Objective: Synthesis and nanosuspension preparation of iodine-based triiodoaniline (TIA) radiocontrast compound, which is not soluble in water, perform their characterization and compare with iopromide and iohexol, which are frequently used in Computed Tomography (CT) imaging.
📌 3 Key Takeaways
🎯
Objective & Hypothesis:Objective: Synthesis and nanosuspension preparation of iodine-based triiodoaniline (TIA) radiocontrast compound, which is not soluble in water, perform their characterization and compare with iopromide and iohexol, which are frequently used in Computed Tomography (CT) imaging.
📊
Key Findings & Data:Objective: Synthesis and nanosuspension preparation of iodine-based triiodoaniline (TIA) radiocontrast compound, which is not soluble in water, perform their characterization and compare with iopromide and iohexol, which are frequently used in Computed Tomography (CT) imaging.
💡
Conclusion & Impact:Objective: Synthesis and nanosuspension preparation of iodine-based triiodoaniline (TIA) radiocontrast compound, which is not soluble in water, perform their characterization and compare with iopromide and iohexol, which are frequently used in Computed Tomography (CT) imaging.
Objective: Synthesis and nanosuspension preparation of iodine-based triiodoaniline (TIA) radiocontrast compound, which is not soluble in water, perform their characterization and compare with iopromide and iohexol, which are frequently used in Computed Tomography (CT) imaging.
Özet
Amaç: Suda çözünürlüğü bulunmayan iyot bazlı triiyodoanilin (TIA) radyokontrast bileşiğinin sentezini ve nanosüspansiyonunu yapmak, karakterizasyonlarını gerçekleştirmek ve Bilgisayarlı Tomografi (BT) görüntülemede sıklıkla kullanılan iopromid ve ioheksol ile kıyaslamak.
Koca, M., Özakar, E., Özakar, R. S. (2021). SYNTHESIS OF TRIIODOANILINE, PREPARATION OF NANOSUSPENSIONS, IN VITRO CHARACTERIZATION AND INVESTIGATION OF RADIOCONTRAST PROPERTIES. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, Cilt: 45 Sayı: 2, 264–283. https://doi.org/10.33483/jfpau.811737
Caschera, L., Lazzara, A., Piergallini, L., Ricci, D., Tuscano, B., Vanzulli, A. (2016). Contrast agents in diagnostic imaging: Present and future. Pharmacological Research, 110, 65-75.
Koc, M.M., Aslan, N., Kao, A.P., Barber, A.H. (2019). Evaluation of X-ray tomography contrast agents: A review of production, protocols, and biological applications. Microscopy Research and Technique, 82(6), 812-848.
Almen, T. (1985). Development of nonionic contrast-media. Investigative Radiology, 20(1), 2-9.
Müller, R.H., Gohla, S., Keck, C.M. (2011). State of the art of nanocrystals – Special features, production,nanotoxicology aspects and intracellular delivery. European Journal of Pharmaceutics and Biopharmaceutics, 78, 1-9.
Wang, Y., Zheng, Y., Zhang, L., Wang, Q., Zhang, D. (2013). Stability of nanosuspensions in drug delivery. Journal of Controlled Release, 172, 1126-1141.
Gao, L., Liu, G., Ma, J., Wang, X., Zhou, L., Li, X. (2012). Drug nanocrystals:In vivo performances. Journal of Controlled Release, 160, 418-430.
Wang, L.L., Du, J., Zhou, Y.Q., Wang, Y.C. (2017). Safety of nanosuspensions in drug delivery. Nanomedicine: Nanotechnology, Biology, and Medicine, 13(2), 455-469.
Kamaly, N., He, J.C., Ausiello, D.A., Farokhzad, O.C. (2016). Nanomedicines for renal disease: current status and future applications. Nature Reviews Nephrology, 12(12), 738-753.
Khan, I., Saeed, K., Khan, I. (2019). Nanoparticles: Properties, applications and toxicities. Arabian Journal of Chemistry, 12(7), 908-931.
Sahu, B.P., Das, M.K. (2014). Nanosuspension for enhancement of oral bioavailability of felodipine. Applied Nanoscience, 4(2), 189-197.
Ferreira, I.M., Casagrande, G.A., Pizzuti, L., Raminelli, C. (2014). Ultrasound-promoted rapid and efficient iodination of aromatic and heteroaromatic compounds in the presence of iodine and hydrogen peroxide in water. Synthetic Communications, 44(14), 2094-2102.
Rao, J.P., Geckeler, K.E. (2011). Polymer nanoparticles: Preparation techniques and size-control parameters. Progress in Polymer Science, 36(7), 887-913.
Pirimoglu, B., Sade, R., Sakat, M.S., Ogul, H., Levent, A., Kantarci, M. (2018). Low-dose noncontrast examination of the paranasal sinuses using volumetric computed tomography. Journal of Computer Assisted Tomography, 42(3), 482-486.
Pirimoglu, B., Sade, R., Sakat, M.S., Polat, G., Kantarci, M. (2019). Low-dose non-contrast examination of the temporal bone using volumetric 320-row computed tomography. Acta Radiologica, 60(7), 908-916.
Ravichandran, R. (2009). Nanoparticles in drug delivery: Potential green nanobiomedicine applications. International Journal of Green Nanotechnology: Biomedicine, 1(2), 108-130.
De Simone, B., Ansaloni, L., Sartelli, M., Gaiani, F., Leandro, G., De' Angelis, G.L., Di Mario, F., Coccolini, F., Catena, F. (2018). Is the risk of contrast-induced nephropathy a real contraindication to perform intravenous contrast enhanced Computed Tomography for non-traumatic acute abdomen in Emergency Surgery Department?. Acta Biomedica, 89(9-S), 158-172.
