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Dergiler / Journal of the Turkish Chemical Society Section A: Chemistry / 2016 / Cilt: 3 - Sayı: 3

THE SYNTHESES AND STRUCTURAL CHARACTERIZATIONS, ANTIMICROBIAL ACTIVITY AND IN VITRO DNA BINDING OF 4-FLUOROBENZYLSPIRO(N/O)CYCLOTRIPHOSPHAZENES AND THEIR PHOSPHAZENIUM SALTS

Gamze Elmas
Aytuğ Okumuş
Zeynel Kılıç
L. Yasemin Gönder
Leyla Açık
Tuncer Hökelek
Sayfa
25–46
Yayın Tarihi
2017-01-08
DOI
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The interactions of the compounds with supercoiled pUC18 plasmid DNA were investigated.

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Amaç & Hipotez:In the present study, the condensation reaction of N3P3Cl6 (1) with sodium 3-(4-fluorobenzylamino)-1-propanoxide gave partly substituted 4-fluorobenzylspiro cyclotriphosphazene (2).
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Temel Bulgular & Veri:The Cl replacement reactions of 2 with excess benzylamine, n-hexylamine, n-buthylamine and n-propylamine led to the formation of the corresponding 4-fluorobenzylspiro(N/O)tetrabenzylamino (3a), tetrahexylamino (3b), tetrabuthylamino (3c) and tetrapropylamino (3d) cyclotriphosphazenes.
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Sonuç & Katkı:The interactions of the compounds with supercoiled pUC18 plasmid DNA were investigated.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

In the present study, the condensation reaction of N3P3Cl6 (1) with sodium 3-(4-fluorobenzylamino)-1-propanoxide gave partly substituted 4-fluorobenzylspiro cyclotriphosphazene (2). The Cl replacement reactions of 2 with excess benzylamine, n-hexylamine, n-buthylamine and n-propylamine led to the formation of the corresponding 4-fluorobenzylspiro(N/O)tetrabenzylamino (3a), tetrahexylamino (3b), tetrabuthylamino (3c) and tetrapropylamino (3d) cyclotriphosphazenes. The protic ionic liquids (PILs), phosphazenium salts (4a-4d), were obtained from the reactions of the corresponding phosphazene bases (3a-3d) with gentisic acid in dry THF. The structures of all the isolated cyclotriphosphazene derivatives were determined by elemental analyses, FTIR and 1H, 13C{1H}, 31P{1H} NMR techniques. The crystal structure of 4d was verified by X-ray diffraction analysis. All the compounds were screened for antibacterial and antifungal activities against bacteria and yeast strains. The interactions of the compounds with supercoiled pUC18 plasmid DNA were investigated.

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Bu Makaleye Atıf Yap

Elmas, G., Okumuş, A., Kılıç, Z., Gönder, L. Y., Açık, L., Hökelek, T. (2017). THE SYNTHESES AND STRUCTURAL CHARACTERIZATIONS, ANTIMICROBIAL ACTIVITY AND IN VITRO DNA BINDING OF 4-FLUOROBENZYLSPIRO(N/O)CYCLOTRIPHOSPHAZENES AND THEIR PHOSPHAZENIUM SALTS. Journal of the Turkish Chemical Society Section A: Chemistry, Cilt: 3 - Sayı: 3, 25–46. https://ajindex.com/articles/781622

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Kaynakça (2)

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