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Dergiler / International Journal of Secondary Metabolite / 2021 / Cilt: 8 - Sayı: 2

Investigation of Phenolic Composition, Antioxidant Capacity, and Antidiabetic Effect of Ornithogalum lanceolatum L.: An in vitro Study

Mehmet Ali TEMİZ
Sayfa
94–103
Yayın Tarihi
2021-06-15
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

These findings reveal the importance of traditional remedies in the ethnopharmacological use of herbs.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Diabetes Mellitus is a global health problem that leads to macro- and microvascular diseases associated with hyperglycemia.
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Temel Bulgular & Veri:This study aims to investigate the phenolic composition using High-Performance Liquid Chromatography as well as antioxidant and antidiabetic effects using spectrophotometric method of Ornithogalum lanceolatum L. aerial parts and bulb.
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Sonuç & Katkı:These findings reveal the importance of traditional remedies in the ethnopharmacological use of herbs.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:ABTS · Antidiabetic · α-glucosidase

Özet

Diabetes Mellitus is a global health problem that leads to macro- and microvascular diseases associated with hyperglycemia. Phytotherapy is one of the alternative ways to cope with this type of disease. The genus Ornithogalum is consumed as a wild edible plant and traditionally used for ailments. This study aims to investigate the phenolic composition using High-Performance Liquid Chromatography as well as antioxidant and antidiabetic effects using spectrophotometric method of Ornithogalum lanceolatum L. aerial parts and bulb. In order to determine the antioxidant capacity total phenolic content, total flavonoid content and DPPH and ABTS free radical scavenging activities were analyzed in O. lanceolatum. Moreover, in vitro inhibitory effects of the O. lanceolatum aerial parts and bulb on digestive enzymes were determined by evaluating the α-amylase and α-glucosidase activities. Protocatechuic acid was found to be the main compound in both plant parts. However, the amounts of the total phenolic acids and flavonoids were found higher in the aerial parts than those in bulb as well. Furthermore, O. lanceolatum aerial parts exhibited more radical scavenging activity than bulb. The α-amylase and α-glucosidase IC50 inhibition activities of aerial parts were found more efficient than those for bulb. It can be concluded that O. lanceolatum can enhance the antioxidant status and also can prevent nutraceutically postprandial hyperglycemia by inhibiting α-amylase and α-glucosidase enzymes. These findings reveal the importance of traditional remedies in the ethnopharmacological use of herbs.

Abstract

Diabetes Mellitus is a global health problem that leads to macro- and microvascular diseases associated with hyperglycemia. Phytotherapy is one of the alternative ways to cope with this type of disease. The genus Ornithogalum is consumed as a wild edible plant and traditionally used for ailments. This study aims to investigate the phenolic composition using High-Performance Liquid Chromatography as well as antioxidant and antidiabetic effects using spectrophotometric method of Ornithogalum lanceolatum L. aerial parts and bulb. In order to determine the antioxidant capacity total phenolic content, total flavonoid content and DPPH and ABTS free radical scavenging activities were analyzed in O. lanceolatum. Moreover, in vitro inhibitory effects of the O. lanceolatum aerial parts and bulb on digestive enzymes were determined by evaluating the α-amylase and α-glucosidase activities. Protocatechuic acid was found to be the main compound in both plant parts. However, the amounts of the total phenolic acids and flavonoids were found higher in the aerial parts than those in bulb as well. Furthermore, O. lanceolatum aerial parts exhibited more radical scavenging activity than bulb. The α-amylase and α-glucosidase IC50 inhibition activities of aerial parts were found more efficient than those for bulb. It can be concluded that O. lanceolatum can enhance the antioxidant status and also can prevent nutraceutically postprandial hyperglycemia by inhibiting α-amylase and α-glucosidase enzymes. These findings reveal the importance of traditional remedies in the ethnopharmacological use of herbs.

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Bu Makaleye Atıf Yap

TEMİZ, M. A. (2021). Investigation of Phenolic Composition, Antioxidant Capacity, and Antidiabetic Effect of Ornithogalum lanceolatum L.: An in vitro Study. International Journal of Secondary Metabolite, Cilt: 8 - Sayı: 2, 94–103. https://ajindex.com/articles/672879

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Kaynakça (10)

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