Mohammed, N.M.A., Mahfouz, A., Achkar, K., Rafie, I.M., Hajar, R. (2013). Contrast-induced nephropathy. Heart Views: The Official Journal of the Gulf Heart Association, 14(3), 106-116.
Cosmai, L., Porta, C., Privitera, C., Gesualdo, L., Procopio, G., Gori, S., et al. (2020). Acute kidney injury from contrast-enhanced CT procedures in patients with cancer: White paper to highlight its clinical relevance and discuss applicable preventive strategies. ESMO Open, 5(2), 1-8.
Sovak, M., Ranganathan, R. (1980). Stability of nonionic water-soluble contrast media: implications for their design. Investigative Radiology, 15(6), S323-328.
Han, X.J., Xu, K., Taratula, O., Farsad, K. (2019). Applications of nanoparticles in biomedical imaging. Nanoscale, 11(3), 799-819.
Hainfeld, J.F., Ridwan, S.M., Stanishevskiy, Y., Smilowitz, N.R., Davis, J., Smilowitz, H.M. (2018). Small, long blood half-life iodine nanoparticle for vascular and tumor imaging. Scientific Reports, 8, 1-10.
Kim, J., Lee, N., Hyeon, T. (2017). Recent development of nanoparticles for molecular imaging. Philosophical Transactions of the Royal Society A, 375(2107), 1-17.
Patel, V.R., Agrawal, Y. (2011). Nanosuspension: An approach to enhance solubility of drugs. Journal of Advanced Pharmaceutical Technology & Research, 2(2), 81-87.
Sutradhar, K.B., Khatun, S., Luna, I.P. (2013). Increasing possibilities of nanosuspension. Journal of Nanotechnology, 2013, 1-12.
Rabinow, B., Kipp, J., Papadopoulos, P., Wong, J., Glosson, J., Gass, J., et al. (2007). Itraconazole IV nanosuspension enhances efficacy through altered pharmacokinetics in the rat. International Journal of Pharmaceutics, 339(1-2), 251-260.
Merisko-Liversidge, E., Liversidge, G.G., Cooper, E.R. (2003). Nanosizing: A formulation approach for poorly-water-soluble compounds. European Journal of Pharmaceutical Sciences, 18(2), 113-120.
Peters, K., Leitzke, S., Diederichs, J.E., Borner, K., Hahn, H., Müller, R.H., Ehlers, S. (2000). Preparation of a clofazimine nanosuspension for intravenous use and evaluation of its therapeutic efficacy in murine Mycobacterium avium infection. Journal of Antimicrobial Chemotherapy, 45(1), 77-83.
Kalvakuntla, S., Deshpande, M., Attari, Z., Kunnatur, K. (2016). Preparation and characterization of nanosuspension of aprepitant by H96 process. Advanced Pharmaceutical Bulletin, 6(1), 83-90.
Singare, D.S., Marella, S., Gowthamrajan, K., Kulkarni, G.T., Vooturi, R., Rao, P.S. (2010). Optimization of formulation and process variable of nanosuspension: An industrial perspective. International Journal of Pharmaceutics, 402(1-2), 213-220.
Singh, S., Singh, S.K., Chauhan, M.G., Kumar, B., Pandey, N.K., Kaur, B., Kumar, A., Mohanta, S., Gulati, M., Wadhwa, S., Yadav, A.K., Singh, P.K., Kumari, Y., Kaur, G., Khursheed, R., Clarisse, A. (2019). Quality by design-based optimization of formulation and process variables for controlling particle size and zeta potential of spray dried incinerated copper nanosuspension. Recent Innovations in Chemical Engineering, 12(3), 248-260.
Karakucuk, A., Celebi, N. (2020). Investigation of formulation and process parameters of wet media milling to develop etodolac nanosuspensions. Pharmaceutical Research, 37, 1-18.
Ali, H.S., York, P., Blagden, N. (2009). Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics, 375(1-2), 107-113.
Patravale, V.B., Date, A.A., Kulkarni, R.M. (2004). Nanosuspensions: A promising drug delivery strategy. Journal of Pharmacy and Pharmacology, 56, 827-840.
Moorthi, C., Krishnan, K., Manavalan, R., Kathiresan, K. (2012). Preparation and characterization of curcumin–piperine dual drug loaded nanoparticles. Asian Pacific Journal of Tropical Biomedicine, 2(11), 841-848.
Afifi, S.A., Hassan, M.A., Abdelhameed, A.S., Elkhodairy, K.A. (2015). Nanosuspension: An emerging trend for bioavailability enhancement of etodolac. International Journal of Polymer Science, 2015, 1-16.
Wiśniewska, M., Ostolska, I., Szewczuk-Karpisz, K., Chibowski, S., Terpiłowski, K., Gun’ko, V.M., Zarko, V.I. (2015). Investigation of the polyvinyl alcohol stabilization mechanism and adsorption properties on the surface of ternary mixed nanooxide AST 50 (Al2O3–SiO2–TiO2). Journal of Nanoparticle Research, 17(12), 1-14.
Abdelbary, A.A., Li, X., El-Nabarawi, M., Elassasy, A., Jasti, B. (2013). Effect of fixed aqueous layer thickness of polymeric stabilizers on zeta potential and stability of aripiprazole nanosuspensions. Pharmaceutical Development and Technology, 18(3), 730-735.
Müller, R., Jacobs, C. (2002). Buparvaquone mucoadhesive nanosuspension: preparation, optimisation and long-term stability. International Journal of Pharmaceutics, 237(1-2), 151-161.
Mohammed, N.M.A., Mahfouz, A., Achkar, K., Rafie, I.M., Hajar, R. (2013). Contrast-induced nephropathy. Heart Views: The Official Journal of the Gulf Heart Association, 14(3), 106-116.