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Journals / Ankara Üniversitesi Eczacılık Fakültesi Dergisi / 2026 / Cilt: 49 Sayı: 3

EXAMINATION OF SOME POTENTIAL MEDICINAL PLANT SPECIES IN THE TREATMENT OF ALOPECIA AREATA

ALOPESİ AREATA TEDAVİSİNDE POTANSİYEL BAZI TIBBİ BİTKİ TÜRLERİNİN İNCELENMESİ

Tuba Serbetcı(ÇUKUROVA ÜNİVERSİTESİ)0000-0002-9545-152X
Hanadi Bekir İbrahim(Çukurova üniversitesi)0009-0000-7194-8083
Pages
940–962
Publication Date
2025-09-19
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, further research is required to elucidate the mechanisms of action of some of these plants.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Alopecia areata (AA) is an autoimmune disease that causes hair loss due to the body’s immune system attacking hair follicles.
📊
Key Findings & Data:Result and Discussion: In recent years, the use of natural plant extracts in the treatment of Alopecia Areata has gained to significant attention.
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Conclusion & Impact:However, further research is required to elucidate the mechanisms of action of some of these plants.
🔬Design:Derleme
📍Scope:Comprehensive Sample
⚙️Variables:Alopesi areata · bitki ekstresi · saç uzaması

Abstract

Objective: Alopecia areata (AA) is an autoimmune disease that causes hair loss due to the body’s immune system attacking hair follicles. Although various treatments are currently used for Alopecia areata, herbal remedies have gained prominence due to the increasing interest of patients in natural products. This study aims to examine the efficacy and applicability of plants with therapeutic potential in the treatment of Alopecia areata. Result and Discussion: In recent years, the use of natural plant extracts in the treatment of Alopecia Areata has gained to significant attention. Many of the plants discussed in this study have anti-inflammatory and immunomodulatory properties, making them potentially beneficial in the treatment of Alopecia areata. Additionally, herbal products promote hair growth through mechanisms, such as stimulating cell proliferation in hair follicles, improving blood circulation in the scalp, inhibiting the 5α-reductase enzyme, inducing the release of growth factors, and reducing the levels of inflammatory cytokines. However, further research is required to elucidate the mechanisms of action of some of these plants.

Özet

Amaç: Alopesi areata (AA), vücut bağışıklık sisteminin saç foliküllerine saldırması sonucu saç kaybına neden olan otoimmün bir hastalıktır. Günümüzde Alopesi areatanın tedavisinde çeşitli yöntemler kullanılmakta, ancak hastaların doğal ürünlere olan ilgisinin artması nedeniyle bitkisel tedavi yöntemleri ön plana çıkmaktadır. Bu çalışmada, Alopesi areata tedavisinde terapötik potansiyele sahip bitki türlerinin etkinliğinin ve uygulanabilirliğinin incelenmesi amaçlanmıştır. Sonuç ve Tartışma: Alopesi areata tedavisinde doğal bitki ekstrelerinin kullanımı, son yıllarda önemli bir ilgi odağı haline gelmiştir. Çalışmada ele alınan bitkilerin birçoğu, anti-enflamatuvar ve immünomodülatör özellikleri ile alopesi areata tedavisinde potansiyel faydalar sağlayabilecek niteliktedir. Ayrıca, bitkisel ürünler, saç foliküllerindeki hücrelerin çoğalmasını teşvik etmek, saç derisindeki kan dolaşımını artırmak, 5α-redüktaz enzimini inhibe etmek, büyüme faktörlerinin salınımını tetiklemek veya enflamatuvar sitokinlerin seviyesini düşürmek gibi çeşitli mekanizmalarla saç büyümesinin teşvik edilmesine katkıda bulunmaktadır. Bunun yanında, bazı bitkilerin etki mekanizmasının aydınlatılması için daha fazla çalışma gereklidir.

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Cite This Article

Serbetcı, T., İbrahim, H. B. (2025). EXAMINATION OF SOME POTENTIAL MEDICINAL PLANT SPECIES IN THE TREATMENT OF ALOPECIA AREATA. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, Cilt: 49 Sayı: 3, 940–962. https://doi.org/10.33483/jfpau.1537612

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References (129)

  1. Singh, K., Saeed, F., Ahmad, Z., Ahsan, F., Shakya, P. (2016). Alopecia: Introduction and overview of herbal treatment. Journal of Chemical and Pharmaceutical Research, 8(8), 59-64.
