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Journals / Kocatepe Tıp Dergisi / 2026 / Cilt: 26 Sayı: 1

EFFECT OF SYSTEMIC IMMUNE-INFLAMMATION INDEX ON MORTALITY IN PATIENTS WITH PERIPHERAL ARTERY DISEASE

PERİFERİK ARTER HASTALIĞI OLAN HASTALARDA SİSTEMİK İMMÜN-ENFLAMASYON İNDEKSİNİN MORTALİTE ÜZERİNE ETKİSİ

İbrahim Etem Dural(Afyonkarahisar Sağlık Bilimleri Üniversitesi)0000-0003-4005-4858
Zafer Yalım(Afyonkarahisar Sağlık Bilimleri Üniversitesi)0000-0001-7736-0205
Uğur Aksu(Afyonkarahisar Sağlık Bilimleri Üniversitesi)0000-0003-0918-5032
Mehmet Özgeyik(ESKİŞEHİR ŞEHİR HASTANESİ)0000-0002-8510-3505
Serkan Gökaslan(Afyonkarahisar Sağlık Bilimleri Üniversitesi)0000-0001-7268-178X
Ömer Faruk Yılmaz(Afyonkarahisar Sağlık Bilimleri Üniversitesi)0000-0002-0055-8341
Pages
28–32
Publication Date
2025-01-27
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⚡ TL;DR(Too Long; Didn't Read)

CONCLUSIONS: In conclusion, the systemic immune-inflammation index is a significant determinant of survival in patients with peripheral artery disease.

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTIVE: Peripheral artery disease ranks as the third leading cause of death and illness following coronary artery disease and cerebrovascular disease among atherosclerotic conditions, representing a significant health concern worldwide.
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Key Findings & Data:MATERIAL AND METHODS: In this retrospective cohort study, we examined the medical records of 432 individuals diagnosed with peripheral artery disease between the years 2010 and 2020.
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Conclusion & Impact:CONCLUSIONS: In conclusion, the systemic immune-inflammation index is a significant determinant of survival in patients with peripheral artery disease.
🔬Design:Araştırma Makalesi
📍Scope:2010 Verileri
⚙️Variables:Periferik arter hastalığı · Sistemik immün- inflamasyon indeks · Ölüm oranı

Abstract

OBJECTIVE: Peripheral artery disease ranks as the third leading cause of death and illness following coronary artery disease and cerebrovascular disease among atherosclerotic conditions, representing a significant health concern worldwide. Our study aims to explore the association between the systemic immune- inflammation index a combined marker of inflammation and aggregation and survival in patients with peripheral artery disease. MATERIAL AND METHODS: In this retrospective cohort study, we examined the medical records of 432 individuals diagnosed with peripheral artery disease between the years 2010 and 2020. The systemic immune-inflammation index was calculated based on platelet to lymphocyte ratios from the patients’ complete blood count tests, and the relationship between this index and mortality was assessed using the Kaplan-Meier survival analysis. RESULTS: Our findings demonstrate that the systemic immune- inflammation index is an independent predictor of mortality in peripheral artery disease. Statistical analyses have shown that higher values of the systemic immune-inflammation index (> 854), correlate with increased mortality in individuals with peripheral artery disease and type two diabetes mellitus (OR: 1.02, %95 GA: 0.98-1.04, p<0.001). CONCLUSIONS: In conclusion, the systemic immune-inflammation index is a significant determinant of survival in patients with peripheral artery disease. These results can enhance our understanding of the role of inflammation and immune response in the management of peripheral artery disease and may contribute to developing potential therapeutic strategies.

Özet

AMAÇ: Aterosklerotik hastalıklar arasında koroner arter hastalığı ve serebrovasküler hastalıktan sonra üçüncü sıradaki mortalite ve morbidite nedeni olan periferik arter hastalığı, dünya genelinde önemli bir sağlık sorunudur. Çalışmamız, inflamasyon ve agregasyonun birleşik bir belirteci olan sistemik immün-inflamasyon indeksi ile periferik arter hastalığı olan hastalarda sağkalım arasındaki ilişkiyi araştırmayı amaçlamaktadır. GEREÇ VE YÖNTEM: Bu retrospektif kohort çalışmasında, 2010- 2020 yılları arasında periferik arter hastalığı tanısı konmuş 432 bireyin hasta kayıtları incelenmiştir. Hastaların hemogram testlerindeki trombosit-lenfosit oranlarından yola çıkarak sistemik immün-inflamasyon indeksi hesaplanmış ve bu indeks ile mortalite arasındaki ilişki Kaplan Meier analizi ile değerlendirilmiştir. BULGULAR: Çalışma bulgularımız, sistemik immün-inflamasyon indeksinin periferik arter hastalığında mortalitenin bağımsız bir belirleyicisi olduğunu ortaya koymuştur. İstatistiksel analizler, yüksek sistemik immün-inflamasyon indeksi değerlerinin (> 854), periferik arter hastalığı ve tip 2 diyabet mellituslu bireylerde artmış mortalite ile ilişkili olduğunu göstermiştir (OR: 1.02, %95 GA: 0.98-1.04, p<0.001). SONUÇ: Sonuç olarak, sistemik immün-inflamasyon indeksi, periferik arter hastalığı olan hastalarda sağkalımı öngördüren önemli bir faktördür. Bu bulgular, periferik arter hastalığı yönetiminde inflamasyon ve immün yanıtın rolünü daha iyi anlamamıza yardımcı olabilir ve potansiyel tedavi stratejilerinin geliştirilmesine katkı sağlayabilir.

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Cite This Article

Dural, İ. E., Yalım, Z., Aksu, U., Özgeyik, M., Gökaslan, S., Yılmaz, Ö. F. (2025). EFFECT OF SYSTEMIC IMMUNE-INFLAMMATION INDEX ON MORTALITY IN PATIENTS WITH PERIPHERAL ARTERY DISEASE. Kocatepe Tıp Dergisi, Cilt: 26 Sayı: 1, 28–32. https://doi.org/10.18229/kocatepetip.1442806

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