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Journals / Kocatepe Tıp Dergisi / 2026 / Cilt: 27 Sayı: 2

THE EARLY EFFECTS OF LONG BONE FRACTURES ON ENDOTHELIAL FUNCTION; A PROSPECTIVE CLINICAL STUDY USING THE FLOW-MEDIATED DILATATION METHOD

UZUN KEMİK KIRIĞININ ENDOTEL FONKSİYONUNA ERKEN ETKİLERİ; AKIM ARACILI DİLATASYON YÖNTEMİNİ KULLANAN PROSPEKTİF KLİNİK ÇALIŞMA

Mehmet Ali Dursun(tavşanlı devlet hastanesi)0000-0003-2679-9351
Ali Aydın(ATATÜRK ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-6964-4363
Pages
252–257
Publication Date
2026-04-16
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It should be kept in mind that endothelial dysfunction may be involved in the pathogenesis of systemic complications in the acute period after long bone fracture.

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTIVE: Vascular endothelial function can be affected by inflammatory processes..
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Key Findings & Data:MATERIAL AND METHODS: We prospectively researched 44 patients aged 18-60 with long bone fractures and no other disease between 2018 and 2020.
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Conclusion & Impact:It should be kept in mind that endothelial dysfunction may be involved in the pathogenesis of systemic complications in the acute period after long bone fracture.
🔬Design:Araştırma Makalesi
📍Scope:2018 Verileri
⚙️Variables:Endotel disfonksiyonu · Akım aracılı dilatasyon · Uzun kemik kırığı.

Abstract

OBJECTIVE: Vascular endothelial function can be affected by inflammatory processes.. Tissue damage in long bone fractures can cause a robust inflammatory response. We aimed to evaluate the effect of this inflammatory response caused by long bone fractures on endothelial functions in the early period. MATERIAL AND METHODS: We prospectively researched 44 patients aged 18-60 with long bone fractures and no other disease between 2018 and 2020. We evaluated vascular endothelial function using the flow-mediated dilatation (FMD) method. Measurements obtained at the beginning of the acute fracture period and at the first month were recorded as FMD-0 and FMD-1, respectively. RESULTS: The mean FMD-0 values were measured as 0.082±0.046 (range: 0.005-0.18). Mean FMD-1 values were measured as 0.118 ± 0.054 (range: 0.03-0.24). The mean FMD values of the patients were significantly higher in the first month (p=0.02). No significant relationship was found between other parameters such as age, gender, side, limb difference (upper, lower), and FMD results (p>0.05 for all values). CONCLUSIONS: Severe inflammation caused by long bone fractures may lead to endothelial dysfunction in the acute period.. It should be kept in mind that endothelial dysfunction may be involved in the pathogenesis of systemic complications in the acute period after long bone fracture.

Özet

AMAÇ: Vasküler endotel fonksiyonları inflamatuar süreçlerden etkilenebilir. Uzun kemik kırıklarındaki doku hasarı güçlü bir inflamatuar yanıta neden olabilir. Uzun kemik kırıklarının neden olduğu bu inflamatuar yanıtın erken dönemde endotel fonksiyonları üzerindeki etkisini değerlendirmeyi amaçladık. GEREÇ VE YÖNTEM: 2018-2020 yılları arasında uzun kemik kırığı olan ve başka bir hastalığı olmayan 18-60 yaş arası 44 hasta prospektif olarak araştırıldı. Hastaların vasküler endotel fonksiyonlarını akım aracılı dilatasyon yöntemi (FMD) ile değerlendirdik. Akut kırık döneminde inflamatuar sürecin başlangıcında ve inflamasyonun minimal olduğu birinci ayda yapılan ölçümlerin verileri sırasıyla FMD-0 ve FMD-1 olarak kaydedildi. BULGULAR: Ortalama FMD-0 değerleri 0,082±0,046 (aralığı: 0,005-0,18) olarak ölçüldü. Ortalama FMD-1 değerleri 0,118 ± 0,054 (aralığı: 0,03-0,24) olarak ölçüldü. Hastaların ortalama FMD değerleri birinci ayda anlamlı olarak daha yüksekti (p=0,02). Yaş, cinsiyet, taraf, ekstremite farkı (üst, alt) ile FMD sonuçları gibi diğer parametreler arasında anlamlı bir ilişki yoktu (hepsi için p>0,05). SONUÇ: Uzun kemik kırıklarının neden olduğu şiddetli inflamasyon, akut dönemde endotel disfonksiyonuna neden olabilir. Uzun kemik kırığı sonrası görülen sistemik komplikasyonların patogenezinde endotel disfonksiyonunun rol oynayabileceği akılda tutulmalıdır.

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Cite This Article

Dursun, M. A., Aydın, A. (2026). THE EARLY EFFECTS OF LONG BONE FRACTURES ON ENDOTHELIAL FUNCTION; A PROSPECTIVE CLINICAL STUDY USING THE FLOW-MEDIATED DILATATION METHOD. Kocatepe Tıp Dergisi, Cilt: 27 Sayı: 2, 252–257. https://doi.org/10.18229/kocatepetip.1717575

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