  2. Trüeb, R.M., Dias, M.F.R.G. (2018). Alopecia Areata: A comprehensive review of pathogenesis and management. Clinical Reviews in Allergy & Immunology, 54(1), 68-87. [CrossRef]
  3. Strazzulla, L.C., Wang, E.H.C., Avila, L., Lo Sicco, K., Brinster, N., Christiano, A.M., Shapiro, J. (2018). Alopecia areata: Disease characteristics, clinical evaluation, and new perspectives on pathogenesis. Journal of the American Academy of Dermatology, 78(1), 1-12. [CrossRef]
  4. Whiting, D.A. (1995). Histopathology of alopecia areata in horizontal sections of scalp biopsies. The Journal of Investigative Dermatology, 104(5 Suppl), 26-27. [CrossRef]
  5. Sperling, L.C., Lupton, G.P. (1995). Histopathology of non-scarring alopecia. Journal of Cutaneous Pathology, 22(2), 97-114. [CrossRef]
  6. Papadopoulos, A.J., Schwartz, R.A., Janniger, C.K. (2000). Alopecia areata. Pathogenesis, Diagnosis, and Therapy. American Journal of Clinical Dermatology, 1(2), 101-105. [CrossRef]
  7. Hoover, E., Alhajj, M., Flores, J.L. (2023). Physiology, Hair. [Updated 2023 Jul 30]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; January 2023. Available from: https://www.ncbi.nlm.nih.gov/books/NBK499948/.
  8. Jain, P., Das, D., Das, C. (2017). Prospect of Herbs As Hair Growth Potential. International Journal of Pharmacy and Pharmaceutical Sciences, 5(1), 25-33.
  9. Morgan, B.A. (2014). The dermal papilla: An instructive niche for epithelial stem and progenitor cells in development and regeneration of the hair follicle. Cold Spring Harbor Perspectives in Medicine, 4(7), a015180. [CrossRef]
  10. Murphrey, M.B., Agarwal, S., Zito, P.M. (2023). Anatomy, Hair. [Updated 2023 Aug 14]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; January 2025. Available from: https://www.ncbi.nlm.nih.gov/books/NBK513312/.
  11. Wortsman, X. (2018). Normal Ultrasound Anatomy of the Skin, Nail, and Hair. In: Atlas of Dermatologic Ultrasound. Springer, Cham, 1-22. [CrossRef]
  12. Natarelli, N., Gahoonia, N., Sivamani, R.K. (2023). Integrative and mechanistic approach to the hair growth cycle and hair loss. Journal of Clinical Medicine, 12(3), 893. [CrossRef]
  13. Village dermatology web site. Retrieved February 20, 2024 from https://www.villagedermatologyhouston.com/hair-growth-cycle.
  14. Olsen, E.A. (1994) Androgenetic Alopecia. In: Disorders of Hair Growth: Diagnosis and Treatment, (pp. 87-257). New York: McGraw Hill.
  15. Lu, W., Shapiro, J., Yu, M., Barekatain, A., Lo, B., Finner, A., McElwee, K. (2006). Alopecia areata: Pathogenesis and potential for therapy. Expert Reviews in Molecular Medicine, 8(14), 1-19. [CrossRef]
  16. Shapiro, J. (2013). Current treatment of alopecia areata. The Journal of Investigative Dermatology. Symposium Proceedings, 16(1), 42–44.[CrossRef]
  17. Dahabreh, D., Jung, S., Renert-Yuval, Y., Bar, J., Del Duca, E., Guttman-Yassky, E. (2023). Alopecia areata: Current treatments and new directions. American Journal of Clinical Dermatology, 24(6), 895-912. [CrossRef]
  18. Khan, S., Jameel, M., Kanwal, S., Shahid, S. (2017). Medicinal importance of Allium species: A current review. International Journal of Pharmaceutical Science and Research, 2(3), 29-39.
  19. El-Saber Batiha, G., Magdy Beshbishy, A., G Wasef, L., Elewa, Y.H.A., A Al-Sagan, A., Abd El-Hack, M.E., Taha, A.E., M Abd-Elhakim, Y., Prasad Devkota, H. (2020). Chemical constituents and pharmacological activities of Garlic (Allium sativum L.): A review. Nutrients, 12(3), 872. [CrossRef]
  20. Okoro, B.C., Dokunmu, T.M., Okafor, E., Sokoya, I.A., Israel, E.N., Olusegun, D.O., Bella-Omunagbe, M., Ebubechi, U.M., Ugbogu, E.A., Iweala, E.E.J., (2023). The ethnobotanical, bioactive compounds, pharmacological activities and toxicological evaluation. of garlic (Allium sativum): A review. Pharmacological Research – Modern Chinese Medicine, 8, pages 100273, ISSN 2667-1425. [CrossRef]
  21. Slusarenko, A.J., Patel, A., Portz, D. (2008). Control of plant diseases by natural products: Allicin from garlic as a case study. European Journal of Plant Pathology, 121, 313-322. [CrossRef]
  22. Rahman, M.S. (2007). Allicin and other functional active components in garlic: Health benefits and bioavailability. International Journal of Food Properties, 10(2), 245–268. [CrossRef]
  23. Kaye, A.D., De Witt, B.J., Anwar, M., Smith, D.E., Feng, C.J., Kadowitz, P.J., Nossaman, B.D. (2000). Analysis of responses of garlic derivatives in the pulmonary vascular bed of the rat. Journal of Applied Physiology, 89(1), 353-358. [CrossRef]
  24. National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 65036, Allicin. Retrieved April 17, 2024 from https://pubchem.ncbi.nlm.nih.gov/compound/Allicin.
