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Journals / Ankara Üniversitesi Eczacılık Fakültesi Dergisi / 2025 / Cilt: 49 Sayı: 2

NEUROPHARMACOLOGICAL EVALUATION OF AQUEOUS EXTRACTS OF FRUIT PEELS AND THEIR POLYHERBAL FORMULATION: ANTIDEPRESSANT AND MUSCLE RELAXANT POTENTIAL

MEYVE KABUKLARININ SULU EKSTRELERİ VE POLİBİTKİSEL FORMÜLASYONUNUN NÖROFARMAKOLOJİK DEĞERLENDİRİLMESİ: ANTİDEPRESAN VE KAS GEVŞETME POTANSİYELİ

Aruna Kumari Dokkada(Vignan Institute of Pharmaceutical Technology)0000-0001-8167-6456
Vijay Srinivas Pothula(Stira Pharma LLC)0000-0003-1496-8226
Gana Manjusha Kondepudi(VIGNAN INSTITUTE OF PHARMACEUTICAL TECHNOLOGY)0000-0002-7982-6934
Pages
329–338
Publication Date
2025-05-19
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, a more comprehensive investigation is required to elucidate the precise mechanisms underlying the antidepressant effects of the selected peel extracts and PHF.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: This study aims to assess the neuropharmacological properties of peels from specific fruits, namely Annona squamosa, Cucumis melo, Actinidia deliciosa, Malus pumila.
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Key Findings & Data:Material and Method: Wistar albino rats (weighing 150 g), regardless of gender, were allocated into six groups for forced swim tests, locomotion assessments, and muscle coordination evaluations.
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Conclusion & Impact:However, a more comprehensive investigation is required to elucidate the precise mechanisms underlying the antidepressant effects of the selected peel extracts and PHF.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Meyve kabukları · nörolojik aktivite · polibitkisel karışım

Abstract

Objective: This study aims to assess the neuropharmacological properties of peels from specific fruits, namely Annona squamosa, Cucumis melo, Actinidia deliciosa, Malus pumila. Material and Method: Wistar albino rats (weighing 150 g), regardless of gender, were allocated into six groups for forced swim tests, locomotion assessments, and muscle coordination evaluations. Diazepam and imipramine were employed as reference standards. At doses of 200 and 400 mg/kg, all peel extracts showed a reduction in immobility time, improved rotarod performance, and a notable increase in locomotor activity. Result and Discussion: The efficacy ranking for immobility time was as follows PHF>APMP>APCM>APAS>APAD. In terms of skeletal muscle relaxation, the order of effectiveness was: PHF>APCM>APMP>APAD>APAS and the treatment groups' locomotor activity followed this sequence: PHF>APMP>APCM>APAD>APAS. All the selected peel extracts exhibited noteworthy effects on immobility, locomotor activity, and muscle relaxation. However, a more comprehensive investigation is required to elucidate the precise mechanisms underlying the antidepressant effects of the selected peel extracts and PHF.

Özet

Amaç: Bu çalışma, Annona squamosa, Cucumis melo, Actinidia deliciosa, Malus pumila gibi belirli meyvelerin kabuklarının nörofarmakolojik özelliklerini değerlendirmeyi amaçlamaktadır. Gereç ve Yöntem: Wistar albino sıçanlar (ağırlıkları 150 g) cinsiyete bakılmaksızın zorunlu yüzme testleri, hareket değerlendirmeleri ve kas koordinasyonu değerlendirmeleri için altı gruba ayrıldı. Referans standartlar olarak diazepam ve imipramin kullanıldı. 200 ve 400 mg/kg dozlarında, tüm kabuk ekstraktları hareketsizlik süresinde azalma, rotarod performansında iyileşme ve lokomotor aktivitede kayda değer bir artış gösterdi. Sonuç ve Tartışma: Hareketsizlik süresine ilişkin etkinlik sıralaması şu şekildeydi: PHF>APMP>APCM >APAS>APAD. İskelet kası gevşemesi açısından etkinlik sırası şu şekildeydi: PHF>APCM>APMP>APAD>APAS ve tedavi gruplarının lokomotor aktivitesi şu sırayı takip etti: PHF>APMP>APCM>APAD>APAS. Seçilen tüm kabuk özleri hareketsizlik, lokomotor aktivite ve kas üzerinde kayda değer etkiler sergiledi.

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Cite This Article

Dokkada, A. K., Pothula, V. S., Kondepudi, G. M., *, G. M. K. (2025). NEUROPHARMACOLOGICAL EVALUATION OF AQUEOUS EXTRACTS OF FRUIT PEELS AND THEIR POLYHERBAL FORMULATION: ANTIDEPRESSANT AND MUSCLE RELAXANT POTENTIAL. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, Cilt: 49 Sayı: 2, 329–338. https://doi.org/10.33483/jfpau.1548158

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