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Dergiler / Journal of Gazi University Health Sciences Institute / 2023 / Cilt: 5 Sayı: 1

Desflurane Protects The Brain Against The Oxidant Activity of Acute Hyperglycemia in Diabetic Rats, Comparison with Sevoflurane

Alican KAYA
Mustafa ARSLAN
Elif BEŞKARDEŞ
Ömer KURTİPEK
Dilek KALAYCI
Alper Tunga DOGAN
Ayşe Hande ARPACI
Işın GÜNEŞ
Mustafa KAVUTCU
Sayfa
34–41
Yayın Tarihi
2023-04-30
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Since our study is the first study in this field, it should be supported by other studies to be carried out.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:In this study, we investigated the effects of sevoflurane and desflurane administration on the oxidant and antioxidant system in the brain of acute hyperglycemia in diabetic rats.
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Temel Bulgular & Veri:In the study, 30 male Wistar Albino rats were randomly divided into five groups.
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Sonuç & Katkı:Since our study is the first study in this field, it should be supported by other studies to be carried out.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Antioxidant system · Brain · Desflurane

Abstract

In this study, we investigated the effects of sevoflurane and desflurane administration on the oxidant and antioxidant system in the brain of acute hyperglycemia in diabetic rats. In the study, 30 male Wistar Albino rats were randomly divided into five groups. Diabetes was induced by administering a single dose of intraperitoneal streptozotocin (55 mg/kg) to rats except for the control group (C). To create acute hyperglycemia in diabetic groups, which were hyperglycemia (DH), desflurane (D), and sevoflurane (S) groups, 2.5 g/kg glucose was administered intraperitoneally. After glucose administration, desflurane 6% and sevoflurane 2.3% mixed with 4 L/min oxygen were administered for 2 hours, by which minimal alveolar concentration for rats would be one. Afterward, the animals were sacrificed, and their brain tissues were prepared for biochemical analysis. Catalase (CAT), glutathione-s-transferase (GST), paraoxonase (PON) activities, and TBARS levels were measured to determine oxidant and antioxidant status. GST activity was significantly lower in group D than in group DH (p=0.001). The PON activity was significantly lower in the D group compared with other groups (p<0.001). In the S group, PON activity was significantly lower than in the diabetic control (DC) group and DH groups (p=0.022, p=0.020, respectively). TBARS level was significantly lower in group D than in group DH (p=0.013). As a result, desflurane decreases GST and PON activity and TBARS levels more than sevoflurane. In terms of lipid peroxidation, desflurane shows more protective properties than sevoflurane. Since our study is the first study in this field, it should be supported by other studies to be carried out.

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Bu Makaleye Atıf Yap

KAYA, A., ARSLAN, M., BEŞKARDEŞ, E., KURTİPEK, Ö., KALAYCI, D., DOGAN, A. T., ARPACI, A. H., GÜNEŞ, I., KAVUTCU, M. (2023). Desflurane Protects The Brain Against The Oxidant Activity of Acute Hyperglycemia in Diabetic Rats, Comparison with Sevoflurane. Journal of Gazi University Health Sciences Institute, Cilt: 5 Sayı: 1, 34–41. https://ajindex.com/articles/937609

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Kaynakça (10)

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