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Dergiler / Experimed / 2023 / Cilt: 13 Sayı: 2

Investigation of the Effect of Serum IL-1β Levels on Atherosclerosis: A Turkish Population-Based Study

Dilveen DLAWER OMER
Fatma Tuba AKDENİZ
Seda GÜLEÇ
Zerrin BARUT
Deryanaz BİLLUR
Ayça TÜRER CABBAR
Turgay İSBİR
Sayfa
142–147
Yayın Tarihi
2023-09-18
DOI
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Studies involving different ethnic groups with a large sample and identifying the stages of the disease are necessary to confirm these results.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: Atherosclerosis, as a cardiovascular disease associated with chronic inflammatory conditions and involving a large number of risk factors, harbors a lot of unknowns.
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Temel Bulgular & Veri:It has not been fully elucidated in which stages and how interleukin-1 beta (IL-1β), which is associated with inflammations, plays a role in the chronic inflammatory process of the disease.
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Sonuç & Katkı:Studies involving different ethnic groups with a large sample and identifying the stages of the disease are necessary to confirm these results.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Atherosclerosis · inflammation · IL-1β

Abstract

Objective: Atherosclerosis, as a cardiovascular disease associated with chronic inflammatory conditions and involving a large number of risk factors, harbors a lot of unknowns. Evidence has emerged that almost all stages of the disease are intertwined with inflammation. It has not been fully elucidated in which stages and how interleukin-1 beta (IL-1β), which is associated with inflammations, plays a role in the chronic inflammatory process of the disease. Also, the effect on atherosclerosis progression and biomarker candidacy of IL-1β in the Turkish population is unknown. The aim of this study was to investigate the serum IL-1β expression levels and whether it is associated with changes in risk factors that develop due to the disease in the Turkish population. Materials and Methods: ELISA method was used to analyze the serum IL-1β levels. Statistical data was obtained utilizing the SPSS v.23 software. Results: No linkage evidence was found between the serum IL-1β and atherosclerosis (p>0.05). However, the serum IL-1β levels were significantly associated with gender, smoking status, and diabetes history within the study population were significantly associated (p=0.050). According to the lipid profile result, the triglyceride value was found to be significantly decreased in atherosclerosis patients when compared to healthy individuals (p=0.012). Additionally, factors including, gender, smoking status, and history of diabetes were significantly associated with serum cholesterol level (p=0.015). Conclusion: Although no correlation was found between the serum IL-1β levels of the study groups, it was observed that the serum IL-1β expression alters in patients with atherosclerosis depending on age. In addition, low triglyceride levels may be a marker of disease in atherosclerosis patients. Studies involving different ethnic groups with a large sample and identifying the stages of the disease are necessary to confirm these results.

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Bu Makaleye Atıf Yap

OMER, D. D., AKDENİZ, F. T., GÜLEÇ, S., BARUT, Z., BİLLUR, D., CABBAR, A. T., İSBİR, T. (2023). Investigation of the Effect of Serum IL-1β Levels on Atherosclerosis: A Turkish Population-Based Study. Experimed, Cilt: 13 Sayı: 2, 142–147. https://ajindex.com/articles/962022

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