Journals / Uludağ Üniversitesi Tıp Fakültesi Dergisi / 2026 / Cilt: 52

Evaluation of the Relationship Between Erectile Dysfunction and Pericardial and Epicardial Adipose Tissue Thickness

Erektil Disfonksiyon ile Perikardiyal ve Epikardiyal Adipoz Doku Kalınlığı Arasındaki İlişkinin Değerlendirilmesi

Sezgin Yeni(Mudanya University, Vocational School, Department of First and Emergency Aid, Bursa, Türkiye.)0000-0001-5143-6507
Mehmet Cem Başel(VM Medicalpark Bursa Hospital, Cardiology Department, Bursa, Türkiye.)0000-0002-5077-0527
Aydın Dursun(Mudanya University, Vocational School, Department of Anestesia, Bursa, Türkiye.)0000-0003-2792-7685
Yavuz Mert Aydın(Zonguldak Bülent Ecevit University, Faculty of Medicine, Department of Urology, Zonguldak, Türkiye.)0000-0002-6287-6767
Abdullah Gül(University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Department of Urology, Bursa, Türkiye.)0000-0003-4002-4659
Pages
—
Publication Date
2026-07-22
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These findings suggest that echocardiographic assessment of EAT and PAT may provide a simple and non-invasive marker for identifying subclinical vascular risk in patients with ED.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Patients with erectile dysfunction (ED) may exhibit early signs of endothelial and vascular impairment even in the absence of overt cardiovascular disease.
📊
Key Findings & Data:The medical records of 58 male patients presenting with ED were retrospectively reviewed.
💡
Conclusion & Impact:These findings suggest that echocardiographic assessment of EAT and PAT may provide a simple and non-invasive marker for identifying subclinical vascular risk in patients with ED.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Erektil disfonksiyon · Epikardiyal adipoz doku · Perikardiyal adipoz doku

Abstract

Patients with erectile dysfunction (ED) may exhibit early signs of endothelial and vascular impairment even in the absence of overt cardiovascular disease. This study aimed to investigate the relationship between epicardial adipose tissue (EAT) and pericardial adipose tissue (PAT) thickness measured by transthoracic echocardiography and the severity of ED in patients without known systemic comorbidities. The medical records of 58 male patients presenting with ED were retrospectively reviewed. Patients with hypertension, diabetes mellitus, coronary artery disease, or other significant systemic disorders were excluded. According to International Index of Erectile Function-5 (IIEF-5) scores, patients were divided into two groups as moderate-to-severe ED (Group 1, n=27) and mild ED-to-normal erectile function (Group 2, n=31). Demographic characteristics including age, height, weight, and body mass index were similar between the groups. However, significant differences were observed regarding cardiac adiposity measurements. Mean EAT thickness was significantly higher in Group 1 compared with Group 2 (0.75±0.19 mm vs. 0.53±0.18 mm, p=0.0015). Similarly, PAT thickness was greater in Group 1 than in Group 2 (0.85±0.11 mm vs. 0.61±0.17 mm, p<0.001). Although body mass index did not differ significantly between groups, increased local cardiac fat thickness appeared to be associated with ED severity. These findings suggest that echocardiographic assessment of EAT and PAT may provide a simple and non-invasive marker for identifying subclinical vascular risk in patients with ED.

Özet

Erektil disfonksiyonlu (ED) hastalarda, belirgin kardiyovasküler hastalık bulunmasa bile endotelyal ve vasküler bozukluğun erken belirtileri görülebilmektedir. Bu çalışmada, bilinen sistemik komorbiditesi olmayan ED hastalarında transtorasik ekokardiyografi ile ölçülen epikardiyal adipoz doku (EAT) ve perikardiyal adipoz doku (PAT) kalınlığı ile ED şiddeti arasındaki ilişkinin araştırılması amaçlandı. ED şikâyeti ile başvuran 58 erkek hastanın tıbbi kayıtları retrospektif olarak incelendi. Hipertansiyon, diyabetes mellitus, koroner arter hastalığı veya diğer önemli sistemik hastalıkları bulunan olgular çalışma dışı bırakıldı. Hastalar Uluslararası Erektil Fonksiyon İndeksi-5 (IIEF-5) skorlarına göre orta-ağır ED (Grup 1, n=27) ve hafif ED-normal erektil fonksiyon (Grup 2, n=31) olmak üzere iki gruba ayrıldı. Gruplar yaş, boy, kilo ve vücut kitle indeksi açısından benzerdi. Ancak kardiyak yağlanma ölçümleri açısından anlamlı farklılıklar saptandı. Ortalama EAT kalınlığı Grup 1’de Grup 2’ye göre anlamlı derecede yüksekti (0,75±0,19 mm’ye karşı 0,53±0,18 mm; p=0,0015). Benzer şekilde PAT kalınlığı da Grup 1’de Grup 2’ye kıyasla daha yüksekti (0,85±0,11 mm’ye karşı 0,61±0,17 mm; p<0,001). Vücut kitle indeksi açısından gruplar arasında anlamlı fark bulunmamasına rağmen, artmış lokal kardiyak yağ dokusu kalınlığının ED şiddeti ile ilişkili olabileceği görüldü. Bu bulgular, EAT ve PAT’ın ekokardiyografik değerlendirilmesinin ED hastalarında subklinik vasküler riskin belirlenmesinde basit ve non-invaziv bir belirteç olarak kullanılabileceğini düşündürmektedir.

