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Journals / Eskisehir Medical Journal / 2026 / Volume: 7 Issue: 3

Can Tp-e Interval Be an Early Indicator of Radiotherapy-Induced Cardiac Damage?

Mehmet Cem Başel(VM Medical Park Bursa Hospital)0000-0002-5077-0527
Aydın Dursun(Mudanya University)0000-0003-2792-7685
Kemal Ekici(VM Medical Park Bursa Hospital)0000-0003-3222-9275
Kerem Can Yilmaz(Mudanya University)0000-0003-3320-9508
Pages
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Publication Date
2026-08-29
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Routine ECG monitoring may be beneficial in these patients.

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: This study aimed to evaluate the effects of radiotherapy (RT) on electrocardiographic parameters, including QT, corrected QT (QTc), Tp-e interval, and Tp-e/QT and Tp-e/QTc ratios, in patients with breast and lung cancer.
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Key Findings & Data:Methods: A total of 27 patients (15 with lung cancer and 12 with breast cancer) were included.
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Conclusion & Impact:Routine ECG monitoring may be beneficial in these patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:radiotherapy · Tp-e interval · arrhythmia

Abstract

Introduction: This study aimed to evaluate the effects of radiotherapy (RT) on electrocardiographic parameters, including QT, corrected QT (QTc), Tp-e interval, and Tp-e/QT and Tp-e/QTc ratios, in patients with breast and lung cancer. Methods: A total of 27 patients (15 with lung cancer and 12 with breast cancer) were included. The decision for RT was made by a multidisciplinary oncology board. Standard 12-lead electrocardiography (ECG) and transthoracic echocardiography were performed before and after RT. Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios were calculated. The mean myocardial radiation dose ranged between 5.0 and 6.5 Gy. Cardiac radiation exposure was similar between groups. Results: There were no significant changes in blood pressure, heart rate, or left ventricular ejection fraction after RT. However, Tp-e interval and Tp-e/QT ratio were significantly prolonged following RT in both groups. In patients with lung cancer, the Tp-e interval increased from 72.94±7.32 ms to 80.20±5.87 ms. In patients with breast cancer, it increased from 65.41±4.02 ms to 73.00±2.64 ms. Conclusion: Radiotherapy may lead to early alterations in ventricular repolarization parameters. Tp-e interval and related indices may serve as early markers of radiotherapy-induced cardiac damage. Routine ECG monitoring may be beneficial in these patients.

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Cite This Article

Başel, M. C., Dursun, A., Ekici, K., Yilmaz, K. C. (2026). Can Tp-e Interval Be an Early Indicator of Radiotherapy-Induced Cardiac Damage?. Eskisehir Medical Journal, Volume: 7 Issue: 3. https://ajindex.com/articles/1614170

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