değer bir belirteç olarak göze çarpmaktadır. Sitrüllinlenmiş peptid/protein antikorları (ACPA) ailesinin en önemli üyesi olan anti-CCP, RA tanısında oldukça tatmin edici özgüllük değerleri göstermiştir. ACPA varlığının 2010 RA tanı kriterlerine dâhil edilmesiyle anti-CCP'nin önemi bir anlamda tescillenmiştir

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Cite This Article

AĞILLI, M., EKİNCİ, Ş., AYDIN, F. N., ŞENER, İ., PARLAK, A., YAMAN, H. (2014). Anti-cyclic Citrullinated Peptide Antibody (Anti-CCP) and Diagnostic Value for Rheumatoid Arthritis. TSK Koruyucu Hekimlik Bülteni, Cilt: 13 - Sayı: 1, 83–88. https://ajindex.com/articles/126044

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