SavedAdd your journal

Journals / Ankara Üniversitesi Eczacılık Fakültesi Dergisi / 2026 / Cilt: 45 Sayı: 1

THE ROLE OF GLUTATION-S-TRANSFERASE MU1 AND TETA1 POLYMORPHISMS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE

KRONİK OBSTRÜKTİF AKCİĞER HASTALIĞINDA GLUTATYON-S-TRANSFERAZ MU1 VE TETA1 POLİMORFİZMLERİNİN ROLÜ

Buket Hayat(KIRIKKALE ÜNİVERSİTESİ, FEN-EDEBİYAT FAKÜLTESİ)0000-0001-8234-0313
Muhsin Selçuk Yavuz(ANKARA POLATLI DUATEPE DEVLET HASTANESİ)0000-0002-0198-9506
Mustafa Engin Şahin(ANKARA ATATÜRK GÖĞÜS HASTALIKLARI VE GÖĞÜS CERRAHİSİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0002-2707-8196
Onur Dirican(KIRIKKALE ÜNİVERSİTESİ, FEN-EDEBİYAT FAKÜLTESİ)0000-0003-0511-6611
Sezen Yılmaz(ANKARA ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ)0000-0002-8387-4146
Can Yılmaz(VAN YÜZÜNCÜ YIL ÜNİVERSİTESİ, FEN FAKÜLTESİ)0000-0002-0028-6614
Işıl Yıldırım(BEYKENT ÜNİVERSİTESİ, MESLEK YÜKSEKOKULU)0000-0002-3027-6054
Tülay Çoban(ANKARA ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ)0000-0002-9696-6613
Gülçin Güler Şimşek(ANKARA KEÇİÖREN SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0001-7710-4631
Serpil Oğuztüzün(KIRIKKALE ÜNİVERSİTESİ, FEN-EDEBİYAT FAKÜLTESİ)0000-0002-5892-3735
Pages
41–56
Publication Date
2021-01-18
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Objective: The aim of this study the investigation of "null" alleles in GSTM1 and GSTT1 gene regions in the development of COPD disease.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The aim of this study the investigation of "null" alleles in GSTM1 and GSTT1 gene regions in the development of COPD disease.
📊
Key Findings & Data:Objective: The aim of this study the investigation of "null" alleles in GSTM1 and GSTT1 gene regions in the development of COPD disease.
💡
Conclusion & Impact:Objective: The aim of this study the investigation of "null" alleles in GSTM1 and GSTT1 gene regions in the development of COPD disease.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Delesyon · GST İzozimleri · KOAH

Abstract

Objective: The aim of this study the investigation of "null" alleles in GSTM1 and GSTT1 gene regions in the development of COPD disease.

Özet

Amaç: Çalışmamızın amacı, KOAH hastalığının oluşumunda GSTM1 ve GSTT1 gen bölgesindeki “null” allellerinin rolü olup olmadığını araştırmaktır.

🔖

Cite This Article

Hayat, B., Yavuz, M. S., Şahin, M. E., Dirican, O., Yılmaz, S., Yılmaz, C., Yıldırım, I., Çoban, T., Şimşek, G. G., Oğuztüzün, S. (2021). THE ROLE OF GLUTATION-S-TRANSFERASE MU1 AND TETA1 POLYMORPHISMS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, Cilt: 45 Sayı: 1, 41–56. https://doi.org/10.33483/jfpau.839530

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (26)

