SavedAdd your journal

Journals / Çocuk Dergisi / 2026 / Cilt: 25 Sayı: 3

Factor XII Levels in the Newborns of Mothers with Gestational Diabetes: A Cohort Study

Şükran Yıldırım(University of Health Sciences, Prof. Dr. Cemil Tascıoglu City Hospital, Clinic of Neonatology)0000-0002-9678-1571
Atalay Demirel(Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Division of Neonatology, Department of Pediatrics)0000-0001-6583-512X
Pages
132–135
Publication Date
2025-10-31
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These findings could inspire future research in this area, potentially leading to the development of new strategies for managing neonatal health in the context of GDM.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: This study aimed to investigate the impact of gestational diabetes mellitus (GDM) on the activity and antigen levels of Factor XII (FXII) in neonates.
📊
Key Findings & Data:Results: The FXII activity in the GDM group was slightly higher (45.52 ± 18.19%) compared with the control group (43.46 ± 14.63%); however, this difference was not statistically significant (p = 0.534).
💡
Conclusion & Impact:These findings could inspire future research in this area, potentially leading to the development of new strategies for managing neonatal health in the context of GDM.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Factor XII · newborn · coagulation

Abstract

Objective: This study aimed to investigate the impact of gestational diabetes mellitus (GDM) on the activity and antigen levels of Factor XII (FXII) in neonates. Factor XII, a coagulation factor, is known to play a role in thrombosis and inflammation, and its levels can be influenced by various health conditions, including GDM. Materials and Methods: We analyzed umbilical cord blood samples from neonates born to mothers with gestational diabetes mellitus (GDM) and from mothers without GDM as a control group. The infants in the GDM group were born to mothers diagnosed with GDM using the Carpenter-Coustan criteria, whereas the control group included infants born to mothers without GDM or any other pregnancy complications. The samples were examined for levels and activity of the FXII antigen. Results: The FXII activity in the GDM group was slightly higher (45.52 ± 18.19%) compared with the control group (43.46 ± 14.63%); however, this difference was not statistically significant (p = 0.534). In contrast, FXII antigen levels were higher in the control group (70.19 ± 48.73 ng/mL) than in the GDM group (64.44 ± 51.87 ng/mL), but this difference was also not statistically significant (p = 0.166). Additionally, a significant positive correlation was observed between FXII activity and gestational age in the GDM group (r = 0.509, p = 0.005). Conclusion: While no significant differences were found in FXII levels between the two groups, the significant correlation between FXII activity and gestational age in the GDM group suggests a potential role of FXII in thrombosis and inflammation in infants born to mothers with GDM. These findings could inspire future research in this area, potentially leading to the development of new strategies for managing neonatal health in the context of GDM.

🔖

Cite This Article

Yıldırım, Ş., Demirel, A. (2025). Factor XII Levels in the Newborns of Mothers with Gestational Diabetes: A Cohort Study. Çocuk Dergisi, Cilt: 25 Sayı: 3, 132–135. https://doi.org/10.26650/jchild.2025.1719801

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (22)