  25. Maluki, A.H.; Mahmood, T.A.; Hadi, Q.N. (2009). Treatment of alopecia areata with topical garlic extract. Kufa Medical Journal, 12-16.
  26. Hajheydari, Z., Jamshidi, M., Akbari, J., Mohammadpour, R. (2007). Combination of topical garlic gel and betamethasone valerate cream in the treatment of localized alopecia areata: A double-blind randomized controlled study. Indian Journal of Dermatology, Venereology and Leprology, 73(1), 29-32. [CrossRef]
  27. Choudhary, S., Noor, M.U., Hussain, M.S., Mishra, M., Tyagi, S. (2022). Pharmacological properties and phytoconstituents of garlic (Allium sativum L.): Review. Biological Sciences, 2(4), 338-346. [CrossRef]
  28. Stan, S.D., Singh, S.V. (2009). Transcriptional repression and inhibition of nuclear translocation of androgen receptor by diallyl trisulfide in human prostate cancer cells. Clinical Cancer Research, 15(15),4895-4903. [CrossRef]
  29. Inan Yuksel, E., Cicek, D., Demir, B., Sahin, K., Tuzcu, M., Orhan, C., Ozercan, I. H., Sahin, F., Kocak, P.,Yildirim, M. (2023). Garlic exosomes promote hair growth through the Wnt/β-catenin pathway and growth factors. Cureus, 15(7), e42142 [CrossRef]
  30. Shirohiwala, R., Upadhyay, S., Upadhyay, U. (2022). Alopecia therapy: A systemic review on herbal oils used for the treatment of hair loss. International Journal of Enhanced Research in Medicines and Dental Care, 9(3), 2349-1590.
  31. Chang, T.C., Chang, H.T., Chang, S.T., Lin, S.F., Chang, Y.H., Jang, H.D. (2013). A comparative study on the total antioxidant and antimicrobial potentials of ethanolic extracts from various organ tissues of Allium spp. Food and Nutrition Sciences. 04(08),182-190. [CrossRef]
  32. Yousufi, M. (2012). To study antibacterial activity of Allium sativum, Zingiber officinale and Allium cepa by Kirby-Bauer Method. IOSR Journal of Pharmacy and Biological Sciences, 4(5), 6-8. [CrossRef]
  33. Elattar, M.M., Darwish, R.S., Hammoda, H.M., Dawood, H.M. (2024). An ethnopharmacological, phytochemical, and pharmacological overview of onion (Allium cepa L.). Journal of Ethnopharmacology, 324, 117779. [CrossRef]
  34. Marefati, N., Ghorani, V., Shakeri, F., Boskabady, M., Kianian, F., Rezaee, R., Boskabady, M.H. (2021). A review of anti-inflammatory, antioxidant, and immunomodulatory effects of Allium cepa and its main constituents. Pharmaceutical Biology., 59(1), 287-302. [CrossRef]
  35. Sharquie, K.E., Al-Obaidi, H.K. (2002). Onion juice (Allium cepa L.), a new topical treatment for alopecia areata. The Journal of Dermatology, 29(6), 343–346. [CrossRef]
  36. Singh, R., Tripathi, S., Gupta, D., Pujari, N. (2022). Evaluation of pharmacognostical properties and hair growth promoting activity of Allium cepa. Journal of Pharmaceutical Negative Results. 13(S08).
  37. Khristi, V., Patel, V.H. (2016) Therapeutic potential of Hibiscus rosa sinensis: A review. International Journal of Nutrition and Dietetics, 4(2), 105-123. [CrossRef]
  38. Al-Snafi, A.E. (2018). Chemical constituents, pharmacological effects and therapeutic importance of Hibiscus rosa-sinensis-A review. IOSR Journal of Pharmacy 8 (7), 101-119, 2018.
  39. Mishra, N., Tandon, V.L., Gupta, R. (2012). Immunomodulation by Hibiscus rosa-sinensis: Effect on the humoral and cellular immune response of Mus musculus. Pakistan Journal of Biological Sciences: PJBS, 15(6), 277-283. [CrossRef]
  40. Afiune, L.A.F., Leal-Silva, T., Sinzato, Y.K., Moraes-Souza, R.Q., Soares, T.S., Campos, K.E., Fujiwara, R.T., Herrera, E., Damasceno, D.C., Volpato, G.T. (2017). Beneficial effects of Hibiscus rosa-sinensis L. flower aqueous extract in pregnant rats with diabetes. PloS One, 12(6), e0179785. [CrossRef]
  41. Che Rose, L., Syahirah Rusdi, N.N., Asari, A., Effendy Abd Wahid, M., Suhaimi, H. (2020). Potential hair growth of Crude extract from Hibiscus rosa-sinensis Linn. Archives of Pharmacy Practice, 11(4), 13-9.
