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Journals / Kocatepe Tıp Dergisi / 2026 / Cilt: 27 Sayı: 3

7,8 DHF, A TRKB AGONIST, AMELIORATES CORTICAL IMPAIRMENT INDUCED BY A CAFETERIA DIET

7,8 DHF, BİR TRKB AGONİSTİ, KAFETERYA DİYETİ TARAFINDAN İNDÜKLENEN KORTİKAL BOZULMAYI İYİLEŞTİRİR

Hatice Keser(Afyonkarahisar Sağlık Bilimleri Üniversitesi)0000-0002-0990-2612
Elif Şahin(KARADENİZ TEKNİK ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-5864-9548
Ahmet Alver(KARADENİZ TEKNİK ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-9617-6689
İsmail Abidin(KARADENİZ TEKNİK ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0003-2510-9718
Pages
348–356
Publication Date
2026-07-20
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Biochemical data were evaluated for oxida-tive stress analysis.RESULTS: Behavioral test results showed that the 7,8-DHF group performed better in the hang wire test compared to the Caf group.

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTIVE: The aim of this study is to investigate the relations-hip between cafeteria diet and its negative effects on the brain and the effects of 7,8-Dihydroxyflavone (7,8-DHF), a tropom-yosin receptor kinase B (TrkB) agonist, in ameliorating cortical impairment induced by this diet.
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Key Findings & Data:MATERIAL AND METHODS: The study was conducted with 40 C57BL/6 mice obtained from Karadeniz Technical University.
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Conclusion & Impact:Biochemical data were evaluated for oxida-tive stress analysis.RESULTS: Behavioral test results showed that the 7,8-DHF group performed better in the hang wire test compared to the Caf group.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Kafeterya diyeti · 8-DHF · Korteks

Abstract

OBJECTIVE: The aim of this study is to investigate the relations-hip between cafeteria diet and its negative effects on the brain and the effects of 7,8-Dihydroxyflavone (7,8-DHF), a tropom-yosin receptor kinase B (TrkB) agonist, in ameliorating cortical impairment induced by this diet. MATERIAL AND METHODS: The study was conducted with 40 C57BL/6 mice obtained from Karadeniz Technical University. The mice were divided into four groups (n=9-11): Control, cafe-teria diet (Caf), cafeteria diet with vehicle (Sham), and cafeteria diet with 7,8-Dihydroxyflavone (7,8-DHF). The Control group of mice received a control diet, while the other groups were fed a cafeteria diet for 16 weeks. During the last 28 days, 5 mg/kg of 7,8 DHF was administered to the 7,8-DHF group, while the sham group received a vehicle solution. After the experimental period, behavioral tests (cylinder test, hang wire test, adhesive removal test) were performed and the mice were decapitated for tissue sampling. Biochemical data were evaluated for oxida-tive stress analysis.RESULTS: Behavioral test results showed that the 7,8-DHF group performed better in the hang wire test compared to the Caf group. In biochemical analyses, it was observed that 7,8-DHF significantly reduced malondialdehyde (MDA) levels in both the hippocampus and cortex tissues. The total antioxidant levels complemented the reduction in MDA levels.CONCLUSIONS: 7,8-DHF has ameliorated the cortical functions by reducing oxidative stress induced by the cafeteria diet. This study suggests that this small molecule could provide protecti-ve effects against the negative consequences arising from cafe-teria diet habits.

Özet

AMAÇ: Bu çalışmanın amacı, kafeterya diyetinin beyin üzerindeki olumsuz etkileri ile bu diyetin oluşturduğu kortikal bozukluğun iyileştirilmesinde bir tropomiyozin reseptör kinaz B (TrkB) agonisti olan 7,8-Dihidroksiflavon (7,8-DHF) arasındaki ilişkiyi araştırmaktır. GEREÇ VE YÖNTEM: Çalışma, Karadeniz Teknik Üniversitesi'nden temin edilen 40 C57BL/6 fare ile gerçekleştirildi. Fareler dört gruba (n=9-11) ayrıldı: Kontrol, kafeterya diyet (Caf), çözücü ile birlikte kafeterya diyet (Sham) ve 7,8-Dihidroksiflavon (7,8-DHF) ile kafeterya diyet. Kontrol grubu fareler kontrol diyeti alırken, diğer gruplara 16 hafta boyunca kafeterya diyeti verildi. Son 28 gün boyunca, 7,8-DHF grubuna 5 mg/kg 7,8 DHF uygulanırken, sham grubuna çözücü verildi. Sonra, davranış testleri (silindir testi, telde asılı kalma testi, yapışkan çıkarma testi) yapıldı ve fareler doku örneklemesi için dekapite edildi. Biyokimyasal veriler oksidatif stres analizi için değerlendirildi. BULGULAR: Yapılan davranış testleri sonucunda, 7,8-DHF grubunun telde asılı kalma testinde Caf gruba göre daha iyi performans gösterdiği kaydedildi. Biyokimyasal analizlerde, 7,8-DHF'nin hem hipokampüs hem de korteks dokularındaki malondialdehit (MDA) seviyelerini önemli ölçüde azalttığı görüldü. Toplam antioksidan seviyeleri, MDA seviyelerindeki azalmayı tamamladı. SONUÇ: 7,8-DHF, kafeterya diyeti ile indüklenen oksidatif stresi azaltarak kortikal fonksiyonları iyileştirmiştir. Bu çalışma, bu küçük molekülün kafeterya diyeti alışkanlıklarından kaynaklanan olumsuz sonuçlara karşı koruyucu etkiler sağlayabileceğini öne sürmektedir.

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Cite This Article

Keser, H., Şahin, E., Alver, A., Abidin, İ. (2026). 7,8 DHF, A TRKB AGONIST, AMELIORATES CORTICAL IMPAIRMENT INDUCED BY A CAFETERIA DIET. Kocatepe Tıp Dergisi, Cilt: 27 Sayı: 3, 348–356. https://doi.org/10.18229/kocatepetip.1734434

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