🔖

Cite This Article

Yeni, S., Başel, M. C., Dursun, A., Aydın, Y. M., Gül, A., *, S. Y. (2026). Evaluation of the Relationship Between Erectile Dysfunction and Pericardial and Epicardial Adipose Tissue Thickness. Uludağ Üniversitesi Tıp Fakültesi Dergisi, Cilt: 52. https://doi.org/10.32708/uutfd.1950206

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Rew, Karl T.; Heıdelbaugh, Joel J. Erectile dysfunction. American family physician, 2016, 94.10: 820-827.
  2. Vlachopoulos C, Jackson G, Stefanadis C, Montorsi P. Erectiledysfunction and cardiovascular disease: the role of endothelialdysfunction and clinical implications. Eur Heart J.2021;42(11):1040-1050.
  3. Miner MM, Seftel AD, Nehra A, et al. Erectile dysfunction andcardiovascular disease: executive summary ofrecommendations. Mayo Clin Proc. 2022;97(3):466-475.
  4. Iacobellis G, Assael F, Ribaudo MC, et al. Epicardial fat fromechocardiography: a new method for visceral adipose tissueprediction. Obes Res. 2003;11(2):304-310.
  5. Iacobellis G. Epicardial adipose tissue in endocrine andmetabolic diseases. Endocrine. 2014;46:8-15.
  6. Matloch Z, Cinkajzlova A, Mraz M, et al. The role ofinflammation in epicardial adipose tissue in heart diseases. CurrPharm Des. 2018;24(3):297-309.
  7. Dozio E, Barassi A, Dogliotti G, et al. Adipokines, hormonal parameters, and cardiovascular risk factors: similarities anddifferences between patients with erectile dysfunction ofarteriogenic and nonarteriogenic origin. J Sex Med.2012;9(9):2370-2377.
  8. Roberts CK, Vaziri ND, Barnard RJ. Effect of diet and exercise intervention on blood pressure, insulin, oxidative stress, andnitric oxide availability. Circulation. 2002;106(20):2530-2536.
  9. Yu J, Liang P. Associations between inflammatory pathways,lipid metabolism, and erectile dysfunction: a clinical andmolecular perspective. Transl Androl Urol. 2024;13(12):2724-2734.
  10. Franssens BT, Nathoe HM, Leiner T, et al. Relation betweencardiovascular disease risk factors and epicardial adipose tissuedensity on cardiac computed tomography in patients at highrisk of cardiovascular events. Eur J Prev Cardiol.2017;24(6):660-670.
  11. Szasz T, Webb RC. Epicardial adipose tissue: emerging clinical implications in cardiovascular disease and metabolicdysfunction. Cardiovasc Diabetol. 2023;22:145.
  12. Liu J, Fox CS, Hickson D, et al. Pericardial adipose tissue,atherosclerosis, and cardiovascular disease risk factors: theJackson Heart Study. Diabetes Care. 2010;33(7):1635-1639.
  13. Salazar J, Luzardo E, Mejías JC, et al. Epicardial fat: physiological, pathological, and therapeutic implications.Cardiol Res Pract. 2016;2016:1291537.
  14. Iacobellis G, Corradi D, Sharma AM. Epicardial adipose tissue:anatomic, biomolecular and clinical relationships with theheart. Nat Rev Cardiol. 2005;2:536-543.
  15. Iacobellis G. Local and systemic effects of the multifacetedepicardial adipose tissue depot. Nat Rev Endocrinol.2015;11:363-371.
  16. Aydın H, Toprak A, Deyneli O, et al. Epicardial fat tissue thickness correlates with endothelial dysfunction and othercardiovascular risk factors in patients with metabolic syndrome.Metab Syndr Relat Disord. 2010;8(3):229-234.