  42. Pariyar, R. (2015). Evaluation of hair growth promoting and antifungal activity of maharanga bicolor. Journal of Health and Allied Sciences, 5(1): 34-38. [CrossRef]
  43. Visuvanathan, T., Than, L.T.L., Stanslas, J., Chew, S.Y., Vellasamy, S. (2022). Revisiting Trigonella foenum-graecum L.: Pharmacology and therapeutic potentialities. Plants (Basel, Switzerland), 11(11), 1450. [CrossRef]
  44. Bahmani, M., Shirzad, H., Mirhosseini, M., Mesripour, A., Rafieian-Kopaei, M. (2016). A review on ethnobotanical and therapeutic uses of fenugreek (Trigonella foenum-graceum L). Journal of Evidence-Based Complementary and Alternative Medicine, 21(1), 53-62. [CrossRef]
  45. Rajasekaran, A., Priyadharshini, R. (2012). Pharmacognostic evaluation of Trigonella foenum graceum L. leaf and stem. International Journal of Pharmacy and Pharmaceutical Sciences. 4 (5), 99-102.
  46. Imtiaz, F., Islam, M., Saeed, H., Saleem, B., Asghar, M., Saleem, Z. (2017). Impact of Trigonella foenum-graecum leaves extract on mice hair growth. Pakistan Journal of Zoology. 49(4), 1405-1412. [CrossRef]
  47. Gupta, P., Chauhan, N.S., Pathak, A. (2013). Effect of Trigonella foenum-graecum Linn. (seeds) and Butea monosperma Lam. (flowers) on chemotherapy-induced alopecia. Complementary Medicine and Drug Discovery. 3(3), 121-125. [CrossRef]
  48. National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 5570, Trigonelline. Retrieved April 21, 2024 from https://pubchem.ncbi.nlm.nih.gov/compound/Trigonelline.
  49. Lim, C.E., Lee, S.C., So, S., Han, S.M., Choi, J.E., Lee, B.Y. (2018). The complete chloroplast genome sequence of Asarum sieboldii Miq. (Aristolochiaceae), a medicinal plant in Korea. Mitochondrial DNA. Part B, Resources, 3(1), 118-119. [CrossRef]
  50. Zhou, R.H. (1993). Resource science of Chinese medicinal materials. Beijing: China Medical & Pharmaceutical Sciences Press, p. 202—211. Available from: https://scholar.google.com/scholar_lookup?title=Resource+Science+of+Chinese+Medicinal+Materials& author=RH+Zhou&publication_year=1993&.
  51. Han, Y., Kwon, E.H., Kim, S.J. (2003). Protection of brain cells against AMPA-induced damage by Asiasari radix extracts. Phytotherapy Research,17, 882-6. [CrossRef]
  52. Jeong, M., Kim, H.M., Lee, J.S., Choi, J.H., Jang, D.S. (2018). (-)-Asarinin from the roots of Asarum sieboldii induces apoptotic cell death via caspase activation in human ovarian cancer cells. Molecules (Basel, Switzerland), 23(8), 1849. [CrossRef]
  53. Rho, S.S., Park, S.J., Hwang, S.L., Lee, M.H., Kim, C.D., Lee, I.H., Chang, S.Y., Rang, M.J. (2005). The hair growth promoting effect of Asiasari radix extract and its molecular regulation. Journal of Dermatological Science, 38(2), 89-97. [CrossRef]
  54. Insanu, M., Karimah, H., Pramastya, H. Fidrianny, I. (2021). Phytochemical compounds and pharmacological activities of Vitis vinifera L.: An updated review. Biointerface Research in Applied Chemistry, 11(6), 13829-13849. [CrossRef]
  55. Majoul, T., Bouabdallah, F., Majdi, H., Satouri, H., Olfa, T., Slimene, I., Elkahoui, S., Limam, F., Aouani, E. (2019). Chemical composition and biological activities of seeds from four Vitis vinifera tunisian varieties. Journal of Food Chemistry and Nutrition, 7(1). [CrossRef]
  56. Hassan, H., Mahmoud, M. Mahmoud, H. (2015). Chemical studies and phytochemical screening of Grape seeds (Vitis vinifera L.). Minia Journal of Agricultural Research and Development, 35(2), 314-325.
  57. Yarovaya, L., Khunkitti, W. (2023). Grape skin and seed extracts as a potential natural solution for hair loss: A bioactivity evaluation. Songklanakarin Journal of Science and Technology. 45(5), 578-584.
  58. Takahashi, T., Kamiya, T., Hasegawa, A., Yokoo, Y. (1999). Procyanidin oligomers selectively and intensively promote proliferation of mouse hair epithelial cells in vitro and activate hair follicle growth in vivo. Journal of Investigative Dermatology, 112(3), 310-316. [CrossRef]
  59. National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 65064, Epigallocatechin Gallate. Retrieved April 17, 2024 from https://pubchem.ncbi.nlm.nih.gov/compound/Epi gallocatechin-Gallate.
