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Journals / Ankara Üniversitesi Eczacılık Fakültesi Dergisi / 2018 / Cilt: 42 Sayı: 3

A RESEARCH FOR SOME OXAZOLIDINONES TO EVALUATE THEIR ANTIMICROBIAL ACTIVITY

YENİ OKSAZOLİDİNONLARIN ANTİMİKROBİYAL AKTİVİTELERİNİ DEĞERLENDİREN BİR ARAŞTIRMA

Canan Kus
Ezgi Ugurlu
Nurten Altanlar
Pages
32–37
Publication Date
2018-09-30
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Objectives: In this research, antimicrobial activity of some new oxazolidinone derivatives were evaluated against S. aureus ATCC 25923, E. coli ATCC 25922, B. subtilis ATCC 6633, methicillin-resistant Staphylococcus aureus (MRSA) clinical isolate and C. albicans ATCC 10231.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: In this research, antimicrobial activity of some new oxazolidinone derivatives were evaluated against S. aureus ATCC 25923, E. coli ATCC 25922, B. subtilis ATCC 6633, methicillin-resistant Staphylococcus aureus (MRSA) clinical isolate and C. albicans ATCC 10231.
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Key Findings & Data:Objectives: In this research, antimicrobial activity of some new oxazolidinone derivatives were evaluated against S. aureus ATCC 25923, E. coli ATCC 25922, B. subtilis ATCC 6633, methicillin-resistant Staphylococcus aureus (MRSA) clinical isolate and C. albicans ATCC 10231.
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Conclusion & Impact:Objectives: In this research, antimicrobial activity of some new oxazolidinone derivatives were evaluated against S. aureus ATCC 25923, E. coli ATCC 25922, B. subtilis ATCC 6633, methicillin-resistant Staphylococcus aureus (MRSA) clinical isolate and C. albicans ATCC 10231.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:antimikrobiyal aktivite · linezolid · oksazolidinon

Abstract

Objectives: In this research, antimicrobial activity of some new oxazolidinone derivatives were evaluated against S. aureus ATCC 25923, E. coli ATCC 25922, B. subtilis ATCC 6633, methicillin-resistant Staphylococcus aureus (MRSA) clinical isolate and C. albicans ATCC 10231.

Özet

Amaç: Bu çalışmada, bazı yeni oksazolidinon türevlerinin antimikrobiyal etkileri S. aureus ATCC 25923, E. coli ATCC 25922, B. subtilis ATCC 6633, metisilin-dirençli Staphylococcus aureus (MRSA) klinik izolatı ve C. albicans ATCC 10231’e karşı incelenmiştir. Gereç ve Yöntem: Daha önce elde edilen ve yayınlanan 10 oksazolidinonların antimikrobiyal aktivitesi test edilmiştir ve çalışma Mueller-Hinton broth ve Sabouraud dekstroz broth içinde gerçekleştirilmiştir. Sonuç ve Tartışma: E5 ve E9 bileşikleri, sırasıyla, 25 μg/mL ve 50 μg/mL ile hem bakteri hem de mantarlara karşı antimikrobiyal aktivite göstermiştir. Bizim bu araştırmamız ve diğer bazı çalışmalar, elektro-negatiflik derecesinin biyolojik aktivite için çok önemli olduğunu göstermiştir.

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Cite This Article

Kus, C., Ugurlu, E., Altanlar, N. (2018). A RESEARCH FOR SOME OXAZOLIDINONES TO EVALUATE THEIR ANTIMICROBIAL ACTIVITY. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, Cilt: 42 Sayı: 3, 32–37. https://ajindex.com/articles/1104112

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References (14)