  1. Behboudl-Gandevanl S, Amlrl M, Bldhendl Yarandl R, Ramezanl Tehranl F. The lmpact of dlagnostlc crlterla for gestatlonal dlabetes on lts prevalence: a sYstematlc revlew and meta-analYsls. Diabetol Metab Syndr. 2019;11:11. Publlshed 2019 Feb 1. dol:10.1186/s13098-019-0406-1 google scholar
  2. Paulo MS, Abdo NM, Bettencourt-Sllva R, Al-Rlfal RH. Gestatlonal Dlabetes Mellltus ln Europe: A SYstematlc Revlew and Meta-AnalYsls of Prevalence Studles. Front Endocrinol (Lausanne). 2021;12:691033. Publlshed 2021 Dec 9. dol:10.3389/fendo.2021.691033 google scholar
  3. Wlcklow B, Retnakaran R. Gestatlonal Dlabetes Mellltus and İts İmpllcatlons across the Llfe Span. Diabetes Metab J. 2023;47(3):333-344. dol:10.4093/ dmj.2022.0348 google scholar
  4. Jensen LA, Chlk CL, RYan EA. Revlew of gestatlonal dlabetes mellltus effects on vascular structure and functlon. Diab Vasc Dis Res. 2016;13(3):170-182. dol:10.1177/1479164115624681 google scholar
  5. Khambule L, George JA. The Role of İnflammatlon ln the Development of GDM and the Use of Markers of İnflammatlon ln GDM Screenlng. Adv Exp Med Biol. 2019;1134:217-242. dol:10.1007/978-3-030-12668-1_12 google scholar
  6. Maas C, Renne T. Coagulatlon factor XII ln thrombosls and lnflammatlon. BlooD. 2018;131(17):1903-1909. dol:10.1182/blood-2017-04-569111 google scholar
  7. Chan NC, Weltz JI. New therapeutlc targets for the preventlon and treatment of venous thromboembollsm wlth a focus on factor XI lnhlbltors. Arterioscler Thromb Vasc Biol. 2023;43(10):1755-1763. dol:10.1161/ATVBAHA.123.318781 google scholar
  8. Maas C, Govers-Rlemslag JW, Bouma B et al. Mlsfolded protelns actlvate factor XII ln humans, leadlng to kalllkreln formatlon wlthout lnltlatlng coagulatlon. J Clin Invest. 2008;118(9):3208-3218. dol:10.1172/JCI35424 google scholar
  9. Matafonov A, Ivanov IS, Sun M, Gallanl D. Coagulatlon Factor XI and Factor XII ln DNA-Induced Thrombln Generatlon. Blood. 2014;124:581-581. dol: 10.1182/ Blood.V124.21.581.581 google scholar
  10. Kannemeler C, ShlbamlYa A, Nakazawa F et al. Extracellular RNA constltutes a natural procoagulant cofactor ln blood coagulatlon. Proc Natl Acad Sci U S A. 2007;104(15):6388-6393. dol:10.1073/pnas.0608647104 google scholar
  11. Trlplsclano C, Welss R, Karuthedom George S, Flscher MB, Weber V. Extracellular Veslcles Derlved From Platelets, Red Blood Cells, and MonocYte-Llke Cells Dlffer Regardlng Thelr AbllltY to Induce Factor XII-Dependent Thrombln Generatlon. Front Cell Dev Biol. 8:298, 2020. Publlshed 2020 MaY 5. dol:10.3389/ fcell.2020.00298 google scholar
  12. Nickel KF, Long AT, Fuchs TA, Butler LM, Renne T. Factor XII as a Therapeutlc Target ln Thromboembollc and InflammatorY Dlseases. Arterioscler Thromb Vasc Biol. 2017;37(1):13-20. dol:10.1161/ATVBAHA.116.308595 google scholar
  13. Taschereau-Charron A, Da Sllva MS, Bllodeau JF, Morlsset AS, Jullen P, Rudkowska I. Alteratlons of fattY acld profiles ln gestatlonal dlabetes and lnfluence of the dlet. Maturitas. 2017;99:98-104. dol:10.1016/ j.maturltas.2017.01.014. google scholar
  14. James-Allan LB, Devaskar SU. Extracellular veslcles and thelr role ln gestatlonal dlabetes mellltus. Placenta. 2021;113:15-22. dol:10.1016/j.placenta.2021.02.012 google scholar
  15. Ozbasll E, Takmaz O, Karabuk E, Gungor M. Comparlson of factor XII levels ln gestatlonal dlabetes, fetal macrosomla, and healthy pregnancles. BMC Pregnancy Childbirth. 2020;20(1):752. dol:10.1186/s12884-020-03455-0. google scholar
  16. Carpenter MW, Coustan DR. Crlterla for screenlng tests for gestatlonal dlabetes. Am J Obstet Gynecol. 1982;144:768-73. dol:10.1016/0002-9378(82)90349-0. google scholar
  17. Gorar S, Alloglu B, Ademoglu E et al. Is There a TendencY for Thrombosls ln Gestatlonal Dlabetes Mellltus? J Lab Physicians. 2016;8(2):101-105. dol:10.4103/0974-2727.180790. google scholar
  18. Pantham P, AYe IL, Powell TL. Inflammatlon ln maternal obesltY and gestatlonal dlabetes mellltus. Placenta. 2015;36(7):709-715. dol:10.1016/ j.placenta.2015.04.006 google scholar
  19. Kc K, Shakya S, Zhang H. Gestatlonal dlabetes mellltus and macrosomla: a llterature revlew. Ann Nutr Metab. 2015;66 Suppl 2:14-20. dol:10.1159/000371628. google scholar
  20. Hellgren M, Blomback M. Studles on blood coagulatlon and fibrlnolysls ln pregnancy, durlng delivery and ln the puerperlum. I. Normal condltlon. Gynecol Obstet Invest. 1981;12(3):141-154. dol:10.1159/000299596. google scholar
  21. Reverdlau-Moallc P, Delahousse B, Body G, Bardos P, Leroy J, Gruel Y. Evolutlon of blood coagulatlon actlvators and lnhlbltors ln the healthy human fetus. Blood. 1996;88(3):900-906. google scholar
  22. Andrew M., Paes B., Mllner R., Johnston M., Mltchell L., Tollefsen D.M., Powers P. Development of the human coagulatlon sYstem ln the full-term lnfant. Blood. 1987;70:165-172. dol: 10.1182/blood.V70.1.165.165. google scholar