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Dergiler / İstanbul Journal of Pharmacy / 2016 / Cilt: 46 - Sayı: 2

Importance of Colchicum species in modern therapy and its significance in Turkey

Gizem Gülsoy Toplan
Çağlayan Gürer
Afife Mat
Sayfa
129–144
Yayın Tarihi
2016-12-26
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

This review was performed to summarize the investigations on Colchicum species in the world and to emphasize its importance in Turkey.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Colchicum species, which are widely used as medication for many years, still remain important in treatment.
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Temel Bulgular & Veri:In our department, Colchicum species have been studied for more than 45 years and the contents and biological activities of the Colchicum species growing in our country are continuing to be studied today.
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Sonuç & Katkı:This review was performed to summarize the investigations on Colchicum species in the world and to emphasize its importance in Turkey.
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Colchicum · tropolone alkaloids · colchicine

Özet

Colchicum species, which are widely used as medication for many years, still remain important in treatment. Some of them are cultivated to be used for pharmaceutical industry. Tropolone alkaloids content of the species help in the treatment of FMF, gout, amyloidosis, cirrhosis, Behcet’s disease, psoriasis, Hodgkin lymphoma, myeloid leukemia and skin cancers. An economic and efficient synthesis method of Colchicum alkaloids haven’t found yet, that’s why colchicine and other alkaloids are obtained from plant source by extraction. The wide variety of Colchicum species in Turkey lead the researchers to investigate new sources of Colchicum rich in tropolone alkaloids. In our department, Colchicum species have been studied for more than 45 years and the contents and biological activities of the Colchicum species growing in our country are continuing to be studied today. This review was performed to summarize the investigations on Colchicum species in the world and to emphasize its importance in Turkey.

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Bu Makaleye Atıf Yap

Toplan, G. G., Gürer, Ç., Mat, A. (2016). Importance of Colchicum species in modern therapy and its significance in Turkey. İstanbul Journal of Pharmacy, Cilt: 46 - Sayı: 2, 129–144. https://ajindex.com/articles/92742

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Kaynakça (17)

  1. Ahern MJ, Reid C, Gordon TP, Mccredie M, Brooks PM, Jones M (1987) Does colchicine work? The results of the first controlled study in acute gout, Australian and New Zealand J of Med., 17: 301-304.
  2. Aisen PS, Marin DB, Brickman AM, Santoro J, Fusco M (2001) Pilot Tolerability Studies of Hydroxychloroquine and Colchicine in Alzheimer Disease, Alzheimer Disease & Associated Disorders 15: 96-101.
  3. Al-Fayyad M, Alali F, Alkofahi A, Tell A (2002) Determination of Colchicine Content in Colchicum Hierosolymitanum and Colchicum Tunicatum Under Cultivation, Nat. Product Lett.,16: 395-400.
  4. Alali FQ, Tawaha K (2007) Determination of (–) -Demecolcine and (–) -Colchicine Content in Selected Jordanian Colchicum Species, Die Pharmazie, 1995: 739-42.
  5. Alali FQ, Gharaibeh AA, Ghawanmeh A, Tawaha K, Qandil A, Burgess JP, Oberlies NH (2010) Colchicinoids from Colchicum crocifolium boiss.(Colchicaceae), Nat. product res., 24: 152-159.
  6. Alali FQ, El-Elimat T, Li C, Qandil A, Alkofahi A, Tawaha K, Falkinham JO (2005) New Colchicinoids from a Native Jordanian Meadow Saffron, Colchicum brachyphyllum: Isolation of the First Naturally Occurring Dextrorotatory Colchicinoid, J Nat Products,, 68: 173-78.
  7. Alexiou S (2013).
  8. The Genus Colchicum in Greece, Parnassiana archives, 1: 59-73.
  9. Baytop T (1999) Türkiye’de Bitkilerle Tedavi, Istanbul, Nobel Tıp Kitabevleri, 81-84.
  10. Baytop T, Özcöbek G (1970) Colchicum chalcedonicum, micranthum, szovitsii ve turcicum Alkaloitleri Üzerinde Araştırmalar. J Fac. Pharm of Istanbul University 6: 21-26.
  11. Ben-Chetrit E, Berkun Y, Ben-Chetrit E, Ben-Chetrit A, (2004) The Outcome of Pregnancy in the Wives of Men with Familial Mediterranean Fever Treated with Colchicine, Seminars in Arthritis and Rheumatism, 34: 549-52.
  12. Ben-Chetrit E, Levy M (1998) Colchicine: 1998 Update Seminars in Arthritis and Rheumatism 28: 48-59.
  13. Borstad GC, Bryant LR, Abel MP, Scroggie DA, Harris MD, Alloway JA (2004) Colchicine for prophylaxis of acute flares when initiating allopurinol for chronic gouty arthritis. J Rheumatol, 31: 2429-2432.
  14. Brossi A (1990) Bioactive Alkaloids. 4. Results of Recent Investigations with Colchicine and Physostigmine J Med Chem 33: 2311-2319.
  15. Cairns HS, Spencer S, Hilson AJ, Rudge CJ, Neild GH (1994) 99mTc-DMSA imaging with tomography in renal transplant recipients with abnormal lower urinary tracts. Nephrol Dial Transpl, 9: 1157-1161.
  16. Capraro HG, Brossi A (1984) Tropolonic Colchicum Alkaloids. The alkaloids 23: 1-70.
  17. Cifuentes M, Schilling B, Ravindra R, Win