  1. Das, B., Rajarao, AVS., Sonalı, R., Yadav, A., Ray, A., Pandya, M., Rattan, A., Mehta, A. (2009). Synthesis and biological activity of novel oxazolidinones. Bioorganical and Medicinal Chemistry Letters, 19, 6424-6428.
  2. Desai, K.R., Mistry, R.N. (2005). Studies on Synthesis of Some Novel Heterocyclic Azlactone Derivatives and Imidazolinone Derivatives and their Antimicrobial Activity. E-Journal Chemistry, 2, 42-51.
  3. El-Gohary, N.S., Shaaban, M.I. (2017). Synthesis, antimicrobial, antiquorum-sensing and antitumor activities of new benzimidazole analogs. European Journal of Medicinal Chemistry, 137, 439-449.
  4. Zhu, M., Gokhale, V.M., Szabo, L., Munoz, R.M., Baek, H., Bashyam, S., Hurley, L.H., Von Hoff, D.D., Han, H. (2007). Identification of a novel inhibitor of urokinase-type plasminogen activator. Molecular Cancer Theraphy, 6, 1348-1356.
  5. Kuzikov, A.V., Dugin, N.O., Stulov, S.V., Shcherbinin, D.S., Zharkova, M.S., Tkachev, Y.V.,Timofeev, V.P., Veselovsky, A.V., Shumyantseva, V.V., Misharin, A.Y. (2014) Novel oxazolinyl derivatives of pregna- 5,17(20)-diene as 17α-hydroxylase/17,20-lyase (CYP17A1) inhibitors. Steroids, 88, 66-71.
  6. Diacon, A.H., Groote-Bidlingmanier, F., Donald, P.R. (2014). A new 6-nitro-2,3-dihydroimidazo-[2,1-b]oxazole for the management of tuberculosis resistant to at least isoniazid and rifampisin. Expert Opinion on Orphan Drugs, 2, 87-94.
  7. Garg, P., Chaudhary, S., Milton, M.D. (2014) Synthesis of 2-Aryl/Heteroaryloxazolines from Nitriles under Metal and Catalyst-Free Conditions and Evaluation of Their Antioxidant Activities. Journal of Organic Chemistry, 79, 8668−8677.
  8. Temiz-Arpaci, O., Coban, T., Tekiner-Gulbas, B., Can-Eke, B., Yildiz, I., Aki-Sener, E., Yalcin, I., Iscan, M.A. (2006). Study on the antioxidant activities of some new benzazole derivatives. Acta Biologica Hungarica, 57, 201-209.
  9. Mariappan, G., Saha, B.P., Datta, S., Kumar, D., Haldar, P.K. (2011) Design, synthesis and antidiabetic evaluation of oxazolone derivatives. Journal of Chemical Science, 123, 335-334.
  10. Brickner, S.J., Hutchinson, D.K., Barbachyn, M.R., Manninen, P.R., Ulanowicz, D.A., Garmon, K.C., Hendges, S.K., Toops, D.S., Ford, C.W., Zurenko, G.E. (1996). Synthesis and Antibacterial Activity of U-100592 and U-100766, Two Oxazolidinone Antibacterial Agents for the Potential Treatment of Multidrug-Resistant Gram-Positive Bacterial Infections. Journal of Medicinal Chemistry, 39, 673-679.
  11. Kuş, C., Uğurlu, E., Özdamar, E.D., Can-Eke, B. (2017). Synthesis and Antioxidant Properties of New Oxazole-5(4H)-one Derivatives. Turkish Journal of Pharmaceutical Sciences, 14(2), 174-178.
  12. NCCLS. (2000). Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard, 5th ed. NCCLS document. M7-A5. NCCLS.
  13. Wayne, P.A. (2012). CLSI. Methods For Dilution Antimicrobial Susceptibility Tests For Bacteria That Grow Aerobically; Approved Standard 9 Th Edition. CLSI Document M07-A9: Clinical and Laboratory Standards Institute.
  14. Wayne, P.A. (2015). Performance Standards For Antimicrobial Disk Susceptibility Tests; Approved Standard 12th Edition, CLSI Document, M02, A12.