Phytochemical Profiling and Evaluation of Marrubium sivasense Aytaç, Akgül & Ekici for Antioxidant Activity and Inhibition Effects on α-Amylase, Lipoxygenase, Xanthine Oxidase and Tyrosinase Enzymes
The extract demonstrated hypoglycemic activity (Inh. 49.67±1.09 %.) via inhibition of porcine pancreatic α-amylase, the antiinflammatory effect of the extract tested via inhibition of 5-LOX was found as Inh 18.71±0.74 %, however no antityrosinase activity was found.
📌 3 Maddede Bu Makale
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Amaç & Hipotez:Methanol extract of Marrubium. sivasense Aytaç, Akgül & Ekici was analyzed with LC-MS/MS technique.
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Temel Bulgular & Veri:Antioxidant properties of the extract was determined by DPPH free radical scavenging activity (IC50 0.34 mg/mL), trolox equivalent antioxidant capacity (TEAC) (2.3 mM±0.04), xanthine-xanthine oxidase(XO) inhibitory effect (16.54 %). and.
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Sonuç & Katkı:The extract demonstrated hypoglycemic activity (Inh. 49.67±1.09 %.) via inhibition of porcine pancreatic α-amylase, the antiinflammatory effect of the extract tested via inhibition of 5-LOX was found as Inh 18.71±0.74 %, however no antityrosinase activity was found.
Methanol extract of Marrubium. sivasense Aytaç, Akgül & Ekici was analyzed with LC-MS/MS technique. Forsythoside B, verbascoside and leucoseptoside were identified as main compounds. Antioxidant properties of the extract was determined by DPPH free radical scavenging activity (IC50 0.34 mg/mL), trolox equivalent antioxidant capacity (TEAC) (2.3 mM±0.04), xanthine-xanthine oxidase(XO) inhibitory effect (16.54 %). and. B-carotene bleaching (Inh. 43±1.26 %) assays. The extract demonstrated hypoglycemic activity (Inh. 49.67±1.09 %.) via inhibition of porcine pancreatic α-amylase, the antiinflammatory effect of the extract tested via inhibition of 5-LOX was found as Inh 18.71±0.74 %, however no antityrosinase activity was found.
GÖĞER, F., ÖZEK, G., TEKİN, M., YUR, S., ÖZEK, T. (2019). Phytochemical Profiling and Evaluation of Marrubium sivasense Aytaç, Akgül & Ekici for Antioxidant Activity and Inhibition Effects on α-Amylase, Lipoxygenase, Xanthine Oxidase and Tyrosinase Enzymes. Journal of the Turkish Chemical Society Section A: Chemistry, Cilt: 6 - Sayı: 3, 281–292. https://ajindex.com/articles/781264
Aytaç Z, Akgul G, Ekici M. A New Species of Marrubium (Lamiaceae) from Central Anatolia, Turkey. Turk J Bot. 2012;36:443-9
Akgül G, Ketenoglu O. The new subspecies for the Flora of Turkey: Marrubium cephalanthum Boiss. & Noë subsp. akdağhicum (Lamiaceae). In: Ürgüp, Turkey: IXth National Conference on Ecology; 7-10 October;, Nevşehir: Nevşehir University Faculty of Science; 2009
Tuylu M, Büyükkartal HN, Akgül G, Kalyoncu H. Marrubium lutescens Boiss. ve M. cephalanthum Boiss. & Noë subsp. akdaghicum (Lamiaceae)'un gövde ve yaprak özelliklerinin anatomik olarak karşılaştırılması. Süleyman Demirel Univ. J Nat Appl Sci. 2017;21(1):113‐7
Firat M. Marrubium eriocephalum (Lamiaceae); a Species New to the Flora of Turkey, with Contributions to its Taxonomy. PhytoKeys. 2016(58):9-20
Davis PH, Mill RR, Kit T. Flora of Turkey and the East Aegean Islands (Suppl. 1). Edinburgh: Edinburgh University Press; 1988. p. 202-3
Meyre-Silva C, Cechinel-Filho V. A Review Of The Chemical And Pharmacological Aspects of the Genus Marrubium. Curr Pharm Des. 2010;16(31):3503-18
Karioti A, Protopappa A, Megoulas N, Skaltsa H. Identification of Tyrosinase Inhibitors from Marrubium velutinum and Marrubium cylleneum. Bioorg Med Chem. 2007;15(7):2708-14
Golmakani H, Rabbani Nasab H, Sharifan M, Kamali H, Yadollahi A. The Essential Oil Composition and Antibacterial Activity of Marrubium duabense Murata from North Khorassan Province, Iran. J Essent Oil Bear Plants. 2016;19(4):963-71
Masoodi M, Ali Z, Liang S, Yin H, Wang W, Khan IA. Labdane Diterpenoids from Marrubium vulgare. Phytochem Lett. 2015;13:275-9
Piozzi F, Bruno M, Rosselli S, Maggio A. The Diterpenoids of The Genus Marrubium (Lamiaceae). Nat Prod Commun. 2006;7:585-92
Dehbashi Z, Mazaheri M, Saeedi S, Sabbagh SK. Antibacterial Activity of Marrubium vulgare L. Against Antibiotic Resistance Klebsiella pneumoniae Strains. Adv Herb Med. 2015;1(3):9-14
Hamedeyazdan S, Sharifi S, Nazemiyeh H, Fathiazad F. Evaluating Antiproliferative And Antioxidant Activity of Marrubium crassidens. Adv Pharm Bull. 2014;4(Supp1):459-64
De Jesus R, Cechinel-Filho V, Oliveira A, Schlemper V. Analysis of the Antinociceptive Properties of Marrubiin Isolated From Marrubium vulgare. Phytomed. 2000;7(2):111-5
Boudjelal A, Henchiri C, Siracusa L, Sari M, Ruberto G. Compositional Analysis And In Vivo Anti-Diabetic Activity Of Wild Algerian Marrubium vulgare L. Infusion. Fitoterapia. 2012;83(2):286-92.