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Journals / Ankara Üniversitesi Eczacılık Fakültesi Dergisi / 2026 / Cilt: 30 Sayı: 3

AN INVESTIGATION ON THE EFFECT OF N-NITROSOPYROLLIDINE ON THE RABBIT LIVER AND KIDNEY GLUTATHIONE-S-TRANSFERASE ACTIVITY

İN VİTRO ŞARTLARDA N- NİTROZOPROLİDİN'İN TAVŞAN KARACİĞER VE BÖBREK GLUTATYON -S- TRANSFERAZ AKTİVİTESİNE ETKİSİNİN ARAŞTIRILMASI

İzzet Yelkovan
İsmihan Göze
Sevtap Bakır
Pages
0–0
Publication Date
2001-09-01
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The result were expressed as spesific activities

📌 3 Key Takeaways

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Objective & Hypothesis:We analyzed the interaction of glutation- S- transferase, which is isolated from the liver and kidney of rabbits with N-nitrosopyrollidine which is an effective carsinojenic.
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Key Findings & Data:The activities observed were compared with that of the activity observed in the presence of 1 chloro 2, 4 dinitrobenzen as a substrate and a regression analysis was performed to investigate the correlation.
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Conclusion & Impact:The result were expressed as spesific activities
🔬Design:Makale
📍Scope:Comprehensive Sample
⚙️Variables:N-nitrozoprolidin · Glutatyon -S-transferaz

Abstract

We analyzed the interaction of glutation- S- transferase, which is isolated from the liver and kidney of rabbits with N-nitrosopyrollidine which is an effective carsinojenic. Glutathione-S-transferase enzymes were treated with N-nitrosopyrollidine in vitro conditions at various doses, and the reactions were recorded. The activities observed were compared with that of the activity observed in the presence of 1 chloro 2, 4 dinitrobenzen as a substrate and a regression analysis was performed to investigate the correlation. The result were expressed as spesific activities

Özet

Çalışmada tavşan karaciğerinden ve böbreklerinden izole edilen Glutatyon-S- Transferaz'ın kanserojen etkili bir madde olan N-nitrozoprolidin ile etkileşimi incelendi. Glutatyon -S-Transferaz enzimi in vitro şartlarda değişik dozlarda N-nitrozoprolidin ile muamele edilerek, reaksiyonları gözlendi. Bulgular 1 kloro 2 ,4 dinitro benzen (KDNB) substrat olarak kullanıldığında bulunan aktivite ile karşılaştırıldı. Regresyon ve korelasyon analizi yapıldı. Sonuçlar spesifik aktivite olarak verildi

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Cite This Article

Yelkovan, İ., Göze, İ., Bakır, S. (2001). AN INVESTIGATION ON THE EFFECT OF N-NITROSOPYROLLIDINE ON THE RABBIT LIVER AND KIDNEY GLUTATHIONE-S-TRANSFERASE ACTIVITY. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, Cilt: 30 Sayı: 3, 0–0. https://doi.org/10.1501/Eczfak_0000000361

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