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Journals / Journal of Surgery and Medicine / 2021 / Cilt: 5 - Sayı: 3

The effect of edaravone on a rat fracture model complicated with ischemia

Sezer ASTAN
Murat AŞÇI
Orhan BALTA
Erkal BİLGİÇ
Mehmet Burtaç EREN
Pages
255–259
Publication Date
2021-03-01
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Results: There were no differences between the groups in terms of biomechanical and radiological indices, except for hardness values in the control subjects (Group 5), which were significantly higher than those of the other groups (P

📌 3 Key Takeaways

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Objective & Hypothesis:Background/Aim: Ischemia is a common issue in fracture healing due to vascular injury, compartment syndrome, and long-term tourniquet use.
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Key Findings & Data:Methods: We conducted our study on forty-four rats divided into four study groups and a control group, as follows: Group 1- Fracture, Group 2- Fracture-ischemia, Group 3- Fracture-ischemia-edaravone, Group 4- Fracture-edaravone, and Group 5- Control group.
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Conclusion & Impact:Results: There were no differences between the groups in terms of biomechanical and radiological indices, except for hardness values in the control subjects (Group 5), which were significantly higher than those of the other groups (P
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:fracture healing · edaravone · ischemia-reperfusion injury

Abstract

Background/Aim: Ischemia is a common issue in fracture healing due to vascular injury, compartment syndrome, and long-term tourniquet use. With ischemia-reperfusion injury, normal tissue repair can become complicated. In our study, we aimed to investigate the effect of edaravone on fracture union in a rat fracture model complicated with ischemia. Methods: We conducted our study on forty-four rats divided into four study groups and a control group, as follows: Group 1- Fracture, Group 2- Fracture-ischemia, Group 3- Fracture-ischemia-edaravone, Group 4- Fracture-edaravone, and Group 5- Control group. The control group comprised the contralateral intact tibia of the rats in Group 1 that were not complicated with ischemia and were not given edaravone treatment. The effects of edaravone on fracture healing were evaluated histologically, radiologically, and biomechanically. Results: There were no differences between the groups in terms of biomechanical and radiological indices, except for hardness values in the control subjects (Group 5), which were significantly higher than those of the other groups (P

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Cite This Article

ASTAN, S., AŞÇI, M., BALTA, O., BİLGİÇ, E., EREN, M. B. (2021). The effect of edaravone on a rat fracture model complicated with ischemia. Journal of Surgery and Medicine, Cilt: 5 - Sayı: 3, 255–259. https://ajindex.com/articles/780024

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References (13)

  1. Yamamoto T, Yuki S, Watanabe T, Mitsuka M, Saito KI, Kogure K. Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia. Brain Res. 1997
  2. doi: 10.1016/s0006-8993(97)00490-3 PMID: 9262182 2. Garrett IR, Boyce BF, Oreffo R, Bonewald L, Poser J, Mundy GR. Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. J Clin Invest. 1990
  3. doi: 10.1172/JCI114485. 3. Skjeldal S, Grøgaard B, Reikerås O, Müller C, Torvik A, Svindland A. Model for skeletal muscle ischemia in rat hindlimb: Evaluation of reperfusion and necrosis. Eur Surg Res. 1991
  4. doi: 10.1159/000129176. 4. Lane JM, Sandhu H. Current approaches to experimental bone grafting. Orthop Clin North Am 1987
  5. Huddleston PM, Steckelberg JM, Hanssen AD, Rouse MS, Bolander ME, Patel R. Ciprofloxacin inhibition of experimental fracture-healing. J Bone Joint Surg Am. 2000
  6. 73 doi: 10.2106/00004623-200002000-00002. 6. Lu C, Miclau T, Hu D, Marcucio RS. Ischemia leads to delayed union during fracture healing: A mouse model. J Orthop Res. 2007
  7. doi: 10.1002/jor.20264 7. Cetinus E, Kilinç M, Uzel M, Inanç F, Kurutaş EB, Bilgic E, et al. Does long-term ischemia affect the oxidant status during fracture healing? Arch Orthop Trauma Surg. 2005
  8. doi: 10.1007/s00402-005-0825-3. 8. Lu C, Saless N, Wang X, Sinha A, Decker S, Kazakia G, et al. The role of oxygen during fracture healing. Bone. 2013
  9. doi: 10.1016/j.bone.2012.09.037 9. Wang WZ, Fang XH, Stephenson LL, Baynosa RC, Khiabani KT, Zamboni WA. Microcirculatory effects of melatonin in rat skeletal muscle after prolonged ischemia. J Pin Res. 2005
  10. doi: 10.1111/j.1600-079X.2005.00215.x. 10. Sheweita S, Khoshhal K. Calcium metabolism and oxidative stress in bone fractures: Role of antioxidants. Curr Drug Metab. 2007
  11. doi: 10.2174/138920007780866852. 11. Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature. 2000
  12. doi: 10.1038/35041687. 12. Adams HP, Zoppo G, Alberts MJ, et al. Guidelines for the early management of adults with ischemic stroke: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Stroke 2007
  13. doi: 10.1161/STROKEAHA.107.181486. 13. Okatani Y, Wakatsuki A, Kaneda C. Melatonin increases activities of glutathione peroxidase and superoxide dismu