  60. He, X., Fang, J., Huang, L., Wang, J., Huang, X. (2015). Sophora flavescens Ait.: Traditional usage, phytochemistry and pharmacology of an important traditional Chinese medicine. Journal of Ethnopharmacology, 172, 10-29. [CrossRef]
  61. Martins, M.L., Jeronimo, G.T., Figueredo, A.B., Tancredo, K.R., Bertaglia, E.A., Furtado, W.E., Lehmann, N.B., Azevedo, P.F.O., Mourino, J.L.P. (2020). Antiparasitic agents. F.S.B. Kibenge, B. Baldisserotto and R.S. Chong (Eds.). Aquaculture Pharmacology, (Pages 169-217). Florianoplis: Elsevier Science. ISBN 9780128213391. [CrossRef]
  62. Roh, S.S., Kim, C.D., Lee, M.H., Hwang, S.L., Rang, M.J., Yoon, Y.K. (2002). The hair growth promoting effect of Sophora flavescens extract and its molecular regulation. Journal of Dermatological Science, 30(1), 43-49. [CrossRef]
  63. Takahashi, T., Ishino, A., Arai, T., Hamada, C., Nakazawa, Y., Iwabuchi, T., Tajima, M. (2016). Improvement of androgenetic alopecia with topical Sophora flavescens aiton extract, and identification of the two active compounds in the extract that stimulate proliferation of human hair keratinocytes. Clinical and Experimental Dermatology, 41(3), 302-307. [CrossRef]
  64. Cheng, X., Qin, M., Chen, R., Jia, Y., Zhu, Q., Chen, G., Wang, A., Ling, B., Rong, W. 2023). Citrullus colocynthis (L.) Schrad.: A promising pharmaceutical resource for multiple diseases. Molecules (Basel, Switzerland), 28(17), 6221. [CrossRef]
  65. Patel, S., Sharma, V., Chauhan, N.S., Thakur, M., Dixit, V.K. (2015). Hair growth: Focus on herbal therapeutic agent. Current Drug Discovery Technologies, 12(1), 21-42. [CrossRef]
  66. Roy, R.K., Thakur, M., Dixit, V.K. (2007). Development and evaluation of polyherbal formulation for hair growth-promoting activity. Journal of Cosmetic Dermatology, 6(2), 108-112. [CrossRef]
  67. Li, Q.Y., Munawar, M., Saeed, M., Shen, J.Q., Khan, M.S., Noreen, S., Alagawany, M., Naveed, M., Madni, A., Li, C.X. (2022). Citrullus colocynthis (L.) Schrad (Bitter Apple Fruit): Promising traditional uses, pharmacological effects, aspects, and potential applications. Frontiers in Pharmacology, 12, 791049. [CrossRef]
  68. Roy, R.K., Thakur, M., Dixit, V.K. (2007). Effect of Citrullus colocynthis on hair growth in albino rats. Pharmaceutical Biology, 45:10, 739-744. [CrossRef]
  69. Yu, J.Y., Gupta, B., Park, H.G., Son, M., Jun, J.H., Yong, C.S., Kim, J.A., Kim, J.O. (2017). Preclinical and clinical studies demonstrate that the proprietary herbal extract DA-5512 effectively stimulates hair growth and promotes hair health. Evidence-based Complementary and Alternative Medicine: eCAM, 4395638. [CrossRef]
  70. Gaire, B.P., Subedi, L. (2014). Phytochemistry, pharmacology and medicinal properties of Phyllanthus emblica Linn. Chinese Journal Of Integrative Medicine. [CrossRef]
  71. Krishnaveni, M., Mirunalini, S. (2010). Therapeutic potential of Phyllanthus emblica (amla): The ayurvedic wonder. Journal of Basic and Clinical Physiology and Pharmacology, 21(1), 93-105. [CrossRef]
  72. Purwal, L., Gupta, S.P., Pande, M.S. (2008). Development and evaluation of herbal formulations for hair growth. Journal of Chemistry, 5(1), 34-38. [CrossRef]
  73. Nikki Nina, B., Charmaine Pearl, C., Ishan, D., Patricia, T.I.I., Sree, M., Neil Aldrin, P. (2023). Hair growth-promoting effects of Phyllanthus emblica (Indian gooseberry) oil in human subjects with alopecia in Cebu City, Philippines. Figshare. Thesis. [CrossRef]
  74. Timalsina, D., Devkota, H.P. (2021). Eclipta prostrata (L.) L. (Asteraceae): Ethnomedicinal uses, chemical constituents, and biological activities. Biomolecules, 11(11), 1738. [CrossRef]
  75. Roy, R.K., Thakur, M., Dixit, V.K. (2008). Hair growth promoting activity of Eclipta alba in male albino rats. Archives of Dermatological Research, 300(7), 357-364. [CrossRef]
  76. Chokotia, L.S., Vashistha, P., Sironiya, R., Matoli, H. (2013). Pharmacological activities of Eclipta alba (L.). International Journal of Research and Development in Pharmacy and Life Sciences, 2(4), 499-502. [CrossRef]
  77. Jahan, R., Al-Nahain, A., Majumder, S., Rahmatullah, M. (2014). Ethnopharmacological significance of Eclipta alba (L.) Hassk. (Asteraceae). International Scholarly Research Notices, 385969. [CrossRef]
  78. Begum, S., Lee, M.R., Gu, L.J., Hossain, M.J., Kim, H.K., Sung, C.K. (2014). Comparative hair restorer efficacy of medicinal herb on nude (Foxn1nu) mice. BioMed Research International, 319795. [CrossRef]
  79. Datta, K., Singh, A.T., Mukherjee, A., Bhat, B., Ramesh, B., Burman, A.C. (2009). Eclipta alba extract with potential for hair growth promoting activity. Journal of Ethnopharmacology, 124(3), 450-456. [CrossRef]
  80. Paus, R., Müller-Röver, S., Van Der Veen, C., Maurer, M., Eichmüller, S., Ling, G., Hofmann, U., Foitzik, K., Mecklenburg, L., Handjiski, B. (1999). A comprehensive guide for the recognition and classification of distinct stages of hair follicle morphogen. morphogenesis. The Journal of Investigative Dermatology, 113(4), 523-532. [CrossRef]
  81. National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 5281813, Wedelolactone. Retrieved April 18, 2024 from https://pubchem.ncbi.nlm.nih.gov/compound/Wedelo lactone.
