Dergiler / Kafkas Journal of Medical Sciences / 2022 / Cilt: 12 - Sayı: 2

Association of Admission Troponin Levels with Hospitalization and Mortality in COVID-19 Patients

Sayfa
152–159
Yayın Tarihi
2022-08-31
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

However, neither cTnT values, nor thoracic CT score have a statistically significant effect on survival even if their distributions are different between survived and non-survived groups.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Aim: This study aims to identify the association of cardiac Troponin T (cTnT) levels with hospitalization and in-hospital-mortality in patients admitted to emergency department (ED) and diagnosed with COVID-19.
📊
Temel Bulgular & Veri:Material and Method: We scanned the data of adult patients presenting to the ED of a university hospital within 50 days of the first COVID-19 case admission (March 2020-May 2020) retrospectively.
💡
Sonuç & Katkı:However, neither cTnT values, nor thoracic CT score have a statistically significant effect on survival even if their distributions are different between survived and non-survived groups.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:2020 Verileri
⚙️Değişkenler:COVID-19 · computed tomography · emergency department

Abstract

Aim: This study aims to identify the association of cardiac Troponin T (cTnT) levels with hospitalization and in-hospital-mortality in patients admitted to emergency department (ED) and diagnosed with COVID-19. Material and Method: We scanned the data of adult patients presenting to the ED of a university hospital within 50 days of the first COVID-19 case admission (March 2020-May 2020) retrospectively. The study group consisted of patients diagnosed with COVID-19 by reverse-transcriptase polymerase-chain reaction, had cTnT test. Demographic and laboratory data, thoracic computed tomography (CT) imaging findings, length of hospital stay were also collected. The study outcomes were patients’ hospitalization status and in-hospital mortality. Results: Out of 36 patients, 9 (25%) were discharged, 20 (55.6%) remained in-patients in the ward, and 7 (19.4%) in intensive care unit. When overall in-patients were compared to discharged patients, a significant difference was observed with regard to age [median (25%-75%)] [60 (45-69) to 28 (26-39.5) years, respectively; p=0.003)], thoracic CT score [6 (0-11) to 0 (0-0.5), respectively; p=0.005], admission cTnT values [5.99 (3.50-15.55) to 3 (3-3.28) ng/L; p=0.012]. Mortality rate among in-patients was 18.5%. In the multivariate cox regression model none of these parameters had a significant effect on survival. Conclusion: The cTnT values of COVID-19 patients are likely to be associated with hospitalization, and mortality. Thoracic CT score was higher in patients who were admitted to intensive care unit. However, neither cTnT values, nor thoracic CT score have a statistically significant effect on survival even if their distributions are different between survived and non-survived groups.

🔖

Bu Makaleye Atıf Yap

OSKAY, A., ÇAKMAK, V., ŞENOL, H., OSKAY, T., ÖZEN, M., YILMAZ, A., SEYİT, M. (2022). Association of Admission Troponin Levels with Hospitalization and Mortality in COVID-19 Patients. Kafkas Journal of Medical Sciences, Cilt: 12 - Sayı: 2, 152–159. https://ajindex.com/articles/891929

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (12)

  1. Fan Y, Jiang M, Gong D, Man C, Chen Y. Cardiac troponin for predicting all-cause mortality in patients with acute ischemic stroke: a meta-analysis. Biosci Rep 2018;38(2):BSR20171178
  2. Ostermann M, Ayis S, Tuddenham E, Lo J, Lei K, Smith J, et al. Cardiac Troponin Release is Associated with Biomarkers of Inflammation and Ventricular Dilatation During Critical Illness. Shock 2017;47(6):702-8
  3. Kaura A, Panoulas V, Glampson B, Davies J, Mulla A, Woods K, et al. Association of Troponin Level and Age With Mortality in 250 000 Patients: Cohort Study Across Five UK Acute Care Centres. BMJ 2019;367:l6055
  4. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med 2020;382(18):1708-1720
  5. T.C. Sağlık Bakanlığı Halk Sağlığı Genel Müdürlüğü, COVID-19 (SARS-CoV-2 Enfeksiyonu) Genel Bilgiler, Epidemiyoloji ve Tanı. Bilimsel Danışma Kurulu Çalışması. (Republic of Turkey Ministry COVID-19 Information Page) Available at: https://covid19.saglik.gov.tr/Eklenti/39551/0/covid-19rehberigenelbilgilerepidemiyolojivetanipdf.pdf (Accessed: 11 January 2021
  6. T.C. Sağlık Bakanlığı Halk Sağlığı Genel Müdürlüğü, COVID-19 (SARS-CoV2 Enfeksiyonu) Rehberi (Bilim Kurulu Çalışması). (Republic of Turkey Ministry COVID-19 Information Page) Available at: https://covid19.saglik.gov.tr/ (Accessed: 11 January 2021
  7. Ai T, Yang Z, Hou H, Zhan C, Chen C, Lv W, et al. Correlation of Chest CT and RT-PCR Testing in Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases. Radiology 2020;296(2):E32-E40
  8. Bernheim A, Mei X, Huang M, Yang Y, Fayad ZA, Zhang N, et al. Chest CT Findings in Coronavirus Disease 2019 (COVID-19): Relationship to Duration of Infection. Radiology 2020;295:685–91
  9. Katneni UK, Alexaki A, Hunt RC, Schiller T, DiCuccio M, Buehler PW, et al. Coagulopathy and Thrombosis as a Result of Severe COVID-19 Infection: A Microvascular Focus. Thromb Haemost 2020;120(12):1668-79
  10. Bessière F, Khenifer S, Dubourg J, Durieu I, Lega JC. Prognostic value of troponins in sepsis: a meta-analysis. Intensive Care Med 2013;39(7):1181-9
  11. Pellegrini D, Kawakami R, Guagliumi G, Sakamoto A, Kawai K, Gianatti A, et al. Microthrombi As A Major Cause of Cardiac Injury in COVID-19: A Pathologic Study. Circulation 2021;143(10):1031-42
  12. Republic of Turkey, Ministry of Health. COVID-19 Situation Report Turkey. Available at: https://rm.coe.int/1-turkey-ministry-health-covid-19-report-july-2020/16809ef5