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Dergiler / Veterinary Journal of Mehmet Akif Ersoy University / 2018 / Cilt: 3 Sayı: 2

Immunohistochemical Determination of the Matrix Metalloproteinase-2 and -7 Expression in Transmissible Venereal Tumor in Dogs

Özlem ÖZMEN
Ezgi OGUS
Sayfa
106–110
Yayın Tarihi
2018-12-30
DOI
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In addition, a positive correlation was determined between the tumor size and immunoexpressions of the markers indicating that both MMP-2 and -7 participate in the TVT pathogenesis.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Transmissible venereal tumor (TVT) is a sexually transmitted, naturally occurring tumor of the canine family and often occurs in tropical and subtropical countries.
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Temel Bulgular & Veri:Both MMP-2 and -7 strongly associated with the invasion and metastasis of different cancer types.
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Sonuç & Katkı:In addition, a positive correlation was determined between the tumor size and immunoexpressions of the markers indicating that both MMP-2 and -7 participate in the TVT pathogenesis.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:dog · pat

Abstract

Transmissible venereal tumor (TVT) is a sexually transmitted, naturally occurring tumor of the canine family and often occurs in tropical and subtropical countries. The matrix metalloproteinases (MMPs) are endogenous proteases accountable for the degradation of extracellular matrix (ECM) components, such as collagen and other proteins including the basement membrane. MMPs play a vital role in the tumor metastasis and angiogenesis. Both MMP-2 and -7 strongly associated with the invasion and metastasis of different cancer types. This study aims to investigate the MMP-2 and -7 expression in naturally occurring TVT in 20 dogs using immunohistochemical methods. Immunohistochemically, we observed increased MMP-2 and -7 expressions in tumor cells. In addition, a positive correlation was determined between the tumor size and immunoexpressions of the markers indicating that both MMP-2 and -7 participate in the TVT pathogenesis.

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Bu Makaleye Atıf Yap

ÖZMEN, Ö., OGUS, E. (2018). Immunohistochemical Determination of the Matrix Metalloproteinase-2 and -7 Expression in Transmissible Venereal Tumor in Dogs. Veterinary Journal of Mehmet Akif Ersoy University, Cilt: 3 Sayı: 2, 106–110. https://ajindex.com/articles/931270

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