KaydedilenlerDerginizi ekleyin

Dergiler / Journal of Health Sciences and Medicine / 2022 / Cilt: 5 - Sayı: 4

Effect of chitosan application on lung tissue in rats with experimental fluorine toxicity

Bahattin BULDUK
Sayfa
969–972
Yayın Tarihi
2022-07-20
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: It has been predicted that chitosan application may be beneficial in preventing cellular damage that may occur with fluorine exposure.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Aim: The aim of this study is to investigate the effects of chitosan application on lung tissue in rats with experimental fluorine toxicity.
📊
Temel Bulgular & Veri:Material and Method: In the study, 21 healthy male wistar albino rats were used.
💡
Sonuç & Katkı:Conclusion: It has been predicted that chitosan application may be beneficial in preventing cellular damage that may occur with fluorine exposure.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Chitosan · Sodium fluoride · Antioxidant

Abstract

Aim: The aim of this study is to investigate the effects of chitosan application on lung tissue in rats with experimental fluorine toxicity. Material and Method: In the study, 21 healthy male wistar albino rats were used. Prior to the trial, the acclimation of the rats was provided. 3 groups were randomly generated in a way that there were 7 rats in each group. These were determined as the control group (C), the fluorosis group (NaF) and the fluorosis + chitosan (NaF+CS) group. Results: In the NaF group, CAT, SOD and GSH values were found to be low compared to other groups and MDA values were found to be high. It was found that the chitosan application reduced the CAT, SOD and GSH values, and increased the MDA value. Conclusion: It has been predicted that chitosan application may be beneficial in preventing cellular damage that may occur with fluorine exposure.

🔖

Bu Makaleye Atıf Yap

BULDUK, B. (2022). Effect of chitosan application on lung tissue in rats with experimental fluorine toxicity. Journal of Health Sciences and Medicine, Cilt: 5 - Sayı: 4, 969–972. https://ajindex.com/articles/776492

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (10)

  1. Altındağ F, Özdek U. Protective effects of chitosan and chitosan oligosaccharide on sodium fluoride-induced testicular damage in male rats: a stereological and histopathological study. Kafkas Üniversitesi Veteriner Fakültesi Derg 2021; 27: 183-9. Comba B. Hayvanlarda florozis, teşhis, tedavi ve koruma. Yüzüncü Yıl Üniversitesi Veteriner Fakültesi Derg 2013; 24: 41- Bulduk B, Uyar H, Oto G, et al. Effect Of exposure to fluorine and 7, 12-dimethyl benzanthracene on vascular responses. Fresenius Environmental Bulletin 2022; 31: 2826-31.
  2. Varol E, Varol S. Çevresel bir hastalık olarak florozis ve insan sağlığı üzerine etkisi. SDÜ Fen Bilimleri Enstitüsü, TAF Preventive Medicine Bulletin 2010; 9: 233-8.
  3. Wei W, Pang S, Sun D. The pathogenesis of endemic fluorosis: Research progress in the last 5 years. IJMCM 2019; 23: 2333-42. Purohit SD, gupta rc, mathur ak, gupta n, jeswani id, choudhary vk. experimental Pulmonary Fluorosis. Indian J Chest Dis Allied Sci 1999; 41: 27–34. Duman SS ve Şenel S. Kitosan ve veteriner alandaki uygulamaları. Veteriner Cerrahi Derg 2004; 10: 62-72.
  4. Ozdek U, Değer Y. Effects of chitosan and chitosan oligosaccharide on serum and tissue sialic acid levels in experimental fluorosis. J Institute Sci Technol 2021; 11: 1402-7.
  5. Placer ZA, Cushman LL, Johnson BC. Estimation of product of lipid peroxidation (malonyldialdehyde) in biochemical systems. Anal Biochem 1966; 16: 359-64. Aebi H. Catalase in vitro assay methods. Methods Enzymol 1984; 105: 121-6. Sedlak J and Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Analytic Biochem 1968; 25: 192-205.
  6. McCord JM, Fridovich I. Superoxide dismutase, an enzymatic function for erythrocuprein (hemocuprein). J Biol Chem 1969; 244: 6049-53.
  7. Bulduk M, Oto G, Ozdemir H, Demirel-Yilmaz E. The effect of resveratrol therapy on the vascular responses caused by chronıc fluorosis. Fluorid 2020; 53: 23-39.
  8. Chauhan SS, Ojha S, Mahmood A. Modulation of lipid peroxidation and antioxidant defense systems in rat intestine by subchronic fluoride and ethanol administration. Alcohol 2011; 45: 663-72.
  9. Aydın G, Çiçek E, Akdoğan M, Gökalp O. Histopathological and biochemical changes in lung tissues of rats following administration of fluoride over several generations. J Appl Toxicol 2003; 23: 437-46.
  10. Nabavı SF, Moghaddam AH, Eslamı S, Nabavı SY. Protective effects of curcumin against NaF induced toxicity in rat kidneys. Biol Trace Elem Res 2013; 145: 369–74.