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Journals / Kocatepe Tıp Dergisi / 2026 / Cilt: 26 Sayı: 2

EVALUATION OF INFLAMMATORY HEMATOLOGICAL PARAMETERS IN PREGNANCIES COMPLICATED WITH INTRAUTERINE GROWTH RESTRICTION

İNTRAUTERİN GELİŞME GERİLİĞİ İLE KOMPLİKE OLAN GEBELİKLERDE İNFLAMATUAR HEMATOLOJIK PARAMETRELERIN DEĞERLENDİRİLMESİ

Hasan Eroglu(Afyonkarahisar Sağlık Bilimleri Üniversitesi)0000-0002-1180-5299
Şeref Utku Çakır(AFYON KOCATEPE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0009-0007-2776-2178
Fidansu Erdoğan(AFYON KOCATEPE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0009-0002-7179-7873
Bayram Ali Ekin(AFYON KOCATEPE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0009-0008-9926-6314
Enes Eren Şenel(AFYON KOCATEPE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0009-0003-0201-6356
Berke Kaya(AFYON KOCATEPE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0009-0006-1947-876X
Neslihan Sare Nazlı(AFYON KOCATEPE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0009-0005-1437-5166
Kadiralp Özdemir(AFYON KOCATEPE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0009-0003-2742-5068
Atiye Sedef Dilek(AFYON KOCATEPE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0009-0009-0209-6433
Kadir Kaan Selçuk(AFYON KOCATEPE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0009-0000-8854-9150
Melisa Tekirtaş(AFYON KOCATEPE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0009-0002-0433-7172
Pages
108–112
Publication Date
2025-04-28
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Further research is needed to determine the importance of inflammatory hematological indices in IUGR patients.

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTIVE: To evaluate the usability of inflammatory hematological parameters in Intrauterine Growth Retardation (IUGR) patients.
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Key Findings & Data:MATERIAL AND METHODS: This case-control study included 200 pregnant women divided into IUGR (n=100) and control (n=100) groups.
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Conclusion & Impact:Further research is needed to determine the importance of inflammatory hematological indices in IUGR patients.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Gebelik · Intrauterine Gelişme Geriliği · Nötrofil/lenfosit oranı (NLR) trombosit/lenfosit oranı (PLR)

Abstract

OBJECTIVE: To evaluate the usability of inflammatory hematological parameters in Intrauterine Growth Retardation (IUGR) patients. MATERIAL AND METHODS: This case-control study included 200 pregnant women divided into IUGR (n=100) and control (n=100) groups. Laboratory parameters such as neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) of these pregnant women at the time of admission to the hospital for delivery were evaluated retrospectively. Intrauterine Growth Retardation was defined as the estimated fetal weight of the fetus below the 10th percentile for gestational age. RESULTS: Mean PLR levels were found to be statistically significantly higher in women who developed Intrauterine Growth Retardation (121.32±44.80 vs 117.62±44.64, p = 0.014). PLR accurately predicted the occurrence of IUGR with 55% sensitivity and specificity rates at a cut-off level of 107.48 (AUC = 0.53 (95% confidence interval 0.451–0.610). CONCLUSIONS: PLR level can be used as a potential marker to predict the development of Intrauterine Growth Retardation in pregnant women. The usefulness of PLR level as a potential marker to predict the development of IUGR in pregnant women is limited due to relatively low sensitivity and specificity. Further research is needed to determine the importance of inflammatory hematological indices in IUGR patients.

Özet

AMAÇ: Intrauterine Gelişme Geriliği (IUGR) bulunan hastalarda inflamatuar hematolojik parametrelerin kullanılabilirliğini değerlendirmek. GEREÇ VE YÖNTEM: Bu vaka-kontrol çalışmasına sırasıyla IUGR (n=100) ve kontrol (n=100) gruplarına ayrılan 200 gebe dahil edildi. Bu gebelerin, doğum için hastaneye başvuru sırasındaki nötrofil/lenfosit oranı (NLR) ve trombosit/lenfosit oranı (PLR) gibi laboratuvar parametreleri retrospektif olarak değerlendirildi. Intrauterine Gelişme Geriliği, gebelik haftasına göre fetüsün tahmini fetal ağırlığının 10.persantilin altında olması olarak tanımlandı. BULGULAR: Ortalama PLR düzeyleri, Intrauterine Gelişme Geriliği gelişen kadınlarda istatistiksel olarak anlamlı şekilde daha yüksek bulundu (121, 32±44, 80’e karşı 117, 62±44, 64, p=0.014). PLR 107,48 cutt-of düzeyinde, IUGR oluşumunu %55 duyarlılık ve özgüllük oranlarıyla doğru bir şekilde tahmin etti (AUC = 0,53 (%95 güven aralığı 0.451–0.610). SONUÇ: Son çalışmalar Intrauterine Gelişme Geriliği etiyolojisinde inflamasyonun da rol oynayabileceğini göstermiştir. Gebelerde IUGR gelişimini predikte etmek için, potansiyel bir belirteç olarak PLR düzeyinin faydası, nispeten düşük duyarlılık ve özgüllük nedeniyle sınırlıdır. IUGR hastalarında, inflamatuar hematolojik indekslerin önemini belirlemek için daha fazla araştırmaya ihtiyaç vardır.

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Cite This Article

Eroglu, H., Çakır, Ş. U., Erdoğan, F., Ekin, B. A., Şenel, E. E., Kaya, B., Nazlı, N. S., Özdemir, K., Dilek, A. S., Selçuk, K. K., Tekirtaş, M. (2025). EVALUATION OF INFLAMMATORY HEMATOLOGICAL PARAMETERS IN PREGNANCIES COMPLICATED WITH INTRAUTERINE GROWTH RESTRICTION. Kocatepe Tıp Dergisi, Cilt: 26 Sayı: 2, 108–112. https://doi.org/10.18229/kocatepetip.1458019

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