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Journals / Çocuk Dergisi / 2026 / Cilt: 24 Sayı: 1

Pregnancy in Patients with Thalassemia: A Single-Center Study

Selime Aydoğdu(University of Health Sciences, Umraniye Training and Research Hospital, Pediatric Hematology and Oncology Clinic)0000-0003-3380-3080
Begum Sirin Koc(University of Health Sciences, Umraniye Training and Research Hospital, Pediatric Hematology and Oncology Clinic)0000-0002-6127-3147
Şifa Şahin(Istanbul University Medical Faculty, Department of Child Health and Diseases. Department of Pediatric Hematology and Oncology)0000-0001-7402-8944
Simge Erdem(Istanbul University Medical Faculty, Department of Internal Medicine, Department of Hematology)0000-0001-8095-5445
Serap Karaman(Istanbul University Medical Faculty, Department of Child Health and Diseases. Department of Pediatric Hematology and Oncology)0000-0002-7428-3897
Zeynep Karakaş(Istanbul University Medical Faculty, Department of Child Health and Diseases. Department of Pediatric Hematology and Oncology)0000-0002-8835-3235
Pages
25–29
Publication Date
2024-05-07
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusions: Thalassemia patients who are followed up with a regular multidisciplinary approach will be able to have a healthy pregnancy and children through the early recognition, prevention and treatment of complications.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: In thalassemia syndromes, iron accumulation due to transfusion or excessive iron absorption adversely affects many organ functions, including the endocrine system.
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Key Findings & Data:Due to advances in effective transfusion and chelation therapy in recent years a significant increase as occured in the life expectancy and quality of life of patients.
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Conclusion & Impact:Conclusions: Thalassemia patients who are followed up with a regular multidisciplinary approach will be able to have a healthy pregnancy and children through the early recognition, prevention and treatment of complications.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Thalassemia · pregnancy · child

Abstract

Objective: In thalassemia syndromes, iron accumulation due to transfusion or excessive iron absorption adversely affects many organ functions, including the endocrine system. Due to advances in effective transfusion and chelation therapy in recent years a significant increase as occured in the life expectancy and quality of life of patients. This situation has also led to an increase in patients’ expectation of having children. Methods: This study retrospectively, evaluates the transfusion characteristics, complications and conditions of the babies with regard to pre-pregnancy, pregnancy and delivery of our transfusion-dependent thalassemia patients who’ve had children and were monitored at the Istanbul University Medical Faculty, Department of Pediatric Hematology and Oncology. Results: The study includes 15 patients with a gestational age between 22-34 (28±3,9) years, five with thalassemia major, nine with thalassemia intermedia, and one with thalassemia trait and alpha triplication. While 14 patients came for regular follow-ups, one did not. The patients on a regular transfusion program had an increased frequency of transfusions throughout pregnancy; four patients with thalassemia intermedia, who had never undergone a transfusion before, were observed to have been included in a regular transfusion program starting with the 2nd trimester of pregnancy. None of the patients developed cardiac and/or thromboembolic complications. One patient diagnosed with thalassemia intermedia and one patient diagnosed with thalassemia major each had a stillborn baby, three patients diagnosed with thalassemia intermedia had preterm babies and four other patients had babies with intrauterine growth restrictions (IUGR). Conclusions: Thalassemia patients who are followed up with a regular multidisciplinary approach will be able to have a healthy pregnancy and children through the early recognition, prevention and treatment of complications.

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Cite This Article

Aydoğdu, S., Koc, B. S., Şahin, Ş., Erdem, S., Karaman, S., Karakaş, Z. (2024). Pregnancy in Patients with Thalassemia: A Single-Center Study. Çocuk Dergisi, Cilt: 24 Sayı: 1, 25–29. https://doi.org/10.26650/jchild.2024.1352861

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