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Journals / Ankara Üniversitesi Eczacılık Fakültesi Dergisi / 1984 / Cilt: 14 Sayı: 1

Studies o n t h e Synthesis, S t r u c t u r e E l u c i d a t i o n a n d Q u a n t i t a t i v e Local Anesthetic Activities of Benzoic Acid Esters - II

Benzoik Asit Esterlerinin Sentez, Yapı Açıklamaları ve Kant Lokal Anestezik Etkileri Üzerinde Çalışmalar - II

Tuncel Özden
Pages
37–52
Publication Date
1984-06-01
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As a result, 2-dialkylaminoethyl esters of 2,4-dimethylbenzoic acid were found mor e active tha n esters of 2,4-dimethoxybenzoic acids an d procaine HC1 .

📌 3 Key Takeaways

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Objective & Hypothesis:In this research, 10. 2-dialkylaminoethyl esters of 2,4-dimethoxy an d 2,4-dimethylbenzoic acids ha d been prepared and 7 of the m were original.
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Key Findings & Data:After the structur e elucidation their local anesthetic activities were found an d compare d with the activity of procain hydrochloride.
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Conclusion & Impact:As a result, 2-dialkylaminoethyl esters of 2,4-dimethylbenzoic acid were found mor e active tha n esters of 2,4-dimethoxybenzoic acids an d procaine HC1 .
🔬Design:Makale
📍Scope:Comprehensive Sample
⚙️Variables:Lokal Anestezi · Substitue benzoik asit · Esterler

Abstract

In this research, 10. 2-dialkylaminoethyl esters of 2,4-dimethoxy an d 2,4-dimethylbenzoic acids ha d been prepared and 7 of the m were original. After the structur e elucidation their local anesthetic activities were found an d compare d with the activity of procain hydrochloride. As a result, 2-dialkylaminoethyl esters of 2,4-dimethylbenzoic acid were found mor e active tha n esters of 2,4-dimethoxybenzoic acids an d procaine HC1 .

Özet

Bu çalışmada lokal anestezik etkili, 2,4-dimetoksi ve 2.4-dimetilbenzoik asitin 2-dialkilaminoetil esterleri hazırlanmış ve 7 si orjinal olan 10 bileşiğin yapıları kanıtlandıktan sonra kantitatif lokal anestezik etkileri prokain hidroklorür ile de mukayese edilerek verilmiştir. Sonuçta . 2.4-dimetilbenzolik asitin 2-dialkilaminoetil esterleri, 2,4-dimetoksibenzoik asit esterleri ve prokain HC1 den dah a etkili bulun - muştur.

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Cite This Article

Özden, T. (1984). Studies o n t h e Synthesis, S t r u c t u r e E l u c i d a t i o n a n d Q u a n t i t a t i v e Local Anesthetic Activities of Benzoic Acid Esters - II. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, Cilt: 14 Sayı: 1, 37–52. https://doi.org/10.1501/Eczfak_0000000101

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