Doksazosin'in esansiyel hipertansiyonda antihipertansif, kardiyak ve metabolik etkileri

Antihypertensive, cardiac and metabolic effects of doxazosin in essential hypertension

Özet

Bu çalışmamızda, selektifpostsinaptikCLl-adrenoreseptör blokeri olan doksazosinin hafif ve¬ya orta dereceli esansiyel hipertansiyonlu olguların tedavisindeki yeri ile kardiyak ve metabolik etkilerini araştırmayı amaçladık. Çalışmaya 20'si (%58.8) kadın, 14'ü (%41.1) erkek ve yaş ortalaması 53 ±8.2 yıl olan hafif veya orta dereceli esansiyel hipertansiyonulu 34 olgu alındı. Oniki haftalık doksazosin tedavisi sonrasında hem diastolik kan basıncında (p

Abstract

Antihypertensive, Cardiac and Metabolic Effects of Doxazosin in Essential Hypertension In this study, we aimed to evaluate the effect of doxazosin theraphy (1-4 mg/day) on blood pressure, left ventricular mass, systolic and diastolic functions and metabolic profile in patients with mild or moderate essential hypertension.Thirty-four patients, who were included in the study, were serially studied during 12 weeks with 2 weekly intervals by recording of blood pressures, heart rate, metabolic profile and echo-cardiogram. After 3-month treatment systolic blood pressure and diastolic blood pressure were significantly reduced (p0.05). Doxa-zosin treatment was associated with significant improvement in HDL and apo B (p