  1. Celi BR, MacNee W. Standarts fort he diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J 2004; 23: 932.
  2. Menezes AM, Perez-Padilla P, Jardim JR, et al. Chronic obstructive pulmonary disease in five Latin American cities (the PLATİNO study): a prevalence study. Lancet 2005; 366: 1875-81.
  3. Gunen H, Hacievliyagil SS, Yetkin O, et al. Prevalence of COPD: first epidemiological study of a large region in Turkey. Eur J Intern Med 2008; 19: 499-504.
  4. Oulette DR. The answer is fifteen percent: what is the question? Chest 2004;125:3-5.
  5. Lozano R, Naghavi M, Foreman K, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380:2095-128.
  6. http://www.who.int/respiratory/copd/burden/en/index.html (Erişim tarihi; 24.03.2010).
  7. Global Initiative for Chronic Obstructive Lung Disease: Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease (Güncelleme 2016).
  8. McGinnis JM, Williams-Russo P, Knickman JR. The case for more active policy attention to health promotion. Health Affairs 2012;21:78-93.
  9. Hooper R, Burney P, Vollmer WM, et al. Risk factors for COPD spirometrically defined from the lower limit of normal in the BOLD Project. Eur Respir J 2012;39:1343-53.
  10. Crawford EL, Khuder SA, Durham SJ, Frampton M, Utell M, Thilly WG, et al. Normal bronchial epithelial cell expression of glutathione transferase P1, glutathione transferase M3, and glutathione peroxidase is low in subjects with bronchogenic carcinoma. Cancer Res 2000: 60: 1609-18.
  11. Han W, Pentecost BT, Pietropaolo RL, Fasco MJ, Spivack SD. Estrogen receptor alpha increases basal and cigarette smoke extract-induced expression of CYP1A1 and CYP1B1, but not GSTP1, in normal human bronchial epithelial cells. Mol Carcinog 2005; 44: 202-11.
  12. Landi S. Mammalian class theta GST and differential susceptibility to carcinogens: a review. Mutat Res 2000; 463: 247-83.
  13. Teramoto S. 1. COPD Pathogenesis from the Viewpoint of Risk Factors. Japanese Journal of Medicine 2007: 46: 77-79.
  14. Ding Z, Wang K, Li J, Tan Q, Tan W, Guo G. Association between glutathione S-transferase gene M1 and T1 polymorphisms and chronic obstructive pulmonary disease risk: a meta-analysis. Clin Genet 2019;95:53–62.
  15. Hemimi NED, Attar MA, Abd Elwahab MA. Genetic Polymorphism Of Glutathione-S Transferase And Susceptibility To And Severity Of Chronic Obstructive Pulmonary Disease. The FASEB Journal. 2009: 27: 117-128.
  16. Vasudevan, Sreekumarı, & Vaıdyanathan, 2011)-( Vasudevan, D., Sreekumarı, S., & Vadyanathan, K. (2011). Textbook Of Biochemistry For Medical Students (Sixth Edition b.). New Delhi India: Jaypee Brothers Medical Publishers (P) Ltd,).
  17. Girault I, Lidereau R, Bièche I. Trimodal GSTT1 and GSTM1 genotyping assay by real-time PCR. Int J Biol Markers. 2005 Apr-Jun;20(2):81-6. PMID: 16011037.
  18. Vogelmeier CF, Criner GJ, Martinez FJ et al. Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary. Respirology 2017: 22: 575-601.
  19. Strange RC, Fryer AA. The glutathione S-transferases: influence of polymorphism on cancer susceptibility. Iarc Scientific Publications 1999: 148: 231.
  20. Hu G, Yao W, Zhou Y et al. Meta- and pooled analyses of the effect of glutathione S transferase M1 and T1 deficiency on chronic obstructive pulmonary disease. International Journal of Tuberculosis & Lung Disease the Official Journal of the International Union Against Tuberculosis & Lung Disease 2008: 12: 1474 1481.
  21. Shukla RK, Kant S, Bhattacharya S et al. Association of Genetic Polymorphism of GSTT1, GSTM1 and GSTM3 in COPD Patients in a North Indian Population. Copd Journal of Chronic Obstructive Pulmonary Disease 2011: 8: 167-172.
  22. Tkacova R, Salagovic J, Ceripkova M et al. Glutathione S-transferase M1 gene polymorphism is related to COPD in patients with non-small-cell lung cancer. Wiener Klinische Wochenschrift 2004: 116: 131-134.
  23. Castaldi PJ, Cohn CM, Langerman F et al. The COPD genetic association compendium: a comprehensive online database of COPD genetic associations. Human Molecular Genetics 2010: 19: 526.
  24. Dimov D, Vlaykova T, Kurzawski M et al. Effect of genetic polymorphisms of some cytokines and xenobiotic-metabolizing enzymes on the lung function in patients with COPD. European Respiratory Journal 2012: 1750.
  25. Silverman EK, Weiss ST, Drazen JM, et al. Gender relateddifferences in severe, early onset chronic obstructivepulmonary disease. Am J Respir Crit Care Med 2000; 162:2152–2158.
  26. Pilar C-G, Javier M-D, Javier R-G, Antonio M-Co, Elena G-V, Valentin H B, Angel G M, Rodrigo J-G, Characteristics of chronic obstructive pulmonary disease in Spain from a gender perspective BMC Pulmonary Medicine prepublished online 2009; 9:2.