AI Summary & Key Takeaways
AI InsightIn replicate analyses of a sample of Madopar capsules, satisfactory precision was demonstrated by the relative standard deviations of 1.41 % (I) and 1 . 1 6 % (II) for levodopa and 1.49 % for benserazide
📌 3 Key Takeaways
Abstract
Direct spectrophotometric methods for the simultaneous determination of levodopa and benserazide in combined formulations are presented. The methods are based on the use of UV derivative spectrophotometric measurements -the first derivative at 271.6 nm (I) and the second derivative at 239.4 nm (II) for levodopa (in 0.1 N hydrochloric acid) and the second derivative at 219.4 nm for benserazide (in 0.1 N hydrochloric acid). The mean percentage recoveries of the drugs by standard addition method were 100.6 % (I) and 99.2 % (II) for levodopa and 100.2 % for benserazide, respectively. In replicate analyses of a sample of Madopar capsules, satisfactory precision was demonstrated by the relative standard deviations of 1.41 % (I) and 1 . 1 6 % (II) for levodopa and 1.49 % for benserazide
Özet
Bu çalışmada, levodopa ve benserazidin kombine preparatlarından birarada tayini için spektrofotometrik yöntemler geliştirilmiştir. Yöntemler, levodopanın 0.1 N HCI'deki çözeltisinin birinci türev spektrumunda 271.6 nm de (I), ikinci türev spektrumunda 239.4 nm de (II) ve benserazidin 0.1 N HC1 deki çözeltisinin ikinci türev spektrumunda 219.4 nm de ölçümüne dayanmaktadır. Sözkonusu bileşiklerin standart ilavesi yöntemiyle % geriye kazanımları levodopa için % 100.6 (I) ve % 99.2 (11), benserazid için ise % 100.2 dir. Bu