Reshaping cytoskeleton: different acts of modulatory compounds

Temel Bulgular & Veri:The cytoskeleton is an essential component of cells due to its role in various cellular functions, such as intracellular transport, organelle positioning, chromosome segregation and cytokinesis.

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Sonuç & Katkı:In this review, we focused on cytoskeleton modulatory compounds and summarized their mechanisms of action.

🔬Tür:Literatür & Derleme Çalışması

📍Kapsam:Genişletilmiş Akademik Örneklem

⚙️Değişkenler:Microtubule · actin · cytoskeleton modulatory compounds

Abstract

The eukaryotic cytoskeleton is composed of filamentous structures, namely microfilaments, microtubules and intermediate filaments. The cytoskeleton is an essential component of cells due to its role in various cellular functions, such as intracellular transport, organelle positioning, chromosome segregation and cytokinesis. Abnormalities in cytoskeleton, as well as associated proteins and regulatory pathways, have been shown to contribute to disease pathomechanisms including cancer and neurodegenerative diseases. Therefore, cytoskeleton is an important therapeutic target and many compounds have been identified or developed to modulate the cytoskeleton. In this review, we focused on cytoskeleton modulatory compounds and summarized their mechanisms of action.

Anahtar kelimeler

Microtubule actin cytoskeleton modulatory compounds

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Bu Makaleye Atıf Yap

ZOBAROĞLU, P., BORA, G. (2020). Reshaping cytoskeleton: different acts of modulatory compounds. İstanbul Journal of Pharmacy, Cilt: 50 - Sayı: 3, 304–311. https://ajindex.com/articles/88765

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