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Journals / Ankara Üniversitesi Eczacılık Fakültesi Dergisi / 2026 / Cilt: 46 Sayı: 2

EFFECT OF MINOCYCLINE AND MINOSCYCLINE+METFORMIN ON EXPERIMENTAL DIABETES-RELATED DEPRESSION

DENEYSEL DİYABETİN NEDEN OLDUĞU DEPRESYON TEDAVİSİNDE MİNOSİKLİN VE MİNOSİKLİN+METFORMİN KULLANIMI

Merve İnci Çamçi(DICLE UNIVERSITY, FACULTY OF PHARMACY)0000-0002-1670-1683
Meral Erdinç(DİCLE ÜNİVERSİTESİ)0000-0001-5591-7607
Emre Uyar(İNÖNÜ ÜNİVERSİTESİ)0000-0001-9941-1237
İlker Kelle(DİCLE ÜNİVERSİTESİ)0000-0003-3232-7019
Pages
432–443
Publication Date
2022-05-29
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This study aimed to reveal the effects of minocycline alone or in combination with metformin, which is used in the treatment of diabetes, on diabetes-related depression.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Minocycline is a second-generation tetracycline group antibiotic that acts on the central nervous system.
📊
Key Findings & Data:Minocycline reduces microglial activation and has anti-inflammatory, anti-apoptotic, and antioxidant properties.
💡
Conclusion & Impact:This study aimed to reveal the effects of minocycline alone or in combination with metformin, which is used in the treatment of diabetes, on diabetes-related depression.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Depresyon · diyabet · minosiklin

Abstract

Objective: Minocycline is a second-generation tetracycline group antibiotic that acts on the central nervous system. Minocycline reduces microglial activation and has anti-inflammatory, anti-apoptotic, and antioxidant properties. Recently, it has been proposed that there is a bidirectional relationship between diabetes and depression and that inflammation is one of the common pathways in their pathophysiology. The effects of minocycline on depression were then investigated. This study aimed to reveal the effects of minocycline alone or in combination with metformin, which is used in the treatment of diabetes, on diabetes-related depression.

Özet

Amaç: Minosiklin, santral sinir sistemine geçebilen, ikinci kuşak tetrasiklin grubu bir antibiyotiktir. Minosiklinin anti-inflamatuar, mikroglial aktivasyonu azaltma, anti-apoptotik, antioksidan özellikleri olduğu bilinmektedir. Son yıllarda diyabet ve depresyon arasında çift yönlü bir ilişki olduğunun ve fizyopatolojilerinde ortak yolaklardan birinin inflamasyon olduğunun ileri sürülmesi ile minosiklinin depresyon üzerine etkileri çalışılmaya başlanmıştır. Bu çalışmada minosiklinin tek başına ve diyabet tedavisinde kullanılan metformin ile kombinasyonu şeklinde kullanımının, diyabet ile ilişkili depresyon üzerine etkilerinin ortaya konması amaçlandı.

🔖

Cite This Article

Çamçi, M. İ., Erdinç, M., Uyar, E., Kelle, İ. (2022). EFFECT OF MINOCYCLINE AND MINOSCYCLINE+METFORMIN ON EXPERIMENTAL DIABETES-RELATED DEPRESSION. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, Cilt: 46 Sayı: 2, 432–443. https://doi.org/10.33483/jfpau.1098642

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