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Dergiler / Veterinary Sciences and Practices / 2018 / Cilt: 13 Sayı: 3

Bakır Nefrotoksisitesinde Melatonin ve E Vitamini’nin Antioksidan Parametreler Üzerine Etkileri

The Effects of Melatonin and Vitamin E on Antioxidant Parameters in Copper Nephrotoxicity

Mehmet Ali Temiz(YÜZÜNCÜ YIL ÜNİVERSİTESİ, EĞİTİM FAKÜLTESİ, MATEMATİK VE FEN BİLİMLERİ EĞİTİMİ BÖLÜMÜ)
Atilla Temur(YÜZÜNCÜ YIL ÜNİVERSİTESİ, EĞİTİM FAKÜLTESİ, MATEMATİK VE FEN BİLİMLERİ EĞİTİMİ BÖLÜMÜ)
Sayfa
347–354
Yayın Tarihi
2018-12-25
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Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Sonuç olarak, E vitamini ve melatonin takviyesi antioksidan sistemi güçlendirerek Cu temelli oksidasyonun engellenmesini sağlayabilir.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Bakır (Cu) bileşikleri özellikle endüstri ve tarımda geniş kullanım alanına sahiptir.
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Temel Bulgular & Veri:İz miktardaki Cu hayatın sürdürülebilir olması için gerekliyken fazlası organizma için toksik etki yapmaktadır.
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Sonuç & Katkı:Sonuç olarak, E vitamini ve melatonin takviyesi antioksidan sistemi güçlendirerek Cu temelli oksidasyonun engellenmesini sağlayabilir.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Antioksidan · E vitamini · Melatonin

Özet

Bakır (Cu) bileşikleri özellikle endüstri ve tarımda geniş kullanım alanına sahiptir. İz miktardaki Cu hayatın sürdürülebilir olması için gerekliyken fazlası organizma için toksik etki yapmaktadır. Bu çalışma akut Cu toksisitesinde melatonin ve E vitamini’nin böbreklerdeki antioksidan enzim aktivitelerine etkisinin araştırılması amacıyla planlanmıştır. Çalışmada 28 Wistar albino sıçanlar kontrol grubu, Cu grubu, Cu+E vitamini grubu ve Cu+Melatonin grubu şeklinde eşit dört gruba (n=7) ayrıldı. Böbrek dokusunda süperoksit dismutaz (SOD), glutatyon peroksidaz (GPx), katalaz (KAT) enzim aktiviteleri ve protein karbonil içeriği analiz edildi. Ayrıca böbrek fonksiyon testleri değerlendirildi. Bakır uygulaması, kreatinin, kan üre nitrojeni (BUN), ürik asit, Na, K ve Mg değerlerini artırırken, E vitamini ve melatonin bu değerlerin azalmasında etkili oldu. Karbonil seviyesi, Cu+E vitamini veya Cu+melatonin gruplarında Cu grubuna göre önemli derecede azaldı. Doku SOD, GPx ve KAT aktiviteleri Cu maruziyeti sonucu düşmesine rağmen; E vitamini veya melatonin uygulaması, bu aktivitelerde önemli bir artışa neden oldu. Sonuç olarak, E vitamini ve melatonin takviyesi antioksidan sistemi güçlendirerek Cu temelli oksidasyonun engellenmesini sağlayabilir. Bu sayede nefrotoksisitenin gelişmesini önleyerek koruyucu bir fonksiyon gösterebilir.

Abstract

Copper (Cu) compounds have been widely used in various fields especially industrial processes and agriculture. Although trace amounts of Cu are essential to sustain life, excessive Cu is toxic for living organisms. This study aims to investigate the effects of vitamin E and melatonin on antioxidant enzymes activities in kidney against acute Cu toxicity. In this study, 28 Wistar albino rats were divided four equal groups (n=7) as control, Cu, Cu+Vitamin E, and Cu+Melatonin groups. Superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) enzymes activities and protein carbonyl content were analyzed. Also, kidney function tests were evaluated. While Cu administration increased creatinine, blood urea nitrogen (BUN), uric acid, Na, K and Mg levels, vitamin E and melatonin was effective reduction on these levels. Carbonyl level significantly decreased in Cu+Vitamin E and Cu+melatonin groups compared to Cu group. Although SOD, GPx and CAT activities in tissue decreased by Cu exposure, vitamin E and melatonin treatment showed significant increase on their activities. Consequently, vitamin E and melatonin supplements may provide prevention Cu -based oxidation by strengthening the antioxidant defense system. In this respect, it may show a protective effect by preventing the development of nephrotoxicity.

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Bu Makaleye Atıf Yap

Temiz, M. A., Temur, A. (2018). Bakır Nefrotoksisitesinde Melatonin ve E Vitamini’nin Antioksidan Parametreler Üzerine Etkileri. Veterinary Sciences and Practices, Cilt: 13 Sayı: 3, 347–354. https://doi.org/10.17094/ataunivbd.370501

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