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Dergiler / İstanbul Journal of Pharmacy / 2023 / Cilt: 53 Sayı: 1

Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract

Umay Merve GÜVEN
Yusuf YAKUT
Nurdan ÇAKIR
Serpil DEMİRCİ KAYIRAN
Sayfa
30–38
Yayın Tarihi
2023-04-28
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: Thermosensitive in-situ gels containing S. ebulus may be a viable alternative for treating fungal diseases.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Background and Aims: Sambucus ebulus L. has been used to treat inflammation-related gastrointestinal disorders, influen- za, kidney ailments, lung diseases, rheumatoid arthritis, and snake and insect bites.
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Temel Bulgular & Veri:Our study provides important ethnobo- tanical information about S. ebulus with the aim of developing a formulation with increased extract bioavailability, diminished side effects, and easy drug loading and dose adjustment as an effective local therapy for dermatologic diseases.
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Sonuç & Katkı:Conclusion: Thermosensitive in-situ gels containing S. ebulus may be a viable alternative for treating fungal diseases.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Sambucus ebulus L. · in-situ gel · gelling system

Abstract

Background and Aims: Sambucus ebulus L. has been used to treat inflammation-related gastrointestinal disorders, influen- za, kidney ailments, lung diseases, rheumatoid arthritis, and snake and insect bites. Our study provides important ethnobo- tanical information about S. ebulus with the aim of developing a formulation with increased extract bioavailability, diminished side effects, and easy drug loading and dose adjustment as an effective local therapy for dermatologic diseases. Methods: Twelve in-situ gels with S. ebulus were prepared as antifungal treatments in accordance with the cold method and formulated using poloxamer and hydroxypropyl methylcellulose (HPMC). The formulations were characterized in terms of pH, gelling capacity, swelling degree, spreadability, and rheological properties. Results: Among the prepared in situ gel formulations, the Poloxamer 407 and 407-HPMC mixtures of P14H1 and P15 demon- strated acceptable gelation temperatures for dermal use. Conclusion: Thermosensitive in-situ gels containing S. ebulus may be a viable alternative for treating fungal diseases.

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Bu Makaleye Atıf Yap

GÜVEN, U. M., YAKUT, Y., ÇAKIR, N., KAYIRAN, S. D. (2023). Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract. İstanbul Journal of Pharmacy, Cilt: 53 Sayı: 1, 30–38. https://ajindex.com/articles/936446

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Kaynakça (12)

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