  82. Mechqoq, H., El Yaagoubi, M., El Hamdaoui, A., Momchilova, S., Guedes da Silva Almeida, J. R., Msanda, F., El Aouad, N. (2021). Ethnobotany, phytochemistry and biological properties of Argan tree (Argania spinosa (L.) Skeels) (Sapotaceae)-A review. Journal of Ethnopharmacology, 281, 114528. [CrossRef]
  83. Charrouf, Z., Guillaume, D. (2008). Argan oil: Occurrence, composition and impact on human health. European Journal of Lipid Science and Technology. 110, 632–636. [CrossRef]
  84. Goto, M., Kuda, T., Shikano, A., Takahashi, H., Kimura, B. (2021). Effects of ethanol-precipitated argan press cake on the caecal microbiome of mice fed a high-sucrose diet. Waste and Biomass Valorization, 12, 1-10. [CrossRef]
  85. Charrouf, Z., Guillaume, D. (1999). Ethnoeconomical, ethnomedical, and phytochemical study of Argania spinosa (L.) Skeels. Journal of Ethnopharmacology, 67(1), 7–14. [CrossRef]
  86. Khallouki, F., Eddouks, M., Mourad, A., Breuer, A., Owen, R.W. (2017). Ethnobotanic, ethnopharmacologic aspects and new phytochemical ınsights into moroccan argan fruits. International Journal of Molecular Sciences, 18(11), 2277. [CrossRef]
  87. Bourhim, T., Villareal, M.O., Gadhi, C., Hafidi, A., Isoda, H. (2018). Depigmenting effect of argan press-cake extract through the down-regulation of Mitf and melanogenic enzymes expression in B16 murine melanoma cells. Cytotechnology, 70(5), 1389-1397. [CrossRef]
  88. Bejaoui, M., Taarji, N., Saito, M., Nakajima, M., Isoda, H. (2021). Argan (Argania Spinosa) press cake extract enhances cell proliferation and prevents oxidative stress and inflammation of human dermal papilla cells. Journal of Dermatological Science. [CrossRef]
  89. Liu, Y., Xin, H., Zhang, Y., Che, F., Shen, N., Cui, Y. (2022). Leaves, seeds and exocarp of Ginkgo biloba L. (Ginkgoaceae): A comprehensive review of traditional uses, phytochemistry, pharmacology, resource utilization and toxicity. Journal of Ethnopharmacology, 298, 115645. [CrossRef]
  90. Chan, P.C., Xia, Q., Fu, P.P. (2007). Ginkgo biloba leave extract: Biological, medicinal, and toxicological effects. Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis and Ecotoxicology Reviews, 25(3), 211-244. [CrossRef]
  91. Kobayashi, N., Suzuki, R., Koide, C., Suzuki, T., Matsuda, H., Kubo, M. (1993). Effect of leaves of Ginkgo biloba on hair regrowth in C3H strain mice. Yakugaku zasshi: Journal of the Pharmaceutical Society of Japan, 113(10), 718-724. [CrossRef]
  92. Li, Y., Sheng, Y., Liu, J., Xu, G., Yu, W., Cui, Q., Lu, X., Du, P., An, L. (2022). Hair-growth promoting effect and anti-inflammatory mechanism of Ginkgo biloba polysaccharides. Carbohydrate Polymers, 278, 118811. [CrossRef]
  93. Cho, J.H., Kwon, J.E., Cho, Y., Kim, I., Kang, S.C. (2015). Anti-inflammatory effect of Angelica gigas via heme oxygenase (HO)-1 expression. Nutrients, 7(6), 4862–4874. [CrossRef]
  94. He, L., Pan, Y., Yu, J., Wang, B., Dai, G., Ying, X. (2021). Decursin alleviates the aggravation of osteoarthritis via inhibiting PI3K-Akt and NF-kB signal pathway. International Immunopharmacology, 97, 107657. [CrossRef]
  95. Kim, M.H., Choi, Y.Y., Cho, I.H., Hong, J., Kim, S.H., Yang, W.M. (2014). Angelica sinensis induces hair regrowth via the inhibition of apoptosis signaling. The American journal of Chinese medicine, 42(4), 1021–1034. [CrossRef]
  96. Lee, T.K., Kim, B., Kim, D.W., Ahn, J.H., Sim, H., Lee, J.C., Yang, G.E., Her, Y., Park, J.H., Kim, H.S., Sim, T.H., Lee, H.S., Won, M.H. (2020). Effects of decursin and angelica gigas nakai root extract on hair growth in mouse dorsal skin via regulating inflammatory cytokines. Molecules (Basel, Switzerland), 25(16), 3697. [CrossRef]
  97. National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 442126, Decursin. Retrieved April 18, 2024 from https://pubchem.ncbi.nlm.nih.gov/compound/Decursin.
