AI Summary & Key Takeaways
AI InsightThe water soluble derivatives, A3G d , B 3 G d and C 3 G d obtained by deacylation of corresponding N-glucosides, were compared with A2 , B 2 , C 2 - All compounds were tested for their antiviral activity and it was found that they were highly active against poliomyelitis type-3 virus.
📌 3 Key Takeaways
Abstract
In this study, 5-thioeter derivatives; 1, 2, 4-triazole-5-thioacetic acid = A2 , 3-methyl-l, 2, 4-triazole-5-thioacetic acid = B 2 , 3-ethyl-l, 2, 4-triazole-5-thioacetic acid = C2 and their ethyl esters 1, 2, 4-triazole-5-thioacetic acid ethyl ester = A3 , 3-methyl-l, 2, 4-triazole-5- thioacetic acid ethyl ester = B 3 , 3-ethyl-l,2,4-triazole-5-thioacetic acid ethyl ester = C3 were prepared using 3-substitued-5-mercapto-l, 2, 4-triazoles synthesised previously. In order to investigate the effect of the ose molecule on activity, the compounds were converted to their nucleosides. The water soluble derivatives, A3G d , B 3 G d and C 3 G d obtained by deacylation of corresponding N-glucosides, were compared with A2 , B 2 , C 2 - All compounds were tested for their antiviral activity and it was found that they were highly active against poliomyelitis type-3 virus.
Özet
Bu çalışmada daha önce sentezleri gerçekleştirilen (1), 3-sübstitüe-5-merkapto-l, 2, 4-triazol'lerden hareketle 5-tiyoeter türevleri olan; 1, 2, 4-triazol-5-tiyoasetik asit = A2 , 3-metil-l, 2, 4-triazol-5- tiyoasetik asit = B 2 , 3-etil-l, 2, 4-triazol-5-tiyoasetik asit = C 2 , 1, 2, 4-triazol-5-tiyoasetikasit etil esteri= A3 , 3-metil-l, 2, 4-triazol-5-tiyoasetik asit etil esteri = B3 , 3-etil-l, 2, 4-triazol-5-tiyoasetik asit etil esteri = C 2 türevleri sentez edildi. Bu bileşiklerden A3 , B3 ve C2 türevlerinin antiviral etkileri karşılaştırılarak A2 , B 2 , C2 türevlerine ozun getireceği etkiyi incelemek ve suda çözünür hale dönüştürmek üzere glikozaminle nükleozitleri hazırlandı. Elde edilen nükleozitlerin deasetilasyonlarıyla A3G d , B 3 G d ve C 3 G d elde edildi. Daha sonra antiviral etkileri araştırıldı. RN A grubu viruslardan poliomielitis Tip-3 virusuna etkili oldukları görüldü.