Journals / Bakırköy Tıp Dergisi / 2019 / Cilt: 15 - Sayı: 2

A Link Between Pregnancy Outcomes and Anticardiolipin Antibody in Subjects with Abortus İmminens

Abortus İmminens Tanılı Olgularda Antikardiyolipin Antikor Pozitifliği ile Gebelik Sonuçları Arasındaki İlişki

Pages
136–141
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: The circulating anti-cardiolipin antibody levels were found to be elevated in women with abortus imminens having subchorionic hematoma compared to those women with abortus imminens not having subchorionic hematoma and there was a relationship between anti-cardiolipin antibody and unfavorable pregnancy outcome.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Abortus imminens is a critical complication observed 10-20% of all pregnant women.
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Key Findings & Data:Methods: The study has been planned as a case-controlled one, in which 41 women with abortus imminens and subchorionic hematoma; and 29 women with abortus imminens and without subchorionic hematoma were included and where the demographic data of those women were defined.
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Conclusion & Impact:Conclusion: The circulating anti-cardiolipin antibody levels were found to be elevated in women with abortus imminens having subchorionic hematoma compared to those women with abortus imminens not having subchorionic hematoma and there was a relationship between anti-cardiolipin antibody and unfavorable pregnancy outcome.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Abortus imminens is a critical complication observed 10-20% of all pregnant women. Subchorionic hematoma is an important parameter in the diagnosis of abortus imminens; however, it is yet to be known the exact cause of subchorionic hematoma. A relation is thought to exist between anti-cardiolipin antibodies and subchorionic hematoma. So, we hereby in this study have compared the positiveness of the anti-cardiolipin antibodies in women with and without subchorionic hematoma. We have as well examined whether there is a relation between pregnancy outcomes and anti-cardiolipin positiveness. Methods: The study has been planned as a case-controlled one, in which 41 women with abortus imminens and subchorionic hematoma; and 29 women with abortus imminens and without subchorionic hematoma were included and where the demographic data of those women were defined. The level of anti-cardiolipin antibodies (IgG, IgM) was measured by ELISA method. Results: No substantive difference has been detected between women with abortus imminens having subchorionic hematoma; and women with abortus imminens not having subchorionic hematoma in terms of age, parity and gravity. Compared to the women without subchorionic hematoma, the anti-cardiolipin antibody positiveness has been observed to be higher in the women with subchorionic hematoma in statistical terms. Furthermore, unfavorable pregnancy outcomes have been seen at a higher rate in pregnant women with positive anti-cardiolipin antibody compared to the nonpositive ones in the study. Conclusion: The circulating anti-cardiolipin antibody levels were found to be elevated in women with abortus imminens having subchorionic hematoma compared to those women with abortus imminens not having subchorionic hematoma and there was a relationship between anti-cardiolipin antibody and unfavorable pregnancy outcome.

Özet

Amaç: Düşük tehdidi (abortus imminens) tüm gebelerin %10-20’sinde görülebilen önemli bir komplikasyondur. Subkoryonik hematom abortus imminensin prognozunda önemli bir parametredir ancak subkoryonik hematomun neden oluştuğu tam olarak bilinmemektedir. Anti-kardiyolipin antikorları ile subkoryonik hematom arasında ilişki olduğu düşünülmektedir. Bu nedenle bizde araştırmamızda subkoryonik hematomu olan ve olmayan abortus imminensli kadınlarda anti-kardiyolipin antikorlarının pozitifliğini karşılaştırdık. Ayrıca doğum sonuçları ile antikardiolipin pozitifliği arasında bir ilişki olup olmadığını inceledik. Yöntemler: Araştırmamız olgu-kontrollü bir araştırma olarak planlandı. Araştırmaya 41 subkoryonik hematomu olan kadın ve 29 subkoryonik hematomu olmayan abortus imminensli kadın dahil edildi. Araştırmaya dahil edilen kadınların demografik verileri tanımlandı. Anti-kardiyolipin antikorlarının (IgG, IgM) düzeyi ELISA yöntemi ile ölçüldü. Bulgular: Subkoryonik hematomu olan abortus imminensi kadınlar ile subkoryonik hematomu olmayan abortus imminensli kadınlar arasında yaş, parite ve gravite açısından anlamlı bir fark saptanmadı. Subkoryonik hematomu olan kadınlarda anti-kardiyolipin antikor pozitifliği subkoryonik hematomu olmayan kadınlara göre istatistiksel olarak anlamlı daha yüksek saptandı. Ayrıca araştırmamızda anti-kardiyolipin antikor pozitif olan gebelerde anti-kardiyolipin pozitif olmayan gebelere göre olumsuz gebelik sonuçları daha sık görüldü. Sonuç: Subkoryonik hematomu olan kadınlarda abortus imminensli subkoryonik hematomu olmayan abortus imminensli kadınlara göre anti-kardiyolipin pozitifliği daha sık görülmektedir ve antikardiyolipin antikor pozitifliği ile olumsuz gebelik sonuçları arasında bir ilişki vardır.

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Cite This Article

ALAN, Y., ALAN, M., GÜRLEK, B., KURBAN, Y., UYAR, İ., AKPAK, Y. K., DANIŞMAN, A. N. (2019). A Link Between Pregnancy Outcomes and Anticardiolipin Antibody in Subjects with Abortus İmminens. Bakırköy Tıp Dergisi, Cilt: 15 - Sayı: 2, 136–141. https://ajindex.com/articles/125708

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