  98. Aziz, E., Batool, R., Akhtar, W., Shahzad, T., Malik, A., Shah, M.A., Iqbal, S., Rauf, A., Zengin, G., Bouyahya, A., Rebezov, M., Dutta, N., Khan, M.U., Khayrullin, M., Babaeva, M., Goncharov, A., Shariati, M.A., Thiruvengadam, M. (2022). Rosemary species: A review of phytochemicals, bioactivities and industrial applications. South African Journal of Botany, 151, 3-18 [CrossRef]
  99. Murata, K., Noguchi, K., Kondo, M., Onishi, M., Watanabe, N., Okamura, K., Matsuda, H. (2012). Promotion of hair growth by Rosmarinus officinalis leaf extract. Phytotherapy Research, 27(2), 212-217. [CrossRef]
  100. Luziani, S., Darwinata, A.E., Praharsini, I.G.A.A., Wijaya, V.O. (2023). Rosmarinus officinalis essential oil increases hair length and follicle diameter of ultraviolet B-exposed mice through VEGF. The Indonesian Biomedical Journal, 15(4), 347-353. [CrossRef]
  101. Ulbricht, C., Abrams, T.R., Brigham, A., Ceurvels, J., Clubb, J., Curtiss, W., Kirkwood, C.D., Giese, N., Hoehn, K., Iovin, R., Isaac, R., Rusie, E., Serrano, J.M.G., Varghese, M., Weissner, W., Windsor, R.C. (2010). An evidence-based systematic review of rosemary (Rosmarinus officinalis) by the Natural Standard Research Collaboration. Journal of Dietary Supplements, 7(4), 351-413. [CrossRef]
  102. Hajhashemi, V., Ghannadi, A., Sharif, B. (2003). Anti-inflammatory and analgesic properties of the leaf extracts and essential oil of Lavandula angustifolia Mill. Journal of Ethnopharmacology, 89(1), 67-71. [CrossRef]
  103. López, V., Nielsen, B., Solas, M., Ramírez, M.J., Jäger, A.K. (2017). Exploring pharmacological mechanisms of lavender (Lavandula angustifolia) essential oil on central nervous system targets. Frontiers in Pharmacology, 8. [CrossRef]
  104. Prusinowska, R., Åšmigielski, K. (2014). Composition, biological properties and therapeutic effects of lavender (Lavandula angustifolia L): A review. Herba Polonica, 60.
  105. Lee, B.H., Lee, J.S., Kim, Y.C. (2016). Hair growth-promoting effects of lavender oil in C57BL/6 Mice. Toxicological Research, 32(2), 103-108. [CrossRef]
  106. Hay, I.C., Jamieson, M., Ormerod, A.D. (1998). Randomized trial of aromatherapy. Successful treatment for alopecia areata. Archives of Dermatology, 134(11), 1349-1352.[CrossRef]
  107. Ozmen, I., Calıskan, E., Arca, E., Acikgoz, G., Koc, E. (2015). Efficacy of aromatherapy in the treatment of localized alopecia areata: A double-blind placebo controlled study. Gulhane Medical Journal, 57(3), 233. [CrossRef]
  108. Muntyanu, A., Gabrielli, S., Donovan, J., Gooderham, M., Guenther, L., Hanna, S., Lynde, C., Prajapati, V.H., Wiseman, M., Netchiporouk, E. (2023). The burden of alopecia areata: A scoping review focusing on quality of life, mental health and work productivity. Journal of the European Academy of Dermatology and Venereology, 37(8), 1490-1520. [CrossRef]
  109. Toussi, A., Barton, V.R., Le, S.T., Agbai, O.N., Kiuru, M. (2021). Psychosocial and psychiatric comorbidities and health-related quality of life in alopecia areata: A systematic review. Journal of the American Academy of Dermatology, 85(1), 162-175. [CrossRef]
  110. Zeberkiewicz, M., Rudnicka, L., Malejczyk, J. (2020). Immunology of alopecia areata. Central European Journal of Immunology, 45(3), 325-333. [CrossRef]
  111. Lintzeri, D.A., Constantinou, A., Hillmann, K., Ghoreschi, K., Vogt, A., Blume‐Peytavi, U. (2022). Alopecia areata-Current understanding and management. JDDG: Journal Der Deutschen Dermatologischen Gesellschaft, 20(1), 59-90. Portico. [CrossRef]
  112. Ruchiatan, K., Avriyanti, E., Hindritiani, R., Puspitosari, D., Suwarsa, O., Gunawan, H. (2022). Successful therapy of alopecia universalis using a combination of systemic methotrexate and corticosteroids and topical 5% Minoxidil. Clinical, Cosmetic and Investigational Dermatology, Volume 15, 127-132. [CrossRef]
