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Dergiler / Journal of Surgery and Medicine / 2021 / Cilt: 5 - Sayı: 3

The effect of edaravone on a rat fracture model complicated with ischemia

Sezer ASTAN
Murat AŞÇI
Orhan BALTA
Erkal BİLGİÇ
Mehmet Burtaç EREN
Sayfa
255–259
Yayın Tarihi
2021-03-01
DOI
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Results: There were no differences between the groups in terms of biomechanical and radiological indices, except for hardness values in the control subjects (Group 5), which were significantly higher than those of the other groups (P

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Background/Aim: Ischemia is a common issue in fracture healing due to vascular injury, compartment syndrome, and long-term tourniquet use.
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Temel Bulgular & Veri:Methods: We conducted our study on forty-four rats divided into four study groups and a control group, as follows: Group 1- Fracture, Group 2- Fracture-ischemia, Group 3- Fracture-ischemia-edaravone, Group 4- Fracture-edaravone, and Group 5- Control group.
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Sonuç & Katkı:Results: There were no differences between the groups in terms of biomechanical and radiological indices, except for hardness values in the control subjects (Group 5), which were significantly higher than those of the other groups (P
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:fracture healing · edaravone · ischemia-reperfusion injury

Abstract

Background/Aim: Ischemia is a common issue in fracture healing due to vascular injury, compartment syndrome, and long-term tourniquet use. With ischemia-reperfusion injury, normal tissue repair can become complicated. In our study, we aimed to investigate the effect of edaravone on fracture union in a rat fracture model complicated with ischemia. Methods: We conducted our study on forty-four rats divided into four study groups and a control group, as follows: Group 1- Fracture, Group 2- Fracture-ischemia, Group 3- Fracture-ischemia-edaravone, Group 4- Fracture-edaravone, and Group 5- Control group. The control group comprised the contralateral intact tibia of the rats in Group 1 that were not complicated with ischemia and were not given edaravone treatment. The effects of edaravone on fracture healing were evaluated histologically, radiologically, and biomechanically. Results: There were no differences between the groups in terms of biomechanical and radiological indices, except for hardness values in the control subjects (Group 5), which were significantly higher than those of the other groups (P

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Bu Makaleye Atıf Yap

ASTAN, S., AŞÇI, M., BALTA, O., BİLGİÇ, E., EREN, M. B. (2021). The effect of edaravone on a rat fracture model complicated with ischemia. Journal of Surgery and Medicine, Cilt: 5 - Sayı: 3, 255–259. https://ajindex.com/articles/780024

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