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Dergiler / The European Research Journal / 2023 / Cilt: 9 - Sayı: 3

Evaluation of the uric acid and hematological parameters in patients with nodal hand osteoarthritis

Ayşe ÜNAL ENGİNAR
Sayfa
561–566
Yayın Tarihi
2023-05-04
DOI
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Clarification of the relationship between inflammation, uric acid, and hand OA, which is a heterogeneous disease, will be useful in the follow-up and treatment of patients.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objectives: To compare patients with symptomatic nodal hand osteoarthritis (OA) with a control group in respect of inflammation parameters, uric acid, and hematological parameters.
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Temel Bulgular & Veri:Methods: The study included 50 post-menopausal female patients, aged 40-80 years, diagnosed with symptomatic nodal hand OA, and a control group of 50 post-menopausal females in the same age range with no hand OA.
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Sonuç & Katkı:Clarification of the relationship between inflammation, uric acid, and hand OA, which is a heterogeneous disease, will be useful in the follow-up and treatment of patients.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Hand osteoarthritis · monocyte-lymphocyte ratio · neutrophil–lymphocyte ratio

Abstract

Objectives: To compare patients with symptomatic nodal hand osteoarthritis (OA) with a control group in respect of inflammation parameters, uric acid, and hematological parameters. Methods: The study included 50 post-menopausal female patients, aged 40-80 years, diagnosed with symptomatic nodal hand OA, and a control group of 50 post-menopausal females in the same age range with no hand OA. Patient data including age, monocyte, neutrophil, lymphocyte, and thrombocyte counts, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, uric acid level, and the Kellgren-Lawrence (KL) score obtained from evaluations of hand radiographs, were recorded retrospectively from the hospital information system. The neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and monocyte-lymphocyte ratio (MLR) were calculated. The data were compared between the two groups. Results: The data of 100 females were compared, comprising a patient group of 50 patients with symptomatic nodal OA, and a control group of 50 females. Age, monocyte, neutrophil, lymphocyte, and thrombocyte counts, NLR, PLR, MLR, ESR, CRP, and uric acid level were compared. With the exception of MLR and ESR, no statistically significant difference was determined between the two groups. The MLR was determined to be statistically significantly higher in the control group than in the patient group (p = 0.024). The ESR was determined to be statistically significantly higher in the patient group than in the control group p < 0.001). When patients with a KL score of 2 and 3 were compared, with the exception of age, no other difference was determined. Patients with a KL score of 3 were seen to be significantly older (p = 0.032). Conclusions: ESR was determined to be significantly higher in patients with symptomatic nodal OA. Clarification of the relationship between inflammation, uric acid, and hand OA, which is a heterogeneous disease, will be useful in the follow-up and treatment of patients.

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Bu Makaleye Atıf Yap

ENGİNAR, A. Ü. (2023). Evaluation of the uric acid and hematological parameters in patients with nodal hand osteoarthritis. The European Research Journal, Cilt: 9 - Sayı: 3, 561–566. https://ajindex.com/articles/888762

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Kaynakça (15)

  1. Hunter DJ, Bierma-Zeinstra S. Osteoarthritis. Lancet 2019;393:1745-59
  2. Marshal M, Watt FE, Vincent TL, Dziedzic K. Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management. Nat Rev Rheumatol 2018;14:641-56
  3. Zhang Y, Niu J, Kelly-Hayes M, Chaisson CE, Aliabadi P, Felson DT. Prevalence of symptomatic hand osteoarthritis and its impact on functional status among the elderly: the Framingham study. Am J Epidemiol 2002;156:1021-7
  4. Kloppenburg M, Kwok W-Y. Hand osteoarthritis -a- heterogeneous disorder. Nat Rev Rheumatol 2012;8:22-31
  5. Plotz B, Bomfim F, Sohail MA, Samuels J. Current epidemiology and risk factors for the development of hand osteoarthritis. Curr Rheumatol Rep 2021;23:61
  6. Robinson WH, Lepus CM, Wang Q, Raghu H, Mao R, Lindstrom TM, et al. Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis. Nat Rev Rheumatol 2016;12:580-92
  7. Berenbaum F. Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). Osteoarthritis Cartilage 2013;21:16-21
  8. Favero M, Belluzzi E, Ortolan A, Lorenzin M, Oliviero F, Doria A, et al. Erosive hand osteoarthritis:Latest findings and outlook. Nat Rev Rheumatol 2022;18:171-83
  9. Ding X, Zeng C, Wei J, Li H, Yang T, Zhang Y, et al. The associations of serum uric acid level and hyperuricemia with knee osteoarthritis. Rheumatol Int 2016;36:567-73
  10. Xiao L, Lin S, Zhan F. The association between serum uric acid level and changes of MRI findings in knee osteoarthritis: a retrospective study (A STROBE-compliant article). Medicine (Baltimore) 2019;98:e1581
  11. Gao K, Zhu W, Liu W, Ma D, Li H, Yu W, et al. Diagnostic value of the blood monocyte–lymphocyte ratio in knee osteoarthritis. J Int Med Res 2019;47:4413-21
  12. Shi J, Zhao W, Ying H, Du J, Chen J, Chen S, et al. The relationship of platelet to lymphocyte ratio and neutrophil to monocyte ratio to radiographic grades of knee osteoarthritis. Z Rheumatol 2017;77:533-7
  13. Ionitescu M, Vermeşan D, Haraguş H, Sucui O, Todor A, Dumitraşcu CV, et al. Association of neutrophil to lymphocyte ratio with patient reported outcomes in knee osteoarthritis. Appl Sci 2020;10:8173
  14. Altman R, Alarcon G, Appelrouth D, Bloch D, Borenstein D, Brandt K, et al. The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hand. Arthritis Rheum 1990;33:1601-10
  15. Jin X, Beguerie JR, Zhang W, Blizzard L, Otahal P, Jones G, et al. Circulating C reac