  113. Yorulmaz, A. (2016). Androgenetik alopesi. Journal of Contemporary Medicine, 6(3). [CrossRef]
  114. Chairerg, P., Asawanonda, P., Kongkabpan, M. (2012). The use of sulfasalazine in severe types of alopecia areata. Hair: Therapy, Transplantation, 01(01). [CrossRef]
  115. Renert-Yuval, Y., Guttman-Yassky, E. (2017). The changing landscape of alopecia areata: The therapeutic paradigm. Advances in Therapy, 34(7), 1594-1609. [CrossRef]
  116. Mahasaksiri, T., Kositkuljorn, C., Anuntrangsee, T., Suchonwanit, P. (2021). Application of topical immunotherapy in the treatment of alopecia areata: A review and update. Drug Design, Development and Therapy, Volume 15, 1285-1298. [CrossRef]
  117. Freire, P.C.B., Riera, R., Martimbianco, A.L.C., Petri, V., Atallah, A.N. (2019). Minoxidil for patchy alopecia areata: Systematic review and meta‐analysis. Journal of the European Academy of Dermatology and Venereology, 33(9), 1792-1799. [CrossRef]
  118. Barbareschi, M. (2018). The use of minoxidil in the treatment of male and female androgenetic alopecia: A story of more than 30 years. Italian Journal of Dermatology and Venereology, 153(1). [CrossRef]
  119. Lachgar, S., Charveron, M., Gall, Y., Bonafe, J.L. (1998). Minoxidil upregulates the expression of vascular endothelial growth factor in human hair dermal papilla cells. British Journal of Dermatology, 138(3), 407-411. Portico. [CrossRef]
  120. Dallob, A.L. (1994). The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness. Journal of Clinical Endocrinology and Metabolism, 79(3), 703-706. [CrossRef]
  121. Temiz, S.A., Durdu, M. (2023). Saç Dökülmesinde Difensipron Tedavisi. Kartal SP, Editör. Dermatoloji - Güncel. 1. Baskı. Ankara: Türkiye Klinikleri, p.144-148.
  122. Tkachenko, E., Okhovat, J.P., Manjaly, P., Huang, K.P., Senna, M.M., Mostaghimi, A. (2023). Complementary and alternative medicine for alopecia areata: A systematic review. Journal of the American Academy of Dermatology, 88(1), 131-143. [CrossRef]
  123. Ehsani, A., Toosi, S., Seirafi, H., Akhyani, M., Hosseini, M., Azadi, R., Noormohamadpour, P., Ghanadan, A. (2009). Capsaicin vs. clobetasol for the treatment of localized alopecia areata. Journal of the European Academy of Dermatology and Venereology, 23(12), 1451-1453. [CrossRef]
  124. Choi, J.Y., Boo, M.Y., Boo, Y.C. (2024). Can plant extracts help prevent hair loss or promote hair growth? A review comparing their therapeutic efficacies, phytochemical components, and modulatory targets. Molecules, 29(10), 2288. [CrossRef]
  125. Galkin, A.Y., Solovjova, V.F., Dugan, A.M. (2013). Anti-inflammatory and immunomodulating properties of the herbal preparation indicated for prevention and treatment of alopecia. Botanics: Targets and Therapy, 49. [CrossRef]
  126. Rusu, M., Csedo, C., Marcus, G., Lupuliasa, D. (2008). Preclinical study on the hair growth and regeneration of external use lotions containing castor oil (Ricini oleum) in rabbits. Farmacia, 56, 507-512.
  127. Kporou, E., Sitapha, O., Moussa, G., Gouedji, Y., Kra, A., Djaman, J. (2021). Quality, safety and activity of an ointment formulated from Butyrospermum parkii and Ricinus communis oils on rabbits hair growth. Rev. RAMReS-Ser. Pharm. Med. Trad. Afr., 20, 38-46
  128. Tiwari, R., Tiwari, G., Yadav, A., Ramachandran, V. (2021). Development and evaluation of herbal hair serum: A traditional way to improve hair quality. The Open Dermatology Journal, 15(1), 52-58. [CrossRef]
  129. Marefati, N., Ghorani, V., Shakeri, F., Boskabady, M., Kianian, F., Rezaee, R., Boskabady, M.H. (2021). A review of anti-inflammatory, antioxidant, and immunomodulatory effects of Allium cepa and its main constituents. Pharmaceutical Biology., 59(1), 287